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1.
Jennie O'Loughlin Silvia Napolitano Fahad Alkhathami Cillian O'Beirne Daniel Marhöfer Megan O'Shaughnessy Prof. Orla Howe Prof. Matthias Tacke Dr. Marina Rubini 《Chembiochem : a European journal of chemical biology》2021,22(6):1093-1098
Antibiotic resistance is a growing problem for public health and associated with increasing economic costs and mortality rates. Silver and silver-related compounds have been used for centuries due to their antimicrobial properties. In this work, we show that 1,3-dibenzyl-4,5-diphenyl-imidazol-2-ylidene silver(I) acetate/NHC*-Ag-OAc (SBC3) is a reversible, high affinity inhibitor of E. coli thioredoxin reductase (TrxR; Ki=10.8±1.2 nM). Minimal inhibition concentration (MIC) tests with different E. coli and P. aeruginosa strains demonstrated that SBC3 can efficiently inhibit bacterial cell growth, especially in combination with established antibiotics like gentamicin. Our results show that SBC3 is a promising antibiotic drug candidate targeting bacterial TrxR. 相似文献
2.
Jennie E. Callas 《国际互联网参考资料服务季刊》2013,18(1-2):77-78
SUMMARY Distance learning students may not think of the “campus” library as the first place to fulfill their information needs and may not even be aware of the services available to them. One way to reach these students is to adopt and adapt marketing techniques from the business world. This article examines the findings of a survey conducted at Emporia State University concerning the awareness of distance learning services. It will also examine marketing techniques and illustrate how they can be applied to increase awareness of reference support services for distance learners. 相似文献
3.
Frey Karin S.; Hirschstein Miriam K.; Snell Jennie L.; Edstrom Leihua Van Schoiack; MacKenzie Elizabeth P.; Broderick Carole J. 《Canadian Metallurgical Quarterly》2005,41(3):479
Six schools were randomly assigned to a multilevel bullying intervention or a control condition. Children in Grades 3-6 (N=1,023) completed pre- and posttest surveys of behaviors and beliefs and were rated by teachers. Observers coded playground behavior of a random subsample (n=544). Hierarchical analyses of changes in playground behavior revealed declines in bullying and argumentative behavior among intervention-group children relative to control-group children, increases in agreeable interactions, and a trend toward reduced destructive bystander behavior. Those in the intervention group reported enhanced bystander responsibility, greater perceived adult responsiveness, and less acceptance of bullying/aggression than those in the control group. Self-reported aggression did not differ between the groups. Implications for future research on the development and prevention of bullying are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
4.
5.
Cory D. Boatright Mubbasir Kapadia Jennie M. Shapira Norman I. Badler 《Computer Animation and Virtual Worlds》2015,26(5):483-494
Pedestrian steering algorithms range from completely procedural to entirely data‐driven, but the former grossly generalize across possible human behaviors and suffer computationally, whereas the latter are limited by the burden of ever‐increasing data samples. Our approach seeks the balanced middle ground by deriving a collection of machine‐learned policies based on the behavior of a procedural steering algorithm through the decomposition of the space of possible steering scenarios into steering contexts. The resulting algorithm scales well in the number of contexts, the use of new data sets to create new policies, and in the number of controlled agents as the policies become a simple evaluation of the rules asserted by the machine‐learning process. We also explore the use of synthetic data from an “oracle algorithm” that serves as an as‐needed source of samples, which can be stochastically polled for effective coverage. We observe that our approach produces pedestrian steering similar to that of the oracle steering algorithm, but with a significant performance boost. Runtime was reduced from hours under the oracle algorithm with 10 agents to on the order of 10 frames per second (FPS) with 3000 agents. We also analyze the nature of collisions in such a framework with no explicit collision avoidance. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
6.
爱立信IMS weShare业务有20%的开发与用户视觉体验相关(用户界面、图标、标签以及进度条),其它的80%则主要致力于设备间的系统.与此相对比,用户的体验则完全(100%)有赖于其可接触的事物. 相似文献
7.
Reports an error in Treatment presentation and adherence of Iraq/Afghanistan era veterans in outpatient care for posttraumatic stress disorder by Christopher R. Erbes, Kyle T. Curry and Jennie Leskela (Psychological Services, 2009[Aug], Vol 6[3], 175-183). The copyright for the article was listed incorrectly. This article is in the Public Domain. The online version has been corrected. (The following abstract of the original article appeared in record 2009-12007-001.) The ongoing wars in Afghanistan (Operation Enduring Freedom or OEF) and Iraq (Operation Iraqi Freedom or OIF) make the development and application of effective postdeployment mental health treatment programs a high priority. There has been some concern that existing treatment programs for combat-related posttraumatic stress disorder (PTSD) may not fit well with OEF/OIF veterans confronted with acute mental health difficulties while reestablishing community, familial, and occupational connections after their deployment. This study utilized data gathered from a large outpatient Veterans Affairs Medical Center PTSD treatment clinic to examine differences in initial treatment presentation and treatment adherence (attendance and dropout) between a group of Vietnam era veterans (n = 54) and a group of OEF/OIF veterans (n = 106). OEF/OIF veterans reported lower levels of symptom distress on questionnaires assessing posttraumatic reexperiencing, avoidance, dissociation, and arousal symptoms but similar levels of anger and acting out behaviors and higher levels of alcohol problems. OEF/OIF veterans had significantly lower rates of session attendance and higher rates of treatment dropout than Vietnam veterans, and this difference was not accounted for by differences in treatment presentation. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
8.
Jing Hu Jennie Si Byron P Olson Jiping He 《IEEE transactions on neural systems and rehabilitation engineering》2005,13(3):256-262
Principal component analysis was performed on recorded neural spike trains in rats' motor cortices when rats were involved in real-time control tasks using brain-machine interfaces. The rat with implanted microelectrode array was placed in a conditioning chamber, but freely moving, to decide which one of the two paddles should be activated to shift the cue light to the center. It is found that the principal component feature vectors revealed the importance of individual neurons and windows of time in the decision making process. In addition, one of the first principal components has much higher discriminative capability than others, although it represents only a small percentage of the total variance in the data. Using one to six principal components with a Bayes classifier achieved classification accuracy comparable to that obtained by a more sophisticated high performance support vector classifier. 相似文献
9.
Spatial analysis of annual air pollution exposure and mortality 总被引:1,自引:0,他引:1
Scoggins A Kjellstrom T Fisher G Connor J Gimson N 《The Science of the total environment》2004,321(1-3):71-85
The aim of this study was to relate ambient air pollution levels to mortality in Auckland, New Zealand. We used urban airshed modelling and GIS-based techniques to quantify long-term exposure to ambient air pollution levels and associated mortality. After adjusting for age, sex, ethnicity, socio-economic status, and urban/rural domicile there was a 1.3% (95%CI: 1-1.5%) increase in non-external cause mortality, and 1.8% (95%CI: 1.5-2.1%) increase in circulatory and respiratory causes per 1 microg/m(3) increase in annual average NO(2). Based on these exposure-response relationships and applying an annual average threshold of 13 microg/m(3), the average annual (for 1996-1999) number of people estimated to die from non-external causes and circulatory and respiratory causes attributable to air pollution in Auckland is 268 (95% range: 227-310) (3.9% of total all cause deaths) and 203 (95% range: 169-237) (5.9% of total circulatory and respiratory deaths) per year, respectively. The number of attributable deaths found in this study are consistent with a previous New Zealand risk assessment using a different methodology, and is approximately twice the number of people dying from motor vehicle accidents in the region, which is on average (1996-1999) 103 per year. The GIS-based exposure maps identify high exposure areas for policy developers and planners in a simple and realistic manner. Taken together with overseas studies the study provides additional evidence that long-term exposure to poor air quality, even at levels below current standards, is a hazard to the public health. 相似文献
10.
Proteomic tools for quantitation by mass spectrometry 总被引:6,自引:0,他引:6
Lill J 《Mass spectrometry reviews》2003,22(3):182-194
Techniques for the quantitation of proteins and peptides by mass spectrometry (MS) are reviewed. A range of labeling processes is discussed, including metabolic, enzymatic, and chemical labeling, and techniques that can be employed for comparative and absolute quantitation are presented. Advantages and drawbacks of the techniques are discussed, and suggestions for the appropriate uses of the methodologies are explained. Overall, the metabolic incorporation of isotopic labels provides the most accurate labeling strategy, and is most useful when an internal standard for comparative quantitation is needed. However, that technique is limited to research that uses cultured cells. 相似文献