Computation of nonlinear functionals in particle methods

We consider the numerical computation of nonlinear functionals of distribution functions approximated by point measures. Two methods are described and estimates for the speed of convergence as the number of points tends to infinity are given. Moreover, numerical results for the entropy functional are presented.     

Meshfree method for fluctuating hydrodynamics

In the current study a meshfree Lagrangian particle method for the Landau–Lifshitz Navier–Stokes (LLNS) equations is developed. The LLNS equations incorporate thermal fluctuation into macroscopic hydrodynamics by the addition of white noise fluxes whose magnitudes are set by a fluctuation–dissipation theorem. The study focuses on capturing the correct variance and correlations computed at equilibrium flows, which are compared with available theoretical values. Moreover, a numerical test for the random walk of standing shock wave has been considered for capturing the shock location.     

Schrifttumsberichte

Ohne Zusammenfassung     

Schrifttumsberichte

Ohne Zusammenfassung     

Chemie,Holz als Energiequelle

Ohne Zusammenfassung     

A Technology Readiness Level scale for iron and steel industries

The Technology Readiness Level (TRL) scale is one of the most popular maturity assessment techniques used by industrial firms worldwide. However, it is not a panacea that will work for every firm or every industry in its original form. Consequently, for the scale to be truly useful, it has to be adapted to fit the unique features of different firms and industries. In this article, we propose a revised and domain-specific TRL scale for evaluating technology maturity in iron and steel industries. This revised scale takes into account the idiosyncrasies of such firms, for example, product/process interdependencies, scaling problems, the reliance on pilot and demonstration experiments, and the fact that input and output materials are ingredients rather than components. The revised TRL scale helps managers to assess technology maturity and reduce risk by delivering better project and technology evaluations and providing a ‘common language’.     

Rational approach for the analysis of segmental reinforced soil walls based on kinematic constraints

The paper presents an analytical method for the solution of reinforced soil walls in which the wall facing has a structural role. The three-component (soil–reinforcement–wall) system is statically indeterminate, and hence cannot be solved by equilibrium equations alone. The paper follows up on the work of Baker and Klein [2004. An integrated limiting equilibrium approach for design of reinforced soil retaining structures part I – formulation. Geotextiles and Geomembranes 22, 119–150] where an interaction model, incorporating factors that divide forces between the reinforcement layers and the wall, was introduced to solve the statically indeterminate system. In the current work, the division factors are resolved such that the kinematic constraints of compatibility between the reinforcement layers and the wall are satisfied. This is achieved by solving an optimization problem in which the objective function includes the relative displacement between the reinforcement layers and the wall. The resultant system is fully coupled whereby upper reinforcement layers are affected by the behavior of lower layers. As such, the method overcomes the limitation of the original framework in which the top-down procedure omits such coupling. A non-dimensional parametric study was conducted on walls with 10 face blocks (9 reinforcement layers). Results are given in a normalized manner for cases in which the reinforcement pullout stiffness is uniform and linearly increasing with depth. Analysis results show that in cases where the wall is relatively stiff compared to the reinforcement, the upper reinforcement layers are clearly affected by the lower layers (this is a direct outcome of the fully coupled system). On the other hand, when the relative stiffness of the wall is low, the system behavior tends towards that of a hinged system, which is statically determinate. In this case the solution becomes independent of the reinforcement pullout stiffness. Analysis results indicate that current design codes, which do not explicitly consider the structural role of the facing in the calculation procedure, may be overconservative in certain cases. This result supports the argument for introducing the structural role of the facing into design procedures.     

Polyplexes of polyethylenimine and per-N-methylated polyethylenimine-cytotoxicity and transfection efficiency

For non-viral gene delivery, the carriers for DNA transfer into cells must be vastly improved. The branched cationic polymer polyethylenimine has been described as an efficient gene carrier. However, polyethylenimine was demonstrated to mediate substantial cytotoxicity. Therefore, this study is aimed at investigating per-N-methylated polyethylenimine, which is thought to have a much lower cytotoxicity due to its lower charge density. Results from a gel retardation assay and laser light scattering indicated that per-N-methylated polyethylenimine condenses DNA into small and compact nanoparticles with a mean diameter <150 nm. Furthermore, polyplexes of polyethylenimine and per-N-methylated polyethylenimine with DNA had a positive zeta potential and the polymers protected DNA from nuclease-mediated digestion. The transfection efficiency of polyethylenimine and per-N-methylated polyethylenimine was tested in CHO-K1 cells. Using green fluorescent protein as reporter gene and flow cytometry analysis, we demonstrated that per-N-methylated polyethylenimine has a lower cytotoxicity, but also a significantly lower transfection efficiency. Using propidium iodide staining, we could additionally distinguish between viable and dead cells. At NP > or = 12, per-N-methylated polyethylenimine showed a much higher cell viability and the ratio of viable and transfected cells to dead and transfected cells was about 1.5 to 1.7 fold higher than for polyethylenimine. The results of cell viability from flow cytometry analysis were confirmed by the MTS assay. Using luciferase reporter gene for transfection experiments, the gene expression of per-N-methylated polyethylenimine was lower at NP 6, 12 and 18 as compared to polyethylenimine, but at NP 24 it yielded similar levels.     

Analysis of dichotomous outcome data for community intervention studies

Community intervention trials are becoming increasingly popular as a tool for evaluating the effectiveness of health education and intervention strategies. Typically, units such as households, schools, towns, counties, are randomized to receive either intervention or control, then outcomes are measured on individuals within each of the units of randomization. It is well recognized that the design and analysis of such studies must account for the clustering of subjects within the units of randomization. Furthermore, there are usually both subject level and cluster level covariates that must be considered in the modelling process. While suitable methods are available for continuous outcomes, data analysis is more complicated when dichotomous outcomes are measured on each subject. This paper will compare and contrast several of the available methods that can be applied in such settings, including random effects models, generalized estimating equations and methods based on the calculation of 'design effects', as implemented in the computer package SUDAAN. For completeness, the paper will also compare these methods of analysis with more simplistic approaches based on the summary statistics. All the methods will be applied to a case study based on an adolescent anti-smoking intervention in Australia. The paper concludes with some general discussion and recommendations for routine design and analysis.     

Structure and electrical conductivity of TCNQ-2,3,7,8-tetramethoxychalcogenanthrene complexes

Charge-transfer complexes formed by reaction of 2,3,7,8-tetramethoxychalcogenanthrenes(5,10-dichalcogenacyclo-diveratrylenes, ‘Vn₂E₂’) with 7,7,8,8-tetracyanoquinodimethane (TCNQ) are prepared and their structures determined. Spin concentration, mobilities and gap energies of the polycrystalline samples are evaluated from e.s.r. intensities and electrical conductivity measurements. The influence of the different chalcogen atoms on physical properties is discussed.