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1.
Self-assembly is the process by which objects aggregate independently and form complex structures. One of the theoretical
frameworks in which the process of self-assembly can be embedded and formally studied is that of tile systems. A Wang tile
is a square unit, with glues on its edges, attaching to other tiles which have matching glues, and forming larger and larger
structures. In this paper we concentrate over two basic, but essential, self-assembling structures done by Wang tiles. The
first one, called ribbon, is a non-self-crossing wire-like structure, in which successive tiles are adjacent along an edge,
and where tiles are glued to their predecessor and successor by use of matching glues. The second one, called zipper, is a
similar contiguous structure, only that here, all touching tiles must have matching glues on their abutting edges, independently
of their position in the structure. In case of Wang tiles, it has been shown that these two structures are equivalent. Here
we generalize this result for the case when the tiles have eight glues, four on their edges and four on their corners. Thus
we show that an eight neighborhood dependency, namely the Moore neighborhood, can be simulated by a quasi-linear dependency. 相似文献
2.
Lila Kari Kalpana Mahalingam Shinnosuke Seki 《Theoretical computer science》2009,410(24-25):2393-2400
3.
This paper provides a bridge between the classical tiling theory and the complex-neighborhood self-assembling situations that exist in practice.The neighborhood of a position in the plane is the set of coordinates which are considered adjacent to it. This includes classical neighborhoods of size four, as well as arbitrarily complex neighborhoods. A generalized tile system consists of a set of tiles, a neighborhood, and a relation which dictates which are the “admissible” neighboring tiles of a given tile. Thus, in correctly formed assemblies, tiles are assigned positions of the plane in accordance with this relation.We prove that any validly tiled path defined in a given but arbitrary neighborhood (a zipper) can be simulated by a simple “ribbon” of microtiles. A ribbon is a special kind of polyomino, consisting of a non-self-crossing sequence of tiles on the plane, in which successive tiles stick along their adjacent edge.Finally, we extend this construction to the case of traditional tilings, proving that we can simulate arbitrary-neighborhood tilings by simple-neighborhood tilings, while preserving some of their essential properties. 相似文献
4.
Data are considered to be important organizational assets because of their assumed value, including their potential to improve
the organizational decision-making processes. Such potential value, however, comes with various costs, including those of
acquiring, storing, securing and maintaining the given assets at appropriate quality levels. Clearly, if these costs outweigh
the value that results from using the data, it would be counterproductive to acquire, store, secure and maintain the data.
Thus cost–benefit assessment is particularly important in data warehouse (DW) development; yet very few techniques are available
for determining the value that the organization will derive from storing a particular data table and hence determining which
data set should be loaded in the DW. This research seeks to address the issue of identifying the set of data with the potential
for producing the greatest net value for the organization by offering a model that can be used to perform a cost–benefit analysis
on the decision support views that the warehouse can support and by providing techniques for estimating the parameters necessary
for this model. 相似文献
5.
Lila RaoAuthor Vitae Kweku-Muata Osei-BrysonAuthor Vitae 《Decision Support Systems》2012,52(3):577-589
Business Process Re-engineering (BPR) is being used to improve the efficiency of the organizational processes, however, a number of obstacles have prevented its full potential from being realised. One of these obstacles is caused by an emphasis on the business process itself at the exclusion of considering other important knowledge of the organization. Another is due to the lack of tools for identifying the cause of the inefficiencies and inconsistencies in BPR. In this paper we propose a methodology for BPR that overcomes these two obstacles through the use of a formal organizational ontology and knowledge structure and source maps. These knowledge maps are represented formally to facilitate an inferencing mechanism which helps to automatically identify the causes of the inefficiencies and inconsistencies. We demonstrate the applicability of this methodology through the use of a case study of a university domain. 相似文献
6.
Aleksey Prizov Elena Tchetina Ilya Eremin Nikolay Zagorodniy Andrey Pulin Evgeniy Belyak Evgeniy Goncharov Konstantin Kotenko Ivan Smyshlyaev Svetlana Glukhova Aleksandr Lila 《International journal of molecular sciences》2022,23(21)
Functional outcomes and synovial fluid (SF) cytokine concentrations in response to platelet-rich plasma (PRP) or stromal vascular fraction (SVF) post-treatments following open wedge high tibial osteotomy (HTO) in 20 patients with knee osteoarthritis (OA) were examined. Six weeks after surgery, the knees of 10 patients were injected with autologous PRP (PRP subgroup), while another 10 patients were injected with autologous SVF (SVF subgroup) and monitored for 1.5 years. Pain assessment (VAS score) and functional activity (KOOS, KSS, Outerbridge, and Koshino scores) were applied. PRP subgroup performed better compared with the SVF subgroup according to KOOS, KSS, and VAS scores, while the SVF subgroup demonstrated better results according to Outerbridge and Koshino testing and produced more pronounced cartilage regeneration in the medial condyle and slowed down cartilage destruction in its lateral counterpart. SF was collected before and one week after PRP or SVF injections and tested for concentrations of 41 cytokines (Multiplex Assay). In the PRP subgroup, a significant decrease in IL-6 and CXCL10 synovial concentrations was accompanied by an increase in IL-15, sCD40L, and PDGF-AB/BB amounts. The SVF subgroup demonstrated a significant decrease in synovial TNFα, FLT-3L, MIP-1β, RANTES, and VEGF concentrations while SF concentrations of MCP-1 and FGF2 increased. Both post-treatments have a potential for increased tissue regeneration, presumably due to the downregulation of inflammation and augmentation of synovial growth factor concentrations. 相似文献
7.
Yew Joon Tam Morvarid Akhavan Rezaei Mohd Lila Mohd Azmi Abdul Rani Bahaman Sewn Cen Lo 《分离科学与技术》2016,51(5):816-829
Univariate screening on factors affecting the purification performance of recombinant hepatitis B surface antigen (HBsAg) on ion exchange chromatography (IEC) and size exclusion chromatography (SEC) and the establishment of a two-step purification strategy were performed. Amongst four IEC adsorbents examined, the use of Q Sepharose XL IEC adsorbent under optimized conditions together with optimized SEC purification was able to efficiently purify HBsAg. An established purification strategy comprising the two techniques further demonstrated adaptability for scale-up operations with a final total purification factor (PF) of 94.82 ± 16.20, HBsAg purity of 95.48% and recovery yield of 78.07%. 相似文献
8.
Effect of sarsaponin on ruminal fermentation with particular reference to methane production in vitro 总被引:6,自引:0,他引:6
This experiment was designed to investigate the effects of different concentrations (0, 1.2, 1.8, 2.4, and 3.2 g/L) of sarsaponin on ruminal microbial methane production using the substrates soluble potato starch, cornstarch, or hay plus concentrate (1.5:1). Ruminal fluid was collected from a dairy cow, mixed with phosphate buffer (1:2) and incubated (30 ml) anaerobically at 38 degrees C for 6 and 24 h with or without sarsaponin. Excluding the lower level of sarsaponin, pH of the medium was slightly decreased. Ammonia-N concentration and numbers of protozoa were decreased in a dose-dependent manner. Total volatile fatty acids and total gas production were increased. Molar proportion of acetate was decreased and propionate was increased with a corresponding decrease in acetate:propionate ratio. Hydrogen production was decreased. As the concentration of sarsaponin increased from 1.2 to 3.2 g/L, fermentation of soluble potato starch, cornstarch, or hay plus concentrate decreased methane production from 20 to 60% (6 h) and 17 to 50% (24 h), 21 to 58% (6 h) and 18 to 52% (24 h), and 23 to 53% (6 h) and 15 to 44% (24 h), respectively. Excluding the lower dose concentration (1.2 g/L) of sarsaponin, in vitro disappearance of dry matter of hay plus concentrate was decreased after 24 h. In conclusion, these results show that sarsaponin stimulated the mixed ruminal microorganism fermentation as well as to inhibit methane production in vitro. 相似文献
9.
Yifeng Lei Omar F. Zouani Lila Rami Christel Chanseau Marie‐Christine Durrieu 《Small (Weinheim an der Bergstrasse, Germany)》2013,9(7):1086-1095
How endothelial cells (ECs) express the particular filopodial or lamellipodial form of the actin machinery is critical to understanding EC functions such as angiogenesis and sprouting. It is not known how these mechanisms coordinately promote lumen formation of ECs. Here, adhesion molecules (RGD peptides) and inductor molecules (BMP‐2 mimetic peptides) are micropatterned onto polymer surfaces by a photolithographic technique to induce filopodial and lamellipodial migration modes. Firstly, the effects of peptide microgeometrical distribution on EC adhesion, orientation and morphogenesis are evaluated. Large micropatterns (100 μm) promote EC orientation without lumen formation, whereas small micropatterns (10–50 μm) elicit a collective cell organization and induce EC lumen formation, in the case of RGD peptides. Secondly, the correlation between EC actin machinery expression and EC self‐assembly into lumen formation is addressed. Only the filopodial migration mode (mimicked by RGD) but not lamellipodial migration mode (mimicked by BMP‐2) promotes EC lumen formation. This work gives a new concept for the design of biomaterials for tissue engineering and may provide new insight for angiogenesis inhibition on tumors. 相似文献
10.
Barnes S Prasain J D'Alessandro T Arabshahi A Botting N Lila MA Jackson G Janle EM Weaver CM 《Food & function》2011,2(5):235-244
Polyphenols in dietary and botanical matrices are usually present as simple and complex O-glycosides. In fermented dietary materials, the glycosidic moiety is removed and accompanied in some cases by more complex changes to the polyphenol. As for most xenobiotics, polyphenols undergo phase II conjugation in the intestinal wall during their absorption from the gut. In contrast, a few polyphenols, such as puerarin in the kudzu vine, are C-glycosides and are stable in the gut and during absorption, distribution and excretion. Large bowel bacteria reduce polyphenol aglycones, causing opening of the heterocyclic B-ring and ring cleavage. The products are mostly absorbed and enter the bloodstream. Phase I and II metabolism events occur in the intestine and the liver - most polyphenols predominantly circulate as β-glucuronides and sulfate esters with very little as the aglycones, the presumed active forms. In addition, metabolism can occur in non-hepatic tissues and cells including breast tumor cells that have variable amounts of cytochrome P450s, sulfatase and sulfotransferase activities. Inflammatory cells produce chemical oxidants (HOCl, HOBr, ONO(2)(-)) that will react with polyphenols. The isoflavones daidzein and genistein and the flavonol quercetin form mono- and dichlorinated products in reaction with HOCl. Genistein is converted to 3'-nitrogenistein in the lung tissue of lipopolysaccharide-treated rats. Whereas polyphenols that can be converted to quinones or epoxides react with glutathione (GSH) to form adducts, chlorinated isoflavones do not react with GSH; instead, they are converted to β-glucuronides and are excreted in bile. Analysis of polyphenols and their metabolites is routinely carried out with great sensitivity, specificity and quantification by LC-tandem mass spectrometry. Critical questions about the absorption and tissue uptake of complex polyphenols such as the proanthocyanins can be answered by labeling these polyphenols with (14)C-sucrose in plant cell culture and then purifying them for use in animal experiments. The (14)C signature is quantified using accelerator mass spectrometry, a technique capable of detecting one (14)C atom in 10(15) carbon atoms. This permits the study of the penetration of the polyphenols into the interstitial fluid, the fluid that is actually in contact with non-vascular cells. 相似文献