Ferroelastic domain structure and phase transition in single-crystalline [PbZn1/3Nb2/3O3]1-x[PbTiO3]x observed via in situ x-ray microbeam

(1-x)Pb(Zn_1/3Nb_2/3)O₃-xPbTiO₃ ((1-x)PZN-xPT in short) is one of the most important piezoelectric materials. In this work, we extensively investigated (1-x)PZN-xPT (x = 0.07–0.11) ferroelectric single crystals using in-situ synchrotron μXRD, complemented by TEM and PFM, to correlate microstructures with phase transitions. The results reveal that (i) at 25 °C, the equilibrium state of (1-x)PZN-xPT is a metastable orthorhombic phase for x = 0.07 and 0.08, while it shows coexistence of orthorhombic and tetragonal phases for x = 0.09 and x = 0.11, with all ferroelectric phases accompanied by ferroelastic domains; (ii) upon heating, the phase transformation in x = 0.07 is Orthorhombic → Monoclinic → Tetragonal → Cubic. The coexistence of ferroelectric tetragonal and paraelectric cubic phases was in-situ observed in x = 0.08 above Curie temperature (T_C), and (iii) phase transition can be explained by the evolution of the ferroelectric and ferroelastic domains. These results disclose that (1-x)PZN-xPT are in an unstable regime, which is possible factor for its anomalous dielectric response and high piezoelectric coefficient.     

Development of porous defects in plasma membranes of adenosine triphosphate-depleted Madin-Darby canine kidney cells and its inhibition by glycine

Studies during the past decade have led to the recognition of a fundamental, widely expressed mechanism of structural damage in energy-deprived cells, which is suppressed by physiologic levels of glycine and is independent of Ca2+ availability or alterations of cytosolic free Ca2+. To gain insight into this process, Madin-Darby canine kidney (MDCK) cells were depleted of adenosine triphosphate (ATP) by a mitochondrial uncoupler in glucose-free medium, and intracellular free Ca2+ was clamped at 100 nM to avoid calcium cytotoxicity. Although the ATP-depleted cells swelled and blebbed and their plasma membranes appeared to be under tension, they nevertheless became permeable to macromolecules. The plasma membranes of these cells retained structural continuity, as determined by morphologic observations, and confocal microscopy of a plasma membrane protein label (Biotin: Ultra Avidin-Texas Red) and a lipid label (NBD-sphingomyelin). Using fluoresceinated dextrans of graded molecular size, membrane permselectivity was examined noninvasively by confocal microscopy. Measured as inside/outside ratios of fluorescence intensity, the permeability indices showed progressively greater restriction to diffusion of increasingly larger dextran molecules across plasma membranes, with sharp break-points between 70,000 and 145,000 daltons (d). The results indicated that the membranes behaved as if they were perforated by water-filled channels or "pores," with size-exclusion limits of molecular dimensions. The membrane defects evolved from small pores permeable only to propidium iodide (668 d) and the smallest dextran (4,000 d), before enlarging with time to become permeable to larger dextrans. Inclusion of glycine during ATP depletion did not affect cell swelling or blebbing but completely prevented the development of permeability defects. Treatment of cells before ATP depletion with a membrane-impermeant homobifunctional "nearest neighbor" cross-linking agent, 3,3' dithiobis(sulfosuccinimidylpropionate), suppressed the development of permeability defects, even in the absence of glycine. These observations suggest that the cellular abnormality that is suppressed by glycine involves rearrangement of plasma membrane proteins to form water-filled pores large enough to leak macromolecules.     

Synthesis and characterization of castor oil urethane triamine networks

Castor oil was polymerized with diisocyanate and crosslinked with primary triamine (Jeffamine T-403) to form networks. The effect of triamine as a crosslinking agent on rubbery castor oil urethane elastomer was determined by measuring network parameters such as average molecular weight between crosslinks (MC) number of polymer chains per unit volume (N), tensile strength, and modulus of the networks. The crosslinking density was varied by varying the ratio of NCO : NH₂ from 0.60 to 0.95. The results indicated the formation of highly crosslinked elastomers at all NCO : NH₂ ratios employed. The tensile stregth and modulus increased with increasing crosslink density up to a value of NCO : NH₂ 0.85 and after this there was no significant change, indicating the maximum limit of improvement attainble in terms of network characteristics.     

Parameter Selection Based on Surface Finish in High-Speed End-Milling Using Differential Evolution

Selection of cutting parameters in high-speed machining is one of the most important tasks to achieve the required level of quality. Evolutionary algorithms are often used to obtain the optimal parameters corresponding to a single value of surface finish. In most practical applications, it is necessary to determine the cutting speed, feed, and depth of cut to meet the required surface finish. In the present work, high-speed end-milling has been studied, and an objective function for surface finish is obtained by Response Surface Methodology using results of carefully designed experiments. Testing of differential evolution and genetic algorithms using the classical Himmelblau function reveals that the performance of differential evolution is better. Therefore, differential evolution is used in the present work with a newly proposed objective function, and the machining parameters for the required surface finish are obtained.     

The structure and dynamics of microparticles at pickering emulsion interfaces

We have employed a laser scanning confocal microscope (LSCM) to study the structure and dynamics of microparticles at Pickering emulsion interfaces. The microparticles can have rich morphology at the emulsion interfaces, ranging from an aggregated structure to colloidal lattices, with a possibility of involving heterogeneous particles. With a specific interest in colloidal lattices, we find that although the enhanced electrostatic repulsion explains the formation of colloidal lattices by sulfate-treated polystyrene (S-PS) particles, it fails to interpret the unsuccessfulness of assembling lattices containing single-species carboxylate-treated polystyrene (C-PS) particles. A small percentage of C-PS particles in the colloidal mixture does not disturb the formation of lattices made of S-PS particles. The LSCM also provides a meaningful way to probe dynamic information. The diffusion of single particles at the emulsion interfaces depends strongly on the oil phase viscosity, particle size, and particle wettability. A highly curved emulsion interface slows the motion of microparticles at oil-water interfaces but the interface curvature effect decreases with increasing oil phase viscosity. Although the confocal microscope was originally used as an imaging tool, we find that the thermodynamic equilibrium of colloidal lattices can be disturbed and even destroyed when increasing the output laser intensity.     

Parasitic capacitance removal of sub-100 nm p-MOSFETs using capacitance–voltage measurements

Capacitance–voltage measurements are performed on sub-100 nm high-k/metal gate p-MOSFETs to extract the intrinsic capacitance per gate length. This is then repeated on simulated devices using finite element modeling to compare to the experimental results. The intrinsic channel capacitance for the simulated devices is isolated from the parasitic capacitance, allowing for the comparison of analytic models of parasitic capacitances to the simulation.     

Critical issues related to transfersomes - novel vesicular system

It has become increasingly apparent that vesicular drug delivery elicits modest possessions in drug targeting. Transfersomes are a form of elastic or deformable vesicle, which were first introduced in the early 1990s. Elasticity can be achieved by using an edge activator in the lipid bilayer structure. Molecules greater than 500 Da normally do not cross the skin. This prevents epicutaneous delivery of the high molecular weight therapeutics as well as non-invasive transcutaneous immunisation. Transdermal route will always remain a lucrative area for drug delivery. With the advent of new categories of drugs like peptides this route has captured more focus to combat the problems related to their delivery through oral route. But the transdermal route is equally filled with the hopes and disappointments as the transport of drug through this route faces many problems especially for the large molecules. To answer this problem many approaches were adopted. One of the very recent approaches is the use of ultra-deformable carrier systems (transfersomes). They have been used as drug carriers for a range of small molecules, peptides, proteins and vaccines, both in vitro and in vivo. Transfersomes penetrate through the pores of stratum corneum which are smaller than its size and get into the underlying viable skin in intact form. This is because of its deformable nature. The aim of this article is explanation the formation of micelle and vesicles, various types of vesicles, specifically focusing on transfersomes.     

Development of a feed rate adaption control system for high-speed rough and finish end-milling of hardened EN24 steel

High-speed machining centers are used for end-milling operations of a variety of parts, dies, and molds needed in power and transport industries. Different approaches are used for rough and finish end-milling, since desired productivity and quality are important in the respective cases. In the present work, a feed rate adaption control system is proposed by integrating different requirements of high-speed end-milling. Hardened EN 24 steel which is being widely used in the production of dies, molds, and other parts is taken as a candidate work material for implementation of the proposed control system. Based on extensive experimentation, investigations have been carried out on high-speed rough and finish end-milling operations, and the details are reported by the authors (Saikumar and Shunmugam, Int J Adv Manuf Technol, under review). In this paper, relevant response surface and artificial neural network models have been used, and suitable reference parameters are obtained for the proposed control system. In the case of rough end-milling, material removal volume is taken as the objective, and the reference values for cutting force and cutting time are used. Only a reference cutting force is used for finish end-milling in which surface roughness is considered as the objective. Implementation details of the proposed PC-based control system are presented. The results obtained for a newly devised H–A–S–H test (short run) along with those for long-run tests are presented and discussed.     

Investigations into high-speed rough and finish end-milling of hardened EN24 steel for implementation of control strategies

High-speed end-milling is used for production of variety of parts, dies, and molds made of hardened EN24 steel which are widely used in power and transport industries. Since desired productivity and quality are important in these industries, different strategies are needed for rough and finish end-milling operations. In this paper, a framework is presented for integrating different requirements of high-speed end-milling. In flat end-milling experiments, slots are machined in hardened EN24 steel using single insert cutter under different sets of cutting parameters for roughing and finishing operations. For rough end-milling, the responses such as material removal volume, tool wear and cutting forces are measured with respect to cutting time. A response surface is developed to predict material removal volume and a set of cutting parameters is selected for a given range of material removal volume using differential evolution (DE) algorithm till the tool wear reaches certain value. The experimental data is also used to develop Bayesian-based artificial neural network (ANN) model. Using this ANN model, reference values for cutting force and cutting time are generated for rough end-milling. Similarly, DE is used to predict a set of cutting parameters for a given range of surface roughness using response surface model. The reference cutting force is obtained for finish end-milling using ANN model. These reference values are useful in the monitoring and implementation of control strategy for the high-speed end-milling operations.