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1.
The mammalian cell cycle is important in controlling normal cell proliferation and the development of various diseases. Cell cycle checkpoints are well regulated by both activators and inhibitors to avoid cell growth disorder and cancerogenesis. Cyclin dependent kinase 20 (CDK20) and p21Cip1/Waf1 are widely recognized as key regulators of cell cycle checkpoints controlling cell proliferation/growth and involving in developing multiple cancers. Emerging evidence demonstrates that these two cell cycle regulators also play an essential role in promoting cell survival independent of the cell cycle, particularly in those cells with a limited capability of proliferation, such as cardiomyocytes. These findings bring new insights into understanding cytoprotection in these tissues. Here, we summarize the new progress of the studies on these two molecules in regulating cell cycle/growth, and their new roles in cell survival by inhibiting various cell death mechanisms. We also outline their potential implications in cancerogenesis and protection in heart diseases. This information renews the knowledge in molecular natures and cellular functions of these regulators, leading to a better understanding of the pathogenesis of the associated diseases and the discovery of new therapeutic strategies. 相似文献
2.
Effect of complexation of oxidised corn starch with mineral elements on physicochemical properties
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Sławomir Pietrzyk Teresa Fortuna Lesław Juszczak Dorota Gałkowska Karolina Królikowska Karolina Zięba 《International Journal of Food Science & Technology》2015,50(4):934-941
The objective of this study was to determine the effect of complexation of oxidised starch with mineral elements on its physicochemical properties. Corn starch was oxidised with sodium hypochlorite and, afterwards, modified with ions of potassium, magnesium and iron. Thus, native and modified starches were analysed for: contents of mineral elements, colour parameters (L*a*b*), water binding capacity and solubility in water at temperature of 60 and 80 °C. Thermodynamic characteristics of gelatinisation by DSC, molecular weight distribution by GPC, intrinsic viscosity and pasting properties by RVA were studied. The efficiency of incorporation of metal ions into oxidised corn starch was about 30%, 20% and 20% for potassium, magnesium and iron ions, respectively. The complexation with potassium ions caused the greatest changes in the molecular weight distribution and the intrinsic viscosity of starches and viscosity of starch pastes. Only modification of starch with iron ions affected the colour parameters of the starch. Incorporation of metal ions into starch resulted also in changes in its water binding capacity and solubility in water. 相似文献
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Ga -Er Yu J. Parrick M. Edirisinghe D. Finch B. Ralph 《Journal of Materials Science》1994,29(6):1680-1685
Proton nuclear magnetic resonance (1H NMR) spectroscopy, Fourier transform infrared (FT-IR) spectroscopy and gas chromatography (GC) have been used to study the products of ammonolysis of dichloromethylsilane in diethyl ether at 0 °C. Results indicate that the major products are trimethylcyclotrisilazane and tetramethylcyclotetrasilazane. Hydrolysis of the cyclosilazanes has also been qualitatively investigated. A simple and useful method for the identification of cyclosilazanes has been developed using the 1H NMR technique. 相似文献
5.
P. Lobotka I. Vávra Š. Gaži A. Plecenik J. Dérer 《Journal of Low Temperature Physics》1997,106(3-4):381-386
A Josephson junction Nb/Si/Nb with a 10 nm thick amorphous silicon barrier is studied. The upper electrode contains a 2 nm
thick sublayer of amorphous phase adjacent to the barrier, as revealed by cross-sectional TEM. Thus, the junction can be considered
as a S-I-N-S system with the N layer represented by amorphous niobium. Peculiarities in the I–V and Δ(T) dependencies are
observed and explained as a consequence of a proximity effect present in the upper electrode. 相似文献
6.
J. P. Emelianova P. V. Pakshin K. Gałkowski E. Rogers 《Automation and Remote Control》2014,75(5):845-858
This paper considers systems with two-dimensional dynamics (2D systems) described by the continuous-time nonlinear state-space Roesser model. The sufficient conditions of exponential stability in terms of vector Lyapunov functions are established. These conditions are then applied to analysis of the absolute stability of a certain class of systems comprising a linear continuous-time plant in the form of the Roesser model with a nonlinear characteristic in the feedback loop, which satisfies quadratic constraints. The absolute stability conditions are reduced to computable expressions in the form of linear matrix inequalities. The obtained results are extended to the class of continuous-time systems governed by the Roesser model with Markovian switching. The problems of absolute stability and stabilization via state- and output-feedback are solved for linear systems of the above class. The solution procedures for these problems are in the form of algorithms based on linear matrix inequalities. 相似文献
7.
树脂相分光光度法测定人发中痕量铜 总被引:1,自引:0,他引:1
研究了铜与钛铁试剂在pH=9.00的碱性介质中反应生成有色络合物,与717#强碱性阴离子交换树脂交换吸附,在树脂相下进行光度分析的方法。铜树脂相络合物的最大吸收波长为375um;表观摩尔吸光系数ε为6.4×104L·mol(-1)·cm(-1);符合Beer定律的范围为0~1.6mg·L(-1)。此法用于人发中痕量钢的测定,结果令人满意。 相似文献
8.
Boris Raymond Gaël Guennebaud Pascal Barla Romain Pacanowski Xavier Granier 《Computer Graphics Forum》2014,33(2):313-321
This paper introduces a system for the direct editing of highlights produced by anisotropic BRDFs, which we call anisotropic highlights. We first provide a comprehensive analysis of the link between the direction of anisotropy and the shape of highlight curves for arbitrary object surfaces. The gained insights provide the required ingredients to infer BRDF orientations from a prescribed highlight tangent field. This amounts to a non‐linear optimization problem, which is solved at interactive framerates during manipulation. Taking inspiration from sculpting software, we provide tools that give the impression of manipulating highlight curves while actually modifying their tangents. Our solver produces desired highlight shapes for a host of lighting environments and anisotropic BRDFs. 相似文献
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10.
Front cover: MALDI mass spectrometry imaging: A cutting‐edge tool for fundamental and clinical histopathology
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