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排序方式: 共有171条查询结果,搜索用时 6 毫秒
1.
Đurović Gordana Van Neerbos Francine A. C. Bossaert Sofie Herrera-Malaver Beatriz Steensels Jan Arnó Judit Wäckers Felix Sobhy Islam S. Verstrepen Kevin J. Jacquemyn Hans Lievens Bart 《Journal of chemical ecology》2021,47(8-9):788-798
Journal of Chemical Ecology - There is increasing evidence that microorganisms, particularly fungi and bacteria, emit volatile compounds that mediate the foraging behaviour of insects and therefore... 相似文献
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Dr. Andrija Smelcerovic Dr. Jelena Lazarevic Katarina Tomovic Marija Anastasijevic Dr. Marko Jukic Dr. Gordana Kocic Dr. Marko Anderluh 《ChemMedChem》2019,14(5):514-521
Due to uncomfortable injection regimens of peptidic agonists of glucagon-like peptide-1 receptor (GLP-1R), orally available nonpeptide positive allosteric modulators (PAMs) of GLP-1Rs are foreseen as the possible future mainstream therapy for type 2 diabetes. Herein, current GLP-1R PAMs are reviewed. Based on the effectiveness and in silico predicted physicochemical properties, pharmacokinetics, and toxicity, possible candidates for further development as oral drugs were selected. The suggestion is that GLP-1R PAMs might be used orally alone or in combination with dipeptidyl peptidase-4 (DPP-4) inhibitors, which could offer an optimal treatment option next to metformin monotherapy in type 2 diabetes mellitus, or in a wider spectrum of indications. Quercetin acts as a GLP-1R PAM and DPP-4 inhibitor, and therefore, might be considered as a pioneering agent with a dual mechanism of action, in terms of GLP-1R positive allosteric modulation and DPP-4 inhibition for potentiating GLP-1 dependent effects. 相似文献
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Neural Computing and Applications - In the paper, the authors elaborate a recent research concerning the originality of artworks in terms of self-organization in the complex systems physics. It has... 相似文献
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This paper presents a novel two-stage class of decimation filters with superior spurious signal rejection performance around the so-called folding bands, i.e., frequency intervals whose signals get folded down to baseband due to decimation. The key idea to enhance signal rejection in the frequency domain lies on an effective way to place the zeros of a classical comb filter in the aforementioned folding bands. On the other hand, the paper provides a mathematical framework for designing two-stage multiplierless and nonrecursive structures of the proposed filters.Examples are provided to highlight the key steps in the design of the proposed filters. Moreover, the frequency behavior of the proposed filters in both baseband and stopband is compared with classical and generalized comb filters, and a droop compensator is proposed to counteract the passband distortion of the proposed filters. 相似文献
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Biosorption of nickel ions from aqueous solutions by natural and modified peanut husks: equilibrium and kinetics 下载免费PDF全文
Katerina Atkovska Burevska Hamdije Memedi Kiril Lisichkov Stefan Kuvendziev Mirko Marinkovski Gordana Ruseska Anita Grozdanov 《Water and Environment Journal》2018,32(2):276-284
The toxicity and non‐biodegradation of heavy metals, as well as their tendency to accumulate in the soils, water resources and the living organisms, makes them the significant environmental pollutants. Therefore, the reduction and elimination of heavy metal ions from aqueous systems is very important from the ecological, nutritional and environmental reasons. The aim of this study is to investigate whether the natural peanut husks, an agricultural waste, and their chemically modified form are capable to remove Ni(II) ions from aqueous solutions using batch method and to compare their efficiency. The effects of the mass of the natural peanut husks and the initial pH of the solution were studied to find the optimal conditions for maximal removal of Ni(II) ions. MATLAB/Curve Fitting Toolbox was implemented to determine the adequate adsorption isotherm as well as to optimise the equilibrium state of the investigated systems. 相似文献
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This article presents a review of glyph-based techniques for engineering visualization as well as practical application for the multivariate visualization process. Two glyph techniques, Chernoff faces and star glyphs, uncommonly used in engineering practice, are described, applied to the selected data set, run through the chosen optimization methods and user evaluated. As an example of how these techniques function, a set of data for the optimization of a heat exchanger with a microchannel coil is adopted for visualization. The results acquired by the chosen visualization techniques are related to the results of optimization carried out by the response surface method and compared with the results of user evaluation. Based on the data set from engineering research and practice, the advantages and disadvantages of these techniques for engineering visualization are identified and discussed. 相似文献
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Gordana Dodig-Crnkovic 《AI & Society》2013,28(3):319-327
We are living in an era when the focus of human relationships with the world is shifting from execution and physical impact to control and cognitive/informational interaction. This emerging, increasingly informational world is our new ecology, an infosphere that presents the grounds for a cognitive revolution based on interactions in networks of biological and artificial, intelligent agents. After the industrial revolution, which extended the human body through mechanical machinery, the cognitive revolution extends the human mind/cognition through information-processing machinery. These novel circumstances come with new qualities and preferences demanding new conceptualizations. We have some work ahead of us to establish value systems and practices extended from the real to the increasingly virtual/info-computational. This paper first presents a current view of the virtual versus the real and then offers an interpretation framework based on an info-computational understanding of cognition in which agency implies computational processing of informational structures of the world as an infosphere. The notion of “good life” is discussed in light of different ideals of well-being in the infosphere, connecting virtuality as a space of potential and alternative worlds for an agent for whom the reality is a space of actual experiences, in the sense of Deleuze. Even though info-computational framework enables us to see both the real world and the diversity of virtual worlds in terms of computational processes on informational structures, based on a distinct layered cognitive architecture of all physical agents, there is clear difference between potential worlds of the virtual and actual agent’s experiences made in the real. Info-computationalism enables insight into the mechanisms of infosphere and elucidates its importance as cognitively predominant environment and communication media. The conclusion is that by cocooning ourselves in an elaborate info-computational infrastructure of the virtual, we may be increasingly isolating ourselves from the reality of direct experience of the world. The biggest challenges of the cognitive revolution may not be technological but ethical. They are about the nature of being human and its values. 相似文献
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Marija Kuzmanovic Gordana Savic Bisera Andric Gusavac Dragana Makajic-Nikolic Biljana Panic 《Expert systems with applications》2013,40(10):4083-4089
In recent years, the need for greater accountability and improvement in teaching’s quality has become a major issue in higher education. The results of student evaluation of teaching are increasingly used to make judgments about teaching quality, career advancement, and the funding of teaching itself. An important component of any such student evaluation is the communication of rating results in a manner that allows for fair and meaningful interpretations and comparisons of results by a wide range of evaluation users. In this paper, an approach for a more objective evaluation of university teachers is proposed, one which is based on previously obtained conjoint analysis data concerning criteria importance from a student’s point of view. Therein, an illustrative example is given to demonstrate the efficiency and practical usage of such a proposed approach. 相似文献
10.
The synthesis, FT-IR, 1H and 13C NMR characterisation, as well as crystal and molecular structure determined by single-crystal X-ray diffraction data, of two azo dyes derived from 6-aminobenzothiazole: 6-[(4-N,N-dimethylaminophenyl)diazenyl]benzothiazole and 6-[(2-hydroxy-1-naphthyl)diazenyl]benzothiazole are reported. Both dyes are essentially planar with the exclusion of methyl groups in 6-[(4-N,N-dimethylaminophenyl)diazenyl]benzothiazole, which exibits 100% E-configuration in terms of orientation of the substituents about the central azo linkage. Single-crystal X-ray study of 6-[(2-hydroxy-1-naphthyl)diazenyl]benzothiazole was undertaken to established whether the hydrazone or azo tautomer was present in the solid state as well as any potential shift in tautomeric equilibrium imparted by temperature variation (296 and 100 K). Density functional theory calculations revealed that the hydrazone tautomer was more stable than the azo tautomer and that the tautomeric equilibrium was shifted towards the hydrazone form at lower temperature. 相似文献