排序方式: 共有85条查询结果,搜索用时 15 毫秒
1.
Federico Karp Florencia S. Satler Carlos A. Busatto Julio A. Luna Diana A. Estenoz Ludmila N. Turino 《应用聚合物科学杂志》2021,138(17):50293
The aim of the present work is the characterization of PLGA microparticles including biopolymers for the controlled release of tilmicosin, a broad-spectrum antibiotic. Microparticles were prepared using the double-emulsion solvent evaporation technique. The effect of alginate and pectin incorporation over particle size and porosity, encapsulation efficiency (EE) and pH-responsive drug release was evaluated. Formulations presented a mean particle size of 5.5 μm approximately and a drug EE ranged from 22%–57%. PLGA-Alginate particles showed an increased porosity. Tilmicosin release profiles from PLGA and PLGA-biopolymer microparticles were affected by the particular combination of polymers and the pH of the release medium. The experimental data was simulated using a mathematical model, which takes into account the autocatalytic polymer degradation and the different mechanisms of drug transport. The combination of PLGA and biopolymers strongly influenced the morphology of the particles, offering the possibility of controlling the drug release profiles according to the therapy. 相似文献
2.
Highly Efficient Perovskite Nanocrystal Light‐Emitting Diodes Enabled by a Universal Crosslinking Method
下载免费PDF全文
![点击此处可从《Advanced materials (Deerfield Beach, Fla.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
3.
Sklate Boja María Florencia Druker Ana Velia 《Metallurgical and Materials Transactions A》2022,53(11):3986-4003
Metallurgical and Materials Transactions A - We developed an Fe–22Mn–0.6C–1.5Al TWIP steel and investigated how thermo-mechanical processes affect the mechanical properties. In... 相似文献
4.
Benchmarking laboratory‐scale pomegranate vinegar against commercial wine vinegars: antioxidant activity and chemical composition
下载免费PDF全文
![点击此处可从《Journal of the science of food and agriculture》网站下载免费的PDF全文](/ch/ext_images/free.gif)
5.
Chemical Composition and Physical Properties of High Oleic Safflower Oils (Carthamus tinctorius,Var. CW88-OL and CW99-OL)
下载免费PDF全文
![点击此处可从《Journal of the American Oil Chemists](/ch/ext_images/free.gif)
Florencia Salaberría Diana Constenla Amalia A. Carelli María E. Carrín 《Journal of the American Oil Chemists' Society》2016,93(10):1383-1391
Chemical composition and physical properties of CW88‐OL and CW99‐OL cultivars of high oleic safflower seeds and their hexane‐extracted oils were determined. Dry‐based seed composition of CW88‐OL and CW99‐OL was: moisture = 4.29 and 4.23 %, oil = 42.29 and 46.44 %, Crude protein = 20.94 and 16.41 %, neutral detergent fiber = 28.11 and 28.49 %, ash = 1.55 and 2.01 %, phosphorus content = 2033 and 3995 mg/kg, respectively. Major fatty acids in oils were ~78 % oleic (O), ~13 % linoleic (L), ~5 % palmitic (P) and ~2 % stearic (St) acids, for both cultivars. The main triacylglycerols were OOO (~50 %), OOL (~20 %), SOL + OPO (~10 %), and LLP (~5 %). The oil composition of CW88‐OL and CW99‐OL in main minor components was: α‐tocopherol = 582 and 551 mg/kg, total sterols = 3996 and 3362 mg/kg, phospholipids = 22 and 21 mg/kg and wax content = 70 and 74 mg/kg. For both cultivars, density and viscosity of the oils between 25 and 55 °C varied from 903.4 to 912.6 kg/m3 and 63 to 23 mPa.s showing linear and exponential behaviors, respectively. The refractive index was 1.4694. The CIELab color parameters were: 89.69 and 89.53 (L*), ?3.72 and ?3.07 (a*), and 47.28 and 47.78 (b*) (CW88‐OL and CW99‐OL, respectively). Thus, the high oil content of the seeds and nutritional quality of the oil accompanied by low levels of waxes and phospholipids makes the cultivars studied promising for producers and consumers. 相似文献
6.
Andrea Snchez-Navarro Miguel ngel Martínez-Rojas Adrin Albarrn-Godinez Rosalba Prez-Villalva Johan Auwerx Abigail de la Cruz Lilia G. Noriega Florencia Rosetti Norma A. Bobadilla 《International journal of molecular sciences》2022,23(5)
Acute kidney injury (AKI) is a public health problem worldwide. Sirtuins are a family of seven NAD+-dependent deacylases, Overexpression of Sirtuin 1, 3, and 5 protect against AKI. However, the role of Sirtuin 7 (Sirt7) in AKI is not known. Here, we analyzed how Sirt7 deficient mice (KO-Sirt7) were affected by AKI. As expected, wild-type and Sirt7 heterozygotes mice that underwent renal ischemia/reperfusion (IR) exhibited the characteristic hallmarks of AKI: renal dysfunction, tubular damage, albuminuria, increased oxidative stress, and renal inflammation. In contrast, the KO-Sirt7+IR mice were protected from AKI, exhibiting lesser albuminuria and reduction in urinary biomarkers of tubular damage, despite similar renal dysfunction. The renoprotection in the Sirt7-KO+IR group was associated with reduced kidney weight, minor expression of inflammatory cytokines and less renal infiltration of inflammatory cells. This anti-inflammatory effect was related to diminished p65 expression and in its active phosphorylation, as well as by a reduction in p65 nuclear translocation. Sirt7 deficient mice are protected from AKI, suggesting that this histone deacetylase promotes tubular damage and renal inflammation. Therefore, our findings indicate that Sirt7 inhibitors may be an attractive therapeutic target to reduce NFκB signaling. 相似文献
7.
Andrés Aguirre Matías Cabruja Rodolfo Cabrera Florencia Eberhardt Salvador Peirú Hugo G. Menzella Rodolfo M. Rasia 《Journal of the American Oil Chemists' Society》2015,92(1):47-53
Steryl glucosides (SG) are common contaminants in biodiesel that form precipitates, which form and cause problems due to fouling during transport and storage. Therefore, their quantification is necessary to assess the quality of this fuel. The methods currently available for SG analysis require expensive instrumentation, need a previous concentration step by solid‐phase extraction (SPE) or are of limited use for the quantitative assessment. We developed an enzymatic method for SG quantification in biodiesel samples based on the hydrolysis of the glucoside catalyzed by a broadly specific beta glucosidase and the subsequent determination of the glucose released by the reaction. The method is non‐expensive, sensitive and was adapted to 96‐well format fluorescence plate reader, making it useful for the parallel assay of multiple samples. The enzymatic assay presented here represent a valuable tool for both quality control and the development of improved biodiesel production and purification procedures. 相似文献
8.
Development of Active Films From Pectin and Fruit Extracts: Light Protection,Antioxidant Capacity,and Compounds Stability
下载免费PDF全文
![点击此处可从《Journal of food science》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Kaliana S. Eça Mariana T. C. Machado Miriam D. Hubinger Florencia C. Menegalli 《Journal of food science》2015,80(11):C2389-C2396
Pectin films containing fruit extracts were developed and tested in relation to ultraviolet light transmission, phytochemical contents, and antioxidant capacity during 90 d shelf life storage. Aqueous and alcoholic extracts from 5 different fruits (acerola, cashew apple, papaya, pequi, and strawberry) were obtained. Because the alcoholic extracts from acerola, cashew apple, and strawberry presented the highest phytochemical content and antioxidant capacity, they were incorporated into pectin films individually or as a mixture. Incorporation of these extracts into pectin films provided antioxidant capacity while retaining the physical properties. The pectin films containing fruit extract acted as adequate light barrier and prevented photooxidation. Among the prepared films, the pectin film containing acerola extract afforded the highest antioxidant capacity, with a half‐life of 99 d. Overall, the results revealed that incorporation of fruit extracts into pectin films potentially produces antioxidant films and coatings for different food applications. 相似文献
9.
Voltaire Sant’Anna Michele Utpott Florencia Cladera-Olivera Adriano Brandelli 《Food and Bioprocess Technology》2013,6(1):73-79
In the present work, the influence of pH and sodium chloride concentration on thermal stability of antimicrobial peptide P34 was evaluated under different time–temperature conditions by a 22 factorial design experiment. At sterilization conditions (121 °C for 20 min), maximum retention (36%) was obtained at pH between 5.5 and 8.5 and sodium chloride concentration between 0.4 and 0.75 mol/l. For boiling conditions (100 °C for 20 min), antimicrobial activity was about 100% combining pH between 6.0 and 8.0 and salt concentration in the range of 0.65 to 1 mol/l. At low temperature pasteurization conditions (30 min at 65 °C), antimicrobial activity was not affected within the pH range from 5.0 to 8.0. For the three time–temperature conditions tested, the antimicrobial activity was minimal at more acidic or alkaline pH. Sodium chloride concentration of 0.65 mol/l increased thermostability of the peptide P34. Combination of sodium chloride and slight alkaline pH may increase the stability of peptide P34, which is essential to the proper utilization of bacteriocins in food industry. 相似文献
10.
Dar Reuven; Stronguin Florencia; Etter Jean-Francois 《Canadian Metallurgical Quarterly》2005,73(2):350
In this report, the authors explore the relationships of perceived treatment to outcome in a large, placebo-controlled trial of nicotine replacement treatment for smoking reduction. In the original study (J. F. Etter, E. Laszlo, J. P. Zellweger, C. Perrot, & T. V. Perneger, 2002), which was conducted in French-speaking Switzerland, smokers were randomly assigned to receive nicotine, matching placebo products, or no intervention. At the end of the 6-month study, participants were asked to guess whether they had received nicotine or placebo. In the present analysis, the authors examined the difference in smoking reduction between those who believed they had received nicotine and those who believed they had received placebo. Regardless of actual treatment, smokers who believed they had received nicotine had significantly better outcome than those who believed they had received placebo. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献