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Filip Hromcik Jan Vokurka Michal Kyr Lydie Izakovicova Holla 《European Journal of Lipid Science and Technology》2021,123(2):2000259
The topical application of aspirin and omega-3 polyunsaturated fatty acids (PUFAs) may trigger the resolution of inflammation by inducing the biosynthesis of pro-resolvers such as lipoxins and resolvins while also avoiding the side effects of systemic aspirin intake. This study assessed the effect of enhanced granulation tissue (EGT) on periodontal tissue regeneration through the local application of aspirin and omega-3 PUFAs directly to granulation tissue (GT) during periodontal surgery. This randomized controlled experiment assesses 38 pockets in 19 patients. In every patient, two similar intrabony periodontal defects are treated with an open flap debridement, one with EGT (GT extracted, enhanced with aspirin and omega-3 PUFAs, and replaced) and the other with standard GT removal. Clinical attachment level (CAL) and probing pocket depth (PPD) are assessed at baseline and 2 and 6 months after surgery. The experimental protocol (EGT) results in a greater CAL gain as compared to that in the controls at 6 months (p < 0.05), while PPD reduction is not affected. The retained GT does not compromise healing. EGT is proposed as a promising, inexpensive, and simple method that may improve the outcome of periodontal regenerative treatment. However, the described protocol requires optimization and further assessment. Practical Applications : The biosynthesis of mediators including resolvins and lipoxins triggered by aspirin and omega-3 PUFAs promote the resolution of inflammation, eventually leading to faster regeneration of inflamed tissues. While granulation tissue is a necessary component in wound healing, enhancing granulation tissue with aspirin and omega-3 PUFAs results in CAL gain in the surgical treatment of periodontal defects. Retained granulation tissue does not compromise periodontal healing. The EGT strategy is an inexpensive and simple method that may improve the clinical outcomes of regenerative periodontal procedures. 相似文献
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Mark Olokotum Marc Troussellier Arthur Escalas Sahima Hamlaoui William Okello Ronald Semyalo Jean-François Humbert Cécile Bernard 《Journal of Great Lakes research》2021,47(4):985-996
Eutrophication of Lake Victoria led to changes in its phytoplankton communities. However, different levels of eutrophication exist in the open lake and the bays, and between embayments. This study utilized spatial and temporal sampling of Napoleon Gulf and Murchison Bay, exhibiting different trophic conditions. Over one year, we investigated phytoplankton biomass, richness, diversity and dissimilarity, and related the dynamics of the dominant species to the limnological and climatic conditions. The results confirmed that Napoleon Gulf and Murchison Bay showed large differences in eutrophication status, with lower nutrient concentrations in Napoleon Gulf than in Murchison Bay, where a strong gradient was observed from inshore to offshore areas. These nutrient dynamics resulted in a 4 to 10 fold higher chlorophyll-a in Murchison Bay than in Napoleon Gulf. From the embayments, 135 phytoplankton taxa were recorded with no significant differences in alpha diversity. However, high dissimilarity in community structure was observed in beta diversity, mostly due to a turnover among the dominant toxigenic species. Thus, from a similar species pool, there was a shift in the dominant toxigenic cyanobacteria from Microcystis flos-aquae and M. aeruginosa in Murchison Bay, Dolichospermum circinale and Planktolyngbya circumcreta in Napoleon Gulf to D. circinale in the offshore stations. These cyanobacteria are toxigenic taxa with known health hazards. Using partial least square models, we showed that both climatic variables (e.g. wind, solar radiation) and levels of inorganic dissolved nutrients (e.g. SRP, NO3–, and NH4+) are the main drivers of differences and dominance in cyanobacteria communities in northern Lake Victoria. 相似文献
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Lydie du Bousquet Masahide Nakamura Ben Yan Hiroshi Igaki 《Innovations in Systems and Software Engineering》2009,5(3):181-196
A home network system consists of multiple networked appliances, intended to provide more convenient and comfortable living
for home users. Before being deployed, one has to guarantee the correctness, the safety, and the security of the system. Here,
we present the approach chosen to validate the Java implementation of a home network system. We rely on the Java Modelling
Language to formally specify and validate an abstraction of the system.
This is a substantially revised version of our paper that appeared in the proceedings of the Workshop On Leveraging Applications
of Formal Methods, Verification and Validation (ISoLA), Poitiers-Futuroscope, France, December 2007. 相似文献
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S Brady CM Hiam R Saemann L Humbert MZ Fleming K Dawkins-Brickhouse 《Canadian Metallurgical Quarterly》1996,32(6):573-578
The treatment of "dual diagnosis", co-occurring substance abuse and mental illness, calls for addressing two serious and often confounding problems. The authors introduce an expanded version of the transtheoretical model of change as formulated by J.O. Prochaska and C.C. DiClemente, and suggest that this new version offers a pragmatic approach to the conceptualization and treatment of dual diagnosis. The potential utility of the treatment model is presented through the authors' experiences in working with inner-city, chronic mentally ill individuals with substance abuse problems. Practical guidelines for dual diagnosis group therapy are discussed. 相似文献
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Joseph Conroy Gregory Gremillion Badri Ranganathan J. Sean Humbert 《Autonomous Robots》2009,27(3):189-198
Insects are capable of robust visual navigation in complex environments using efficient information extraction and processing
approaches. This paper presents an implementation of insect inspired visual navigation that uses spatial decompositions of
the instantaneous optic flow to extract local proximity information. The approach is demonstrated in a corridor environment
on an autonomous quadrotor micro-air-vehicle (MAV) where all the sensing and processing, including altitude, attitude, and
outer loop control is performed on-board. The resulting methodology has the advantages of computation speed and simplicity,
hence are consistent with the stringent size, weight, and power requirements of MAVs. 相似文献