Energy Recovery in Pressurized Hydraulic Networks

Water Resources Management - This paper aims to evaluate the possibility of using non-utilized hydraulic energy in urban water distribution systems. For this purpose, the viability and possible...     

Intrauterine transfusions influence fetal leukocyte counts and subsets

Histamine is an important mediator in allergic reactions, gastric acid secretions, and neurotransmission in the central nervous system. Basophils and mast cells are the main sources of histamine, which is formed from L-histidine by histidine decarboxylase (HDC). However, the regulatory mechanism of HDC in these cells remains unclear. We examined the regulation of HDC activity and gene expression using a unique human mast cell line, HMC-1, after stimulation with phorbol 12-myristate 13-acetate (PMA) or ionomycin. HDC activity was increased from 52.1+/-0.4 (mean+/-standard deviation) to 154+/-6.9, or 105.6+/-6.2 pmol/min/mg protein (n = 3), 4 hours after stimulation with PMA (10 ng/mL) or ionomycin (10[-6] M). Although actinomycin D had no effect on this increase, cycloheximide completely inhibited the increase caused by these stimuli. The population of HMC-1 cells containing HDC protein was increased after stimulation with either PMA or ionomycin as evaluated by immunocytochemical analysis with anti-HDC antibody as a marker. HMC-1 constitutively expressed HDC mRNA, and its level was not increased with these stimuli. These results suggest that the increase of HDC activity in HMC-1 induced by PMA or ionomycin is regulated at the translational level.     

Dielectric barrier discharge treatments at atmospheric pressure for wood surface modification

In this research, the effect of dielectric barrier discharge on mechanically manufactured (sawn, planed or polished) wood surfaces is investigated. The experiments have shown that the best hydrophilia is obtained with a cold plasma discharge in air under atmospheric pressure. Other gases such as helium, nitrogen, and argon have been tested, too. Changes of the wood surface properties were determined by absorption of water and contact angle measurements. As a result of a 1 to 20 seconds long exposure to plasma, wood surfaces became hydrophilic. The absorption of water in wood can be changed up to 22 times higher after plasma treatment in air for 20 seconds duration. The fracture strength of glued wood has been increased by 68% after this plasma pretreatment. Using plasma treatment in methane or acetylene wood surfaces are changed to hydrophobic properties. After plasma treatment for 1 min. in a Ar:CH₄=80:20 gas mixture under atmospheric pressure, the absorption of water in wood is 32 times lower than without plasma treatment. As mentioned before, plasma treatment can produce hydrophobic and hydrophilic wood surfaces. But a good homogeneity of the gas discharge is necessary for the plasma treatment of wood. Zusammenfassung Im Rahmen dieser Arbeit werden die Auswirkungen der dielektrisch behinderten Entladung bei Atmosphärendruck auf mechanisch bearbeitete Holzoberflächen (gesägt, gehobelt oder geschliffen) untersucht. Die Experimente haben gezeigt, dass die höchste Hydrophilität bei einem in Luftatmosphäre gezündetem Plasma erreicht wird. Es werden auch andere Gase verwendet, wie z.B. Helium, Stickstoff und Argon. Zur Untersuchung der veränderten mechanischen und energetischen Eigenschaften der Holzoberflächen werden der Tropfen-Versuch und die Kontaktwinkelmessung verwendet. Durch eine 1 bis 20 Sekunden lange Plasmabehandlung können die Oberflächen hydrophil gestaltet werden. So kann die Eindringzeit von Wasser um Faktor 22 gesteigert werden durch eine 20 Sekunden lange Plasmabehandlung in Umgebungsluft. Die Bruchfestigkeit von Leimholz wird durch die gleiche Plasmavorbehandlung um 68% gesteigert. Werden als Plasmabehandlungsgas Methan oder Acetylen eingesetzt, so wird die Holzoberfläche hydrophob. Durch eine 60 Sekunden lange Plasmabehandlung in einem Ar:CH₄=80:20 Gasgemisch bei Atmosphärendruck wird die Eindringszeit von Wasser um den Faktor 32 gesenkt. Mit Hilfe der Plasmabehandlung können also sowohl hydrophobe als auch hydrophile Holzoberflächen erzeugt werden. Jedoch wird für die Plasmabehandlung von Holz eine sehr homogene Gasentladung benötigt.     

CHOP vs. ProMACE-CytaBOM in the treatment of aggressive non-Hodgkin's lymphomas: long-term results of a multicenter randomized trial.(PETHEMA: Spanish Cooperative Group for the Study of Hematological Malignancies Treatment, Spanish Society of Hematology)

From May 1985 to May 1989, 175 patients with previously untreated aggressive non-Hodgkin's lymphoma were randomized to receive CHOP or ProMACE-CytaBOM. Eligibility criteria included follicular large-cell diffuse small cleaved-cell, diffuse mixed, diffuse large-cell and immunoblastic lymphoma with an Ann Arbor stage II, III or IV. One hundred and forty-eight patients were evaluable. There were no significant differences between the 2 treatments in response rate (83.5% [57.5% CR] for CHOP vs. 88% [62% CR] for ProMACE-CytaBOM), time to treatment failure (29% vs. 31% at 5 yr), or overall survival (42% in both groups at 5 yr). Furthermore, there were no significant differences between the 2 regimens when response rates and outcome were analyzed for different prognostic subgroups. Toxicity was not significantly different between the 2 regimens, although only 1 patient died as result of treatment-related toxicity in the CHOP arm compared to 6 patient in the ProMACE-CytaBOM group (p = 0.126). In conclusion, in this study ProMACE-CytaBOM has not proved to be superior to CHOP in aggressive lymphomas. This trial gives support to the notion that CHOP still is the standard chemotherapy for aggressive lymphomas, and that new treatment approaches for these lymphomas should be compared to CHOP.     

The Influence of Medium on Low-Voltage Circuit Breaker Arcs

This paper mainly focuses on the influence of three kinds of media： air, air-10%PA （Nylon） and air-10% POM （polyoxymethylene） on low-voltage circuit breaker arcs. A threedimensional （3-D） model of arc motioa under the effect of external magnetic field is built based on magnetohydrodynamics （MHD） equations. By adopting the commercial computational fluid dynamics （CFD） package based on the control-volume method, the above MHD equations are solved. For the media of air-10%PA and air-10%POM, the distributions of stationary temperature and electrical potential and the transient motion processes are compared with those of air arc. The research shows that both air-10%PA and air -10% POM can cool the arc plasma and the former is more effective. Both of them can increase the stationary voltage as well. Moreover, the presence of the two mixtures can accelerate the arc motion toward the quenching area and ensures the arc quenched in time.     

Designing collaborative,constructionist and contextual applications for handheld devices

This paper explores current applications for handheld devices and questions which of these make full use of the unique attributes of handheld devices in order to facilitate learning in a pedagogically sensible manner. In order to do so, the paper presents a functional framework which analyses handheld application in relation to their use as well as the pedagogical underpinning, if any, that informs their development. Our framework currently consists of seven distinct categories of application, which we term: administrative, referential, interactive, microworld, data collection, location aware and collaborative. We argue that three categories, namely data collection, location aware and collaborative, are particularly suited to learning with handheld devices when they are informed by collaborative, contextual and constructionist learning theories. Furthermore, we contend that applications of the type just outlined deserve further research since they are not attempting to replicate, or even augment, existing learning scenarios but rather they try to create new learning opportunities which would not be possible without (mobile) technology. Finally, the authors introduce a number of applications and learning scenarios that they have developed for handheld devices and explain their position within the framework.     

P16 and HPV Genotype Significance in HPV-Associated Cervical Cancer—A Large Cohort of Two Tertiary Referral Centers

The expression of p16 is a good surrogate of human papillomavirus (HPV) infection in HPV-associated cancers. The significance of p16 expression, HPV genotype and genera in the outcome of patients with HPV-associated cervical cancer (CC) is unclear. Our aim is to ascertain the prognostic significance of these factors. Data from 348 patients (median age: 47.5 years old) with CC, diagnosed in two referral centers, were retrospectively collected. Advanced disease (FIGO2018 IB2-IV) was present in 68% of patients. A single HPV genotype was identified in 82.8% of patients. The most common HPVs were HPV16 (69%) and HPV18 (14%). HPV genera reflected this distribution. HPV16 tumors presented at an earlier stage. P16 was negative in 18 cases (5.2%), 83.3% of which were squamous cell carcinomas. These cases occurred in older patients who tended to have advanced disease. In the univariate analysis, HPV16 (HR: 0.58; p = 0.0198), α-9 genera (HR: 0.37; p = 0.0106) and p16 overexpression (HR: 0.54; p = 0.032) were associated with better survival. HPV16 (HR: 0.63; p = 0.0174) and α-9 genera (HR: 0.57; p = 0.0286) were associated with less relapse. In the multivariate analysis, only the International Federation of Gynecology and Obstetrics (FIGO) stage retained an independent prognostic value. HPV16, α-9 genera and p16 overexpression were associated with better survival, although not as independent prognostic factors. Patients with p16-negative HPV-associated CC were older, presented with advanced disease and had worse prognosis.     

Second-order shape derivatives along normal trajectories,governed by Hamilton-Jacobi equations

In this paper we introduce a new variant of shape differentiation which is adapted to the deformation of shapes along their normal direction. This is typically the case in the level-set method for shape optimization where the shape evolves with a normal velocity. As all other variants of the original Hadamard method of shape differentiation, our approach yields the same first order derivative. However, the Hessian or second-order derivative is different and somehow simpler since only normal movements are allowed. The applications of this new Hessian formula are twofold. First, it leads to a novel extension method for the normal velocity, used in the Hamilton-Jacobi equation of front propagation. Second, as could be expected, it is at the basis of a Newton optimization algorithm which is conceptually simpler since no tangential displacements have to be considered. Numerical examples are given to illustrate the potentiality of these two applications. The key technical tool for our approach is the method of bicharacteristics for solving Hamilton-Jacobi equations. Our new idea is to differentiate the shape along these bicharacteristics (a system of two ordinary differential equations).     

Fibroblast protein profile analysis highlights the role of oxidative stress and vitamin K recycling in the pathogenesis of pseudoxanthoma elasticum

Pseudoxanthoma elasticum (PXE) is a genetic disorder associated to mutations in the ABCC6 gene; however, the pathogenetic mechanisms leading to elastic fibre calcifications and to clinical manifestations are still unknown. Dermal fibroblasts, directly involved in the production of the extracellular milieu, have been isolated from healthy subjects and from patients affected by PXE, cultured in vitro and characterized for their ability to produce reactive oxygen species, for structural and functional properties of their cell membranes, for changes in their protein profile. Data demonstrate that oxidative stress has profound and endurable consequences on PXE fibroblast phenotype being responsible for: reduced levels of global DNA methylation, increased amount of carbonylated proteins and of lipid peroxidation products, altered structural properties of cell membranes, modified protein expression. Data shed new light on the pathogenetic pathways in PXE, by identifying a network of proteins affecting elastic fibre calcification through inefficient vitamin K recycling, and highlight the role of differentially expressed proteins as targets for validating the efficacy of future therapeutic strategies aiming to delay and/or revert the pathologic phenotype of PXE fibroblasts. Moreover, data open new perspectives for investigating PXE-like phenotypes in the absence of ABCC6 mutations.     

Motion of points and lines in the uncalibrated case

In the present paper we address the problem of computing structure and motion, given a set point and/or line correspondences, in a monocular image sequence, when the camera is not calibrated.Considering point correspondences first, we analyse how to parameterize the retinal correspondences, in function of the chosen geometry: Euclidean, affine or projective geometry. The simplest of these parameterizations is called the FQs-representation and is a composite projective representation. The main result is that considering N+1 views in such a monocular image sequence, the retinal correspondences are parameterized by 11 N–4 parameters in the general projective case. Moreover, 3 other parameters are required to work in the affine case and 5 additional parameters in the Euclidean case. These 8 parameters are calibration parameters and must be calculated considering at least 8 external informations or constraints. The method being constructive, all these representations are made explicit.Then, considering line correspondences, we show how the the same parameterizations can be used when we analyse the motion of lines, in the uncalibrated case. The case of three views is extensively studied and a geometrical interpretation is proposed, introducing the notion of trifocal geometry which generalizes the well known epipolar geometry. It is also discussed how to introduce line correspondences, in a framework based on point correspondences, using the same equations.Finally, considering the F Qs-representation, one implementation is proposed as a motion module, taking retinal correspondences as input, and providing and estimation of the 11 N–4 retinal motion parameters. As discussed in this paper, this module can also estimate the 3D depth of the points up to an affine and projective transformation, defined by the 8 parameters identified in the first section. Experimental results are provided.