Thoracic and abdominal SPECT-CT image fusion without external markers in endocrine carcinomas. The Group of Thyroid Tumoral Pathology of Champagne-Ardenne

Superimposition of SPECT and computed tomography (CT) slices from the thoracoabdominal region was achieved without the use of external markers for 14 studies in 13 patients with endocrine carcinoma. Technical feasibility and clinical validation of this retrospective fusion method were assessed. METHODS: Patients had a history of thyroid cancer or of carcinoid tumor. To detect tumor sites, CT scan and dual-isotope tomoscintigraphy were performed, with 99mTc-hydroxymethylene diphosphonate for bone scintigraphy and with 111In-pentetreotide, 131I or 131I-metaiodobenzylguanidine for tumor scintigraphy (TS). A superimposition method previously developed for the pelvic region was adapted to the nonrigid thoraco-abdominal region. CT-bone scintigraphy and CT-TS superimposed images were obtained. Clinical validation of the information obtained from the superimposed images was obtained from surgery or follow-up imaging studies performed after clinical evolution of the disease process. RESULTS: Reliable and reproducible registration was achieved in all patients. CT-TS superimposed images produced accurate localization of abnormal TS foci. Accuracy was limited primarily by variable relative displacements of the thoracoabdominal organs. For 10 sites in 8 patients, localization and/or characterization obtained from CT-TS images was confirmed by a reference technique. Superimposition enabled the localization of tumor sites that otherwise could not have been suspected from CT alone and allowed the characterization of CT suspicious masses and the confirmation of CT positive sites. Nonspecific tumor TS uptake sites were also localized. CONCLUSION: With standard CT and dual-isotope SPECT acquisitions, SPECT-CT fusion is feasible in the thoracoabdominal region without the use of external markers. Fused images were validated in 8 patients for 10 sites. The use of this technique could probably improve the management and care of patients with endocrine carcinoma.     

Transient and dynamic average-value modeling of synchronous machinefed load-commutated converters

A new average-value model of a synchronous machine fed load-commutated converter is set forth in which the stator dynamics are combined with the DC link dynamics. This model is shown to he extremely accurate in predicting system transients and in predicting frequency-domain characteristics such as the impedance looking into the synchronous machine fed load-commutated converter. The model is verified against a detailed computer simulation and against a hardware test system, thus providing a three-way comparison. The proposed model is shown to be much more accurate than models in which the stator dynamics are neglected     

L'observation des processus de groupe: difficultés méthodologiques et perspectives.

Discusses problems involved in collecting data based on observation of small groups. The example of a study of manifestations of cooperation in groups of preschoolers (aged 21–57 mo) is used for illustration. Statistical treatment of observation data and global analysis of data are considered. (English abstract) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Ka-band solid-state pulsed Gunn oscillator and power combiner

GaAs Gunn diodes were fabricated for pulse source application at 8 mm wave band and operated with pulsewidths of 0.05 to 2.0 microseconds and duty cycles of 0.001 to 0.01. Peak pulse output power levels of 0.8–1.2W are achieved and the maximum available power is 1.6W with the highest efficiency of 6.5 percent. A simple and compact pulsed power combiner is also given in this paper.     

Routing and resource optimization in service overlay networks

Service Overlay Networks (SONs) create a virtual topology on top of the Internet and provide end-to-end quality of service guarantees without requiring support by the underlying network.The optimization of the resources utilized by an SON is a fundamental issue for an overlay operator owing to the costs involved and the need to satisfy user requirements. Careful decisions are necessary to provide enough capacity to overlay links, to route traffic, to assign users to access nodes and to deploy overlay nodes.In this paper, we propose two mathematical programming models for the user assignment problem, the traffic routing optimization and the dimensioning of the capacity reserved on overlay links in SONs. The first model minimizes the SON installation cost while providing full access to all users. The second model maximizes the SON profit by selecting which users to serve, based on the expected gain, and taking into consideration budget constraints of the SON operator. Moreover, we extend these models to include the optimization of the number and position of overlay nodes.We provide the optimal solutions of the proposed SON design formulations on a set of realistic-size instances and discuss the effect of different parameters on the characteristics of the planned networks. Numerical results show that the proposed approach is able to solve the problem to the optimum even for large-scale networks.     

Seipin Deficiency as a Model of Severe Adipocyte Dysfunction: Lessons from Rodent Models and Teaching for Human Disease

Obesity prevalence is increasing worldwide, leading to cardiometabolic morbidities. Adipocyte dysfunction, impairing white adipose tissue (WAT) expandability and metabolic flexibility, is central in the development of obesity-related metabolic complications. Rare syndromes of lipodystrophy characterized by an extreme paucity of functional adipose tissue should be considered as primary adipocyte dysfunction diseases. Berardinelli-Seip congenital lipodystrophy (BSCL) is the most severe form with a near absence of WAT associated with cardiometabolic complications such as insulin resistance, liver steatosis, dyslipidemia, and cardiomyopathy. Twenty years ago, mutations in the BSCL2 gene have been identified as the cause of BSCL in human. BSCL2 encodes seipin, an endoplasmic reticulum (ER) anchored protein whose function was unknown back then. Studies of seipin knockout mice or rats demonstrated how seipin deficiency leads to severe lipodystrophy and to cardiometabolic complications. At the cellular levels, seipin is organized in multimers that are particularly enriched at ER/lipid droplet and ER/mitochondria contact sites. Seipin deficiency impairs both adipocyte differentiation and mature adipocyte maintenance. Experiments using adipose tissue transplantation in seipin knockout mice and tissue-specific deletion of seipin have provided a large body of evidence that liver steatosis, cardiomyopathy, and renal injury, classical diabetic complications, are all consequences of lipodystrophy. Rare adipocyte dysfunctions such as in BSCL are the key paradigm to unravel the pathways that control adipocyte homeostasis. The knowledge gathered through the study of these pathologies may bring new strategies to maintain and improve adipose tissue expandability.     

A guide to data communications: B-ISDN and how it works

The capabilities of the emerging broadband integrated services digital network (B-ISDN) are examined. Fundamental differences between broadband and narrowband ISDN are identified. The basics of asynchronous transfer mode (ATM), the switching technique used by BISDN networks, are discussed. Channel identification, generic flow control, using ATM, and connectionless service are considered. The first services expected to make use of ATM are briefly described     

Study of the Action of Static and Dynamic Fusimotor Fibers With a Mechanical Model of the Mammalian Muscle Spindle

A model of the mammalian muscle spindle having three distinct parts is proposed. The three parts, which consist of a mechanical filter, a transducer, and an encoder, are closely related with their physiological counterparts. A study of the generator potentials for the primary and secondary endings of the spindle was performed by means of an analog computer simulation of the model. The afferent responses of the spindle under a phasic stretch with and without fusimotor fibers simulation are also studied. Finally, frequencygrams (see text) are obtained under the condition of ?1 (dynamic) stimulation acting on both nuclear bag and nuclear chain fibers. The model yields results that are directly comparable with physiological data obtained under similar conditions.     

Parallel Ant Colony Optimization on Graphics Processing Units

The purpose of this paper is to propose effective parallelization strategies for the Ant Colony Optimization (ACO) metaheuristic on Graphics Processing Units (GPUs). The Max–Min Ant System (MMAS) algorithm augmented with 3-opt local search is used as a framework for the implementation of the parallel ants and multiple ant colonies general parallelization approaches. The four resulting GPU algorithms are extensively evaluated and compared on both speedup and solution quality on a state-of-the-art Fermi GPU architecture. A rigorous effort is made to keep parallel algorithms true to the original MMAS applied to the Traveling Salesman Problem. We report speedups of up to 23.60 with solution quality similar to the original sequential implementation. With the intent of providing a parallelization framework for ACO on GPUs, a comparative experimental study highlights the performance impact of ACO parameters, GPU technical configuration, memory structures and parallelization granularity.