Pharmacodynamic Comparison of a Nasal Formulation of Verapamil and Intravenous and Oral Dosage Forms

The nasal route has been shown to be effective for the administration of numerous drugs in order to improve drug bioavailability. A nasal gel of verapamil hydrochloride was formulated and evaluated pharmacodynamically in humans, using electrocardiographic results, with comparison to oral and IV routes. Seven volunteers were involved in the study and the pharmacodynamic parameters were evaluated statistically. Experimental nasal gel showed similar pharmacodynamic results with the intravenous route, which is a hint to the reduction in verapamilinduced first-pass metabolism. However, oral route of administration showed a tendency of less efficacy. No reasonable effect of verapamil could be obtained with the placebo group.     

Cost effective second generation AC-modules: Development and testing aspects

In the framework of the European research project PV2GO, a new AC-module inverter was developed, taking into account all relevant aspects from a European market's point of view (standards, market, application, and research and development goals). The project goal was to achieve the overall system costs of 3 Euro per Wp for a modular plug-and-play photovoltaic system. For the photovoltaic-module, a standard 130-Wp Eurosolare module was chosen. The research and development (R&D) goal was to develop an advanced DC-control system consisting of a state-of-the-art programmable digital device and an Application Specific Integrated Circuit (ASIC) for the AC-control of the inverter. According to the topology concept, thermal and magnetic designs were optimized with regard to production technology and packaging for large-scale production. The new AC-modules were tested in a number of field-test sites in various parts of Europe and their reliability was assessed through Highly Accelerated Stress Tests. Efficiency and power quality have been tested in the laboratory. Further in the PV2GO project an optimization study of the manufacturing process of the new generation of AC-modules for high volume output was done. Another task was the pre-certification procedure to assure compliance with the European guidelines and standards.     

Design and analysis of a social botnet

Online Social Networks (OSNs) have attracted millions of active users and have become an integral part of today’s web ecosystem. Unfortunately, in the wrong hands, OSNs can be used to harvest private user data, distribute malware, control botnets, perform surveillance, spread misinformation, and even influence algorithmic trading. Usually, an adversary starts off by running an infiltration campaign using hijacked or adversary-owned OSN accounts, with an objective to connect with a large number of users in the targeted OSN. In this article, we evaluate how vulnerable OSNs are to a large-scale infiltration campaign run by socialbots: bots that control OSN accounts and mimic the actions of real users. We adopted the design of a traditional web-based botnet and built a prototype of a Socialbot Network (SbN): a group of coordinated programmable socialbots. We operated our prototype on Facebook for 8 weeks, and collected data about user behavior in response to a large-scale infiltration campaign. Our results show that (1) by exploiting known social behaviors of users, OSNs such as Facebook can be infiltrated with a success rate of up to 80%, (2) subject to user profile privacy settings, a successful infiltration can result in privacy breaches where even more private user data are exposed, (3) given the economics of today’s underground markets, running a large-scale infiltration campaign might be profitable but is still not particularly attractive as a sustainable and independent business, (4) the security of socially-aware systems that use or integrate OSN platforms can be at risk, given the infiltration capability of an adversary in OSNs, and (5) defending against malicious socialbots raises a set of challenges that relate to web automation, online-offline identity binding, and usable security.     

A similarity coefficient measure and machine-parts grouping in cellular manufacturing systems

For more than three decades, similarity coefficient measures one of the important tools for solving group technology problems have gained the attention of the research community in cellular manufacturing systems. A new similarity coefficient measure that uses a set of important characteristic properties for grouping is developed here for use as an intermediate tool to form cohesive cells. A mathematical model that uses this similarity coefficient for optimally solving the cell-formation problems in cellular manufacturing is developed. A heuristic procedure that improves the optimal methodology in term of solution capability of the large instances is devised for an efficient solution. Both the optimal methodology and the heuristic are applied to some well-known problems from literature to compare the grouping efficiencies. The similarity coefficient and the solution methodologies developed are able to solve the cell formation problems efficiently.     

Experimental study on conventional solar still integrated with inclined solar still under different water depth

This study primarily focuses on comparative experimental analysis on standalone conventional solar still (CSS), inclined solar still (ISS), and integrated conventional and inclined solar still (CSS‐ISS) for different parameters that affect the freshwater yield. For enhancing the freshwater yield only a few studies are available on still‐still integration. The present novel study provides a greater improvement in improving the freshwater yield by integrating ISS with CSS. This experimental work mainly concentrates on the importance of water depth (d _w) and mass flow rate of water ( m _w) in the solar still. Water depth inside the conventional still varied from 0.02 to 0.06 m whereas, water is constantly flown with a mass flow rate of 8.33 kg/hour in an ISS with baffles. The experimental result shows that the accumulated freshwater yield from CSS‐ISS, ISS, and CSS were 6.2, 5.04, and 4.24 kg, respectively. CSS‐ISS and ISS produced 46.23% and 18.87% higher productivity than the CSS. From the experimental investigation, it is also identified that the water temperature is significantly improved by 20% using integration as compared with CSS without integration under the same water depth of d _w = 0.02 m. The overall improvement in yield was higher in the case of CSS‐ISS. The deviations between experimental and theoretical values of yield from the conventional and modified solar still were in the range of ±7%.     

XPloreRank: exploring XML data via you may also like queries

World Wide Web - In many cases, users are not familiar with their exact information needs while searching complicated data sources. This lack of understanding may cause the users to feel...     

Optimum structural modelling for tall buildings

It is a common practice to model multi‐storey tall buildings as frame structures where the loads for structural design are supported by beams and columns. Intrinsically, the structural strength provided by the walls and slabs are neglected. As the building height increases, the effect of lateral loads on multi‐storey structures increases considerably. The consideration of walls and slabs in addition to the frame structure modelling shall theoretically lead to improved lateral stiffness. Thus, a more economic structural design of multi‐storey buildings can be achieved. In this research, modelling and structural analysis of a 61‐storey building have been performed to investigate the effect of considering the walls, slabs and wall openings in addition to frame structure modelling. Sophisticated finite element approach has been adopted to configure the models, and various analyses have been performed. Parameters, such as maximum roof displacement and natural frequencies, are chosen to evaluate the structural performance. It has been observed that the consideration of slabs alone with the frame modelling may have negligible improvement on structural performance. However, when the slabs are combined with walls in addition to frame modelling, significant improvement in structural performance can be achieved. Copyright © 2012 John Wiley & Sons, Ltd.