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Adverse effects of vitamin D deficiency on the Pi3k/Akt pathway and pancreatic islet morphology in diet‐induced obese mice
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Marcia Marie Maru Marcia Maria Lucchese Cristiano Legnani Welber Gianini Quirino Andrea Balbo Isabele Bulhes Aranha Lílian Terezinha Costa Cecília Vilani Lídia gata de Sena Jailton Carreteiro Damasceno Talita dos Santos Cruz Leandro Reis Lidízio Rui Ferreira e Silva Ado Jorio Carlos Alberto Achete 《Fuel Processing Technology》2009,90(9):1175-1182
Compatibility of the new environmentally-friendly alternative of diesel engine fuels, biodiesel, with storage and engine part materials, is still an open issue. In this work, the interaction between three fuels (petroleum diesel and two types of biodiesel — soybean and sunflower) and two materials (carbon steel and high density polyethylene) used in storage and automotive tanks, is analyzed in detail. A wide set of characterization techniques was used to evaluate the changes in both solid and fluid materials, as weight change measurement, optical, scanning electron and atomic force (AFM) microscopies, Raman and FTIR spectroscopies, and differential scanning calorimetry. The AFM technique allowed detecting surface roughness and morphology changes in the metallic material following the trends in the weight losses. In the case of polymeric material, weight gain by fluid absorption occurred, being detected by the spectroscopic techniques. The biodiesel fuels underwent some ageing however this phenomenon did not affect the interaction between the biodiesel fuels and the substrates. The petrodiesel, which did not age, caused more significant degradation of the substrates. 相似文献
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Bruna Tereza Thomazini Zanella Isabele Cristina Magiore Bruno Oliveira Silva Duran Guilherme Gutierrez Pereira Igor Simes Tiagua Vicente Pedro Luiz Pucci Figueiredo Carvalho Rondinelle Artur Simes Salomo Edson Assuno Mareco Robson Francisco Carvalho Tassiana Gutierrez de Paula Margarida Maria Barros Maeli Dal-Pai-Silva 《International journal of molecular sciences》2021,22(6)
In fish, fasting leads to loss of muscle mass. This condition triggers oxidative stress, and therefore, antioxidants can be an alternative to muscle recovery. We investigated the effects of antioxidant ascorbic acid (AA) on the morphology, antioxidant enzyme activity, and gene expression in the skeletal muscle of pacu (Piaractus mesopotamicus) following fasting, using in vitro and in vivo strategies. Isolated muscle cells of the pacu were subjected to 72 h of nutrient restriction, followed by 24 h of incubation with nutrients or nutrients and AA (200 µM). Fish were fasted for 15 days, followed by 6 h and 15 and 30 days of refeeding with 100, 200, and 400 mg/kg of AA supplementation. AA addition increased cell diameter and the expression of anabolic and cell proliferation genes in vitro. In vivo, 400 mg/kg of AA increased anabolic and proliferative genes expression at 6 h of refeeding, the fiber diameter and the expression of genes related to cell proliferation at 15 days, and the expression of catabolic and oxidative metabolism genes at 30 days. Catalase activity remained low in the higher supplementation group. In conclusion, AA directly affected the isolated muscle cells, and the higher AA supplementation positively influenced muscle growth after fasting. 相似文献
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Liciane Sabadin Bertol Wilson Kindlein Júnior Fabio Pinto da Silva Claus Aumund-Kopp 《Materials & Design》2010
Design and manufacturing of customized implants prior to surgery are described in this study. Implant shape and functional requirements are established by digital data based on CT scans and mirroring operations. The design process of customized mandible prosthesis is illustrated as well as its manufacturing process (direct metal laser sintering) and dimensional control. Laser sintering process and its constraints for the production of customized implants in titanium alloy (Ti–6Al–4V) with complex geometry and internal structures are reported. Important parameters and restrictions in the production of complex parts, including support structures, maximum overhanging angle and internal structure are also described. 相似文献
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Roberta Claro da Silva Ana Paula Badan Ribeiro Fabiana Andreia Schafer De Martini Soares Isabele Renata Capacla Marcia Hazzan Adenilson Oliveira dos Santos Lisandro Pavie Cardoso Luiz Antonio Gioielli 《Journal of the American Oil Chemists' Society》2013,90(5):631-639
Enzymatic interesterification has been shown to be an alternative for the production of structured lipids resembling human milk fat. The knowledge of the physical properties of fat is an important tool for the implementation of this fat in a food matrix. The enzymatic interesterification reaction modifies the composition of triacylglycerols changing the crystallization properties and polymorphic form of fats. Blends containing different proportions of lard and soybean oil (80:20, 70:30, 40:60, 30:70 and 20:80) were enzymatically interesterified in a continuous flow tubular reactor and analyzed for crystalline structure by polarized light microscopy, the polymorphic form using X-ray diffraction and thermal properties by differential scanning calorimetry. The structural modifications resulting from continuous enzymatic interesterification changed the crystallization behavior and thermal profile of the samples, reducing enthalpy values. Structural changes were also evident on polarized light microscopy images, disclosing an increase in the crystallization rate among the samples after the continuous enzymatic reaction. 相似文献
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Joaquim Moroni da Silva Isabele Cristina Bicalho Carlos Henrique Ataíde 《化学工程与技术》2020,43(11):2181-2189
The clogging of hydrocyclones as part of the solids control system in the oil industry is a recurrent operational problem. This occurs mainly due to the agglomeration of fine solids in the underflow duct and also to the incidence of higher-size-range particles than those specified for the equipment. Another common issue that results in poor performance is the formation of an air-core in the low-pressure zone of the separator. In this study, an innovative device coupled to the underflow output of the hydrocyclone was developed in order to minimize these problems. The aim is to mechanically adjust the apex area in a fast and accurate manner, and thus create oscillations in the inlet pressure and flows, constituting a safety system to prevent clogging and air-core formation. 相似文献
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Effect of combined treatment of hydrolysis and polymerization with transglutaminase on β-lactoglobulin antigenicity 总被引:1,自引:0,他引:1
Isabele Serimarco Sabadin Mariana Battaglin Villas-Boas Ricardo de Lima Zollner Flavia Maria Netto 《European Food Research and Technology》2012,235(5):801-809
The effect of combined treatments of hydrolysis with different proteases, and subsequent polymerization with transglutaminase on the antigenic activity of β-Lg was studied. For the hydrolysis of β-Lg using Alcalase, Neutrase or bromelain, the reaction conditions were 3?% β-Lg and enzyme:substrate 25?U?g?1 of protein, as was defined using factorial study. Under these conditions, the degree of hydrolysis (DH) of the hydrolysates was 12.6?% when obtained with Alcalase and approximately 4?% with Neutrase or bromelain. Post-hydrolysis polymerization did not result in an increase in molecular mass of the protein, but these samples presented a lower DH, determined by trinitrobenzenosulfonic acid (TNBS) method, suggesting that polymerization had occurred. Hydrolysis with the three enzymes reduced the β-Lg antigenicity, as evaluated by ELISA and immunoblotting analyses. The IgE-binding responses were practically null (<9?μg?mL?1), 22.82 and 55.73?μg?mL?1 towards the hydrolysates obtained with Alcalase, bromelain, and Neutrase, respectively. The post-hydrolysis polymerization increased or had no significant effect (P?≥?0.05) on the antigenic response of the hydrolysates. 相似文献
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