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排序方式: 共有129条查询结果,搜索用时 15 毫秒
1.
The gravity flow characteristics of pharmaceutically important granules were studied in a cylindrical hopper with attachable orifice disk at the bottom. Results indicate that materials property and orifice diameter play key role in determining mass flow rate while keeping environmental condition (temperature) at fixed range. A new dimensionally analyzed equation was developed to predict gravity flow of pharmaceutically important granules. The developed correlation agreed well with the experimental data. Calcium gluconate and lactose were used for preparing granules. Generally, glidant/lubricant materials are added to pharmaceutical granules during tablet manufacturing process, in order to improve physical property of granular material. Hence, the effect of glidant/lubricant on mass flow of granules through hopper was also studied. Magnesium stearate (1.5%) was added as glidant before granulation. 相似文献
2.
Raheel Hassan Syed Jasmina Pazardzievska Julien Bourgeois 《The Journal of supercomputing》2012,62(2):804-827
Due to the extensive growth of grid computing networks, security is becoming a challenge. Usual solutions are not enough to prevent sophisticated attacks fabricated by multiple users especially when the number of nodes connected to the network is changing over the time. Attackers can use multiple nodes to launch DDoS attacks which generate a large amount of security alerts. On the one hand, this large number of security alerts degrades the overall performance of the network and creates instability in the operation of the security management solutions. On the other hand, they can help in camouflaging other real attacks. To address these issues, a?correlation mechanism is proposed which reduces the security alerts and continue detecting attacks in grid computing networks. To obtain the more accurate results, a?major portion of the experiments are performed by launching DDoS and Brute Force (BF) attacks in real grid environment, i.e., the Grid??5000 (G5K) network. 相似文献
3.
Understanding the influence of demographic and psychological variables on retirement planning. 总被引:1,自引:0,他引:1
The authors examined the degree to which workers were engaging in financial, health, interpersonal/leisure, and work planning for retirement, exploring whether demographic and psychological variables inhibited or promoted planning in each of these domains. Planning in each domain was influenced by a unique set of variables. Goals emerged as a consistent and positive predictor of planning. Gender accounted for health and interpersonal/leisure planning, while work planning behavior was negatively predicted by income. Time perspective also helped to clarify the amount of retirement planning undertaken in the financial and interpersonal/leisure domains. Practical implications for designing retirement interventions are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
4.
Amila Turalić Prof. Jasmina Đeđibegović Dr. Zsófia Hegedüs Prof. Tamás A. Martinek 《Chembiochem : a European journal of chemical biology》2020,21(14):2060-2066
The incorporation of β-amino acids into a peptide sequence has gained particular attention as β- and α/β-peptides have shown remarkable proteolytic stability, even after a single homologation at the scissile bond. Several peptidases have been shown to cleave such bonds with high specificity but at a much slower rate compared to α-peptide bonds. In this study, a series of analogs of dipeptidyl peptidase-4 (DPP-4) substrate inhibitors were synthesized in order to investigate whether β-amino acid homologation at the scissile bond could be a valid approach to improving peptide stability towards DPP-4 degradation. DPP-4 cleaved the α/β-peptide bond after the N-terminal penultimate Pro with a broad specificity and retained full activity regardless of the β3-amino acid side chain and peptide length. Significantly improved half-lives were observed for β3Ile-containing peptides. Replacing the penultimate Pro with a conformationally constrained Pro mimetic led to proteolytic resistance. DPP-4 cleavage of α/β-peptide bonds with a broad promiscuity represents a new insight into the stability of peptide analogs containing β-amino acids as such analogs were thought to be stable towards enzymatic degradation. 相似文献
5.
Yichiet Aun Khaw Yen-Min Jasmina Gan Ming-Lee Ponnusamy Vasaki 《International Journal of Information Security》2022,21(2):161-177
International Journal of Information Security - Context-aware network logging is becoming more prevalent for enterprise networks, data centers, and forensics. Monitoring agents are strategically... 相似文献
6.
Milena Jankovic Ivana Novakovic Dejan Nikolic Jasmina Mitrovic Maksic Slavko Brankovic Ivana Petronic Dragana Cirovic Sinisa Ducic Mirko Grajic Dragana Bogicevic 《International journal of molecular sciences》2021,22(9)
Diabetic neuropathy (DN), the most common chronic and progressive complication of diabetes mellitus (DM), strongly affects patients’ quality of life. DN could be present as peripheral, autonomous or, clinically also relevant, uremic neuropathy. The etiopathogenesis of DN is multifactorial, and genetic components play a role both in its occurrence and clinical course. A number of gene polymorphisms in candidate genes have been assessed as susceptibility factors for DN, and most of them are linked to mechanisms such as reactive oxygen species production, neurovascular impairments and modified protein glycosylation, as well as immunomodulation and inflammation. Different epigenomic mechanisms such as DNA methylation, histone modifications and non-coding RNA action have been studied in DN, which also underline the importance of “metabolic memory” in DN appearance and progression. In this review, we summarize most of the relevant data in the field of genetics and epigenomics of DN, hoping they will become significant for diagnosis, therapy and prevention of DN. 相似文献
7.
Obradovic B Stojkovska J Jovanovic Z Miskovic-Stankovic V 《Journal of materials science. Materials in medicine》2012,23(1):99-107
Alginate colloid solution containing electrochemically synthesized silver nanoparticles (AgNPs) was investigated regarding
the nanoparticle stabilization and possibilities for production of alginate based nanocomposite hydrogels in different forms.
AgNPs were shown to continue to grow in alginate solutions for additional 3 days after the synthesis by aggregative mechanism
and Ostwald ripening. Thereafter, the colloid solution remains stable for 30 days and could be used alone or in mixtures with
aqueous solutions of poly(vinyl alcohol) (PVA) and poly(N-vinyl-2-pyrrolidone) (PVP) while preserving AgNPs as verified by UV–Vis spectroscopy studies. We have optimized techniques
for production of Ag/alginate microbeads and Ag/alginate/PVA beads, which were shown to efficiently release AgNPs decreasing
the Escherichia coli concentration in suspensions for 99.9% over 24 h. Furthermore, Ag/hydrogel discs based on alginate, PVA and PVP were produced
by freezing-thawing technique allowing adjustments of hydrogel composition and mechanical properties as demonstrated in compression
studies performed in a biomimetic bioreactor. 相似文献
8.
Abbass Allan; Arthey Stephen; Elliott Jason; Fedak Tim; Nowoweiski Dion; Markovski Jasmina; Nowoweiski Sarah 《Canadian Metallurgical Quarterly》2011,48(2):109
The advent of readily accessible, inexpensive Web-conferencing applications has opened the door for distance psychotherapy supervision, using video recordings of treated clients. Although relatively new, this method of supervision is advantageous given the ease of use and low cost of various Internet applications. This method allows periodic supervision from point to point around the world, with no travel costs and no long gaps between direct training contacts. Web-conferencing permits face-to-face training so that the learner and supervisor can read each other's emotional responses while reviewing case material. It allows group learning from direct supervision to complement local peer-to-peer learning methods. In this article, we describe the relevant literature on this type of learning method, the practical points in its utilization, its limitations, and its benefits. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
9.
Jasmina Martinovic Ana-Maria Chiorcea-Paquim Juanita Van Wyk Priscilla Baker Ana-Maria Oliveira-Brett 《Electrochimica acta》2008,53(14):4907-4919
The adsorption and the redox processes of two first-generation salicylaldiamine dendritic ligands and their copper, cobalt and nickel metallo-functionalized complexes have been studied at two types of carbon electrode surface. Glassy carbon (GC) was used in an electrochemistry study and highly oriented pyrolitic graphite (HOPG) in ex situ atomic force microscopy (AFM) imaging. All salicylaldimine ligands and their metallo-functionalized complexes adsorb on the surface of the HOPG electrode, resulting in the formation of nanoclusters and films, which vary between 0.9 and 6 nm in size, depending on the metallo-functionalized salicylaldimine dendrimer chemical composition and solution concentration. Differential pulse voltammetry of the surface-confined films has shown that the anodic reactions observed correspond to the oxidation of the hydroxyl groups present in the ligand structure of all compounds. However, by following the changes in peak currents, potentials and width at half height it has been shown that destabilization of the ligand internal structure occurred in the metallo-functionalized complexes depending on the metal involved. The electrochemical behaviour of the surface-confined films observed in buffer solution was related to the morphology, obtained by AFM, of the immobilised first-generation salicylaldiamine dendritic ligands and corresponding salicylaldimine metallo-functionalized complexes. 相似文献
10.
Sandra Kurko Igor MilanovićJasmina Grbović Novaković Nenad IvanovićNikola Novaković 《International Journal of Hydrogen Energy》2014
Desorption of hydrogen atoms from the (110) surface of rutile magnesium hydride (MgH2) was investigated using density functional theory (DFT) and pseudopotential method. System was represented by (110) (2×2) slab MgH2 supercell with 12 atomic layers along the z-axis. The H-desorption was modeled by the successive release of the four two-fold bonded H atoms from the (110) surface of MgH2. Dependence of the H-desorption energy on number and configuration of remaining surface hydrogen atoms has been determined. The features of the H atoms diffusion from the bulk towards the surface have been investigated, too. The results suggest that decrease in number of surface H atoms generally lowers the H-desorption energy in each desorption step and that both the H–H and the Mg–H interatomic interactions strongly influence the H-desorption process. The hydrogen vacancy formation energy in the first three sub-surface layers also exhibits a pronounced dependence on concentration. These findings lead to the conclusion that tendency of the MgH2 (110) surface to preserve a maximum possible surface H concentration in its most stable configuration is the limiting factor for the H-desorption kinetics. In principle, the obtained results allow us to determine preferred paths of surface and sub-surface H-diffusion for a wide range of H concentrations and the principle features of the MgH2 dehydrogenation process, at least for the H-rich region. Being rather comprehensive, the approach is applicable for other metal hydrides, as well. 相似文献