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排序方式: 共有688条查询结果,搜索用时 15 毫秒
1.
Bokyung Kim Young Ho Ko Massimiliano Runfola Simona Rapposelli Gabriella Ortore Grazia Chiellini Jin Hae Kim 《International journal of molecular sciences》2021,22(7)
Thyromimetics, whose physicochemical characteristics are analog to thyroid hormones (THs) and their derivatives, are promising candidates as novel therapeutics for neurodegenerative and metabolic pathologies. In particular, sobetirome (GC-1), one of the initial halogen-free thyromimetics, and newly synthesized IS25 and TG68, with optimized ADME-Tox profile, have recently attracted attention owing to their superior therapeutic benefits, selectivity, and enhanced permeability. Here, we further explored the functional capabilities of these thyromimetics to inhibit transthyretin (TTR) amyloidosis. TTR is a homotetrameric transporter protein for THs, yet it is also responsible for severe amyloid fibril formation, which is facilitated by tetramer dissociation into non-native monomers. By combining nuclear magnetic resonance (NMR) spectroscopy, computational simulation, and biochemical assays, we found that GC-1 and newly designed diphenyl-methane-based thyromimetics, namely IS25 and TG68, are TTR stabilizers and efficient suppressors of TTR aggregation. Based on these observations, we propose the novel potential of thyromimetics as a multi-functional therapeutic molecule for TTR-related pathologies, including neurodegenerative diseases. 相似文献
2.
Gökelma Mertol Einarsrud Kristian Etienne Tranell Gabriella Friedrich Bernd 《Metallurgical and Materials Transactions B》2020,51(2):850-860
Metallurgical and Materials Transactions B - The quality requirements of aluminum products are steadily increasing, and the presence of non-metallic inclusions have a large impact on the quality of... 相似文献
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In this work a new class of numerical methods for the BGK model of kinetic equations is presented. In principle, schemes of
any order of accuracy in both space and time can be constructed with this technique. The methods proposed are based on an
explicit–implicit time discretization. In particular the convective terms are treated explicitly, while the source terms are
implicit. In this fashion even problems with infinite stiffness can be integrated with relatively large time steps. The conservation
properties of the schemes are investigated. Numerical results are shown for schemes of order 1, 2 and 5 in space, and up to
third-order accurate in time. 相似文献
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Impedance spectroscopy and gravimetry were employed to characterize alkyd-acrylate and styrene-acrylate water-borne resin film properties during wetting-through (i.e. during water uptake). 相似文献
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Summary Poly(glycidyl azide), PGA, was grafted onto Hydroxyl Terminated Poly(butadiene), HTPB, via free radical mechanism. PGA-macro azoinitator and HTPB polymer mixture was casted from solution and the polymer film was kept at 90°C for 4 hours. The grafted polymer was isolated from the product by fractional precipitation and characterized by NMR and FT-IR spectroscopy. Graft copolymer structure was also confirmed that volume ratio of nonsolvent to the solution of the graft copolymer was between those of corresponding homopolymers. TGA traces of the block polymers were containing two different maxima at 253°C (for PGA units) and 469°C (for HTPB units). Because of the incompatibility of the blocks, DSC curve showed two Tg's which belong to the related segments. 相似文献
8.
Sibel Akgün Gülsüm Ekici Nilüfer Mutlu Necati Beşirli Baki Hazer 《Journal of Polymer Research》2007,14(3):215-221
Modification of chitosan by grafting of vinyl butyrate was carried out in homogeneous phase using potassium persulfate as
redox initator and 1.5% acetic acid as solvent. The percent grafting and grafting efficiency were analysed and the high grafting
efficiency up to 94% was observed. The effects of reaction variables such as monomer concentration, initiator concentration,
temperature and reaction time were investigated. It was observed that the solubility of chitosan was markedly reduced after
grafting with vinyl butyrate. The grafted product is insoluble in common organic solvents as well in dilute organic and inorganic
acids. Characterization of the graft copolymers were carried out by using Fourier Transform Infrared Spectroscopy (FTIR),
Differential Scanning Calorimetry (DSC) and Scanning Electron Microscopy (SEM) technics. Characteristic signal of carbonyl
group was observed at 1,731 cm−1 which belongs to the poly vinyl butyrate segments in the graft copolymer. The melting transition of the chitosan main chain
in the copolymer shifted to 124°C from its original value 101°C. In addition to these, we have also studied topology of the
graft copolymer and the SEM micrograph showed continuous homogenous matrix which means there is no phase separation. 相似文献
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This paper applies cognitive models, inspired by cognitive science, with the aim to propose architectural and knowledge‐based requirements to structure ontological models for the cognitive profiling of agents. The proposed architecture aims to address the lack of flexibility that most agent‐based collaborations are affected by. The resulting agents, equipped with advanced cognitive profiling, have an increased cognitive awareness of themselves and are more capable of interacting with other agents in a multi‐agents based environment. In this research, cognitive awareness identifies the ability of the web agents to diagnose their processing limitations and to establish interactions with the external environment. The outcome is the enhanced flexibility, reusability and predictability of the agent behaviour; thus contributing towards minimizing human cognitive demands. The concept of cognitive profiling presented in this paper considers the semantic web as an action mediating space, where ontological models provide affordances for improving cognitive awareness through shared knowledge‐base. The conceptual model for the cognitive profile architecture is developed with Protégé Ontology editor to generate OWL Ontology and evaluated through a proof of concept. The results show that agents equipped with cognitive awareness can undertake complex tasks more dynamically. 相似文献