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排序方式: 共有147条查询结果,搜索用时 15 毫秒
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Carmen de Jesús-Gil Lídia Sans-de San Nicols Ester Ruiz-Romeu Marta Ferran Laura Soria-Martínez Irene García-Jimnez Anca Chiriac Josep Manel Casanova-Seuma Josep Manel Fernndez-Armenteros Sherry Owens Antonio Celada Michael D. Howell Ramn María Pujol Luis Francisco Santamaria-Babí 《International journal of molecular sciences》2021,22(4)
Candida albicans (CA) infections have been associated with psoriasis onset or disease flares. However, the integrated immune response against this fungus is still poorly characterized in psoriasis. We studied specific immunoglobulins in plasma and the CA response in cocultures of circulating memory CD45RA− cutaneous lymphocyte antigen (CLA)+/− T cell with autologous epidermal cells from plaque and guttate psoriasis patients (cohort 1, n = 52), and also healthy individuals (n = 17). A complete proteomic profile was also evaluated in plaque psoriasis patients (cohort 2, n = 114) regarding their anti-CA IgA levels. Increased anti-CA IgA and IgG levels are present in the plasma from plaque but not guttate psoriasis compared to healthy controls. CA cellular response is confined to CLA+ T cells and is primarily Th17. The levels of anti-CA IgA are directly associated with CLA+ Th17 response in plaque psoriasis. Proteomic analysis revealed distinct profiles in psoriasis patients with high anti-CA IgA. C-C motif chemokine ligand 18, chitinase-3-like protein 1 and azurocidin were significantly elevated in the plasma from plaque psoriasis patients with high anti-CA levels and severe disease. Our results indicate a mechanism by which Candida albicans exposure can trigger a clinically relevant IL-17 response in psoriasis. Assessing anti-CA IgA levels may be useful in order to evaluate chronic psoriasis patients. 相似文献
3.
Authentication and authorization in many distributed systems rely on the use of cryptographic credentials that in most of
the cases have a defined lifetime. This feature mandates the use of mechanisms able to determine whether a particular credential
can be trusted at a given moment. This process is commonly named validation. Among available validation mechanisms, the Online Certificate Status Protocol (OCSP) stands out due to its ability to carry
near real time certificate status information. Despite its importance for security, OCSP faces considerable challenges in
the computational Grid (i.e. Proxy Certificate’s validation) that are being studied at the Global Grid Forum’s CA Operations
Work Group (CAOPS-WG). As members of this group, we have implemented an OCSP validation infrastructure for the Globus Toolkit
4, composed of the CertiVeR Validation Service and our Open GRid Ocsp (OGRO) client library, which introduced the Grid Validation Policy. This paper summarizes our experiences on that work and the results obtained up to now. Furthermore we introduce the prevalidation concept, a mechanism analogous to the Authorization Push-Model, capable of improving OCSP validation performance in Grids.
This paper also reports the results obtained with OGRO’s prevalidation rules for Grid Services as a proof of concept.
相似文献
Oscar MansoEmail: |
4.
Emna B. Saafi‐Ben Salah Guido Flamini Amira El Arem Manel Issaoui Samia Dabbou Leila BenYahia Ali Ferchichi Mohamed Hammami Lotfi Achour 《International Journal of Food Science & Technology》2012,47(9):1903-1908
This paper reports a discrimination study based on the physico‐chemical characteristics, fatty acids and profile of volatile compounds of the seeds from seven date palm varieties (Phoenix dactylifera L.) grown in Tunisia. Date seeds contained 10.49–14.76% moisture; 6.28–11.2% fat (on a dry weight basis); 2.67–12.85% protein; 0.91–6.06% reducing sugar; 0.61–2.98% sucrose and 0.97–1.17% ash. Gas liquid chromatography revealed that the oil fraction of the date palm seeds contained eighteen fatty acids, with oleic acid (30.77–42.50%) and lauric acid (18.51–27.48%) as the main unsaturated and saturated ones. Volatile profile showed differences among varieties. In total, forty‐five compounds were identified, mainly alcohols, aldehydes and unsaturated hydrocarbons ones. This study provides evidence that the seeds of date may be a potential source of valuable nutrients with interesting functionality. 相似文献
5.
Faten Nasri Manel Zouari Mohamed Kharrat Maher Dammak Florence Vacandio Marielle Eyraud 《Transactions of the Indian Institute of Metals》2018,71(8):1827-1840
Zn and Zn–Ni alloy coatings were electrodeposited on mild steel from sulfate-based bath containing Sn as additive. The effect of Ni content on the microstructure, morphology, microhardness and the tribological behavior of these coatings were studied and discussed. Adding Sn in the sulfate bath had a significant effect on the surface morphology, particularly on the Zn–8 wt% Ni coatings. By increasing the Ni concentration from 8 to 14 wt%, the X-ray patterns showed that the phase structure of Zn–Ni alloy coatings was changed from η-phase Ni3Zn22 to γ-phase Ni5Zn21. The plastic deformation and delamination were found to be wear mechanisms for the investigated coatings. While the Zn–14 wt% Ni alloys had the best wear resistance, Zn films had the most severe wear volume loss and the highest friction coefficient. 相似文献
6.
Jorge L. Chávez-Servín Ana I. Castellote Manel Martín Ricard Chifré M. Carmen López-Sabater 《Food chemistry》2009
The medical community recommends that infant formulae should mimic human milk as far as possible, particularly in regards to long-chain polyunsaturated fatty acids (LC-PUFA). These include arachidonic acid (AA) and docosahexaenoic acid (DHA), both of which provide biochemical and functional benefits to neonates. However, LC-PUFAs are highly susceptible to oxidation and the composition of formulae must be carefully controlled. In this study, the stability of two types of LC-PUFA-supplemented milk-based powdered infant formula was evaluated over the course of 18 months storage at 25 °C and 40 °C. One contained egg yolk phospholipids (IF-EPL) and the other contained triacylglycerides (DHA and AA) synthesized by single cell oils (IF-SCO). The following parameters were monitored: peroxide values, volatile content (propanal, pentanal and hexanal), fatty acid profiles, and potential and free furfural content (5-hydroxymethyl-2-furaldehyde and 2-furaldehyde). In addition, these formulae were subjected to sensory evaluations by a panel of experts. The parameters studied revealed acceptable lipid stability in both types of formula, with better results for IF-EPL. At the end of the study period, significant deficits (p < 0.05) in linoleic acid were noted in both formulae. However, no significant decreases were observed in the other fatty acids, including AA and DHA. In regards to furfural content, both formulae exhibited a similar increase, indicative of the typical Maillard reaction characteristic of products stored for long periods. 相似文献
7.
Ines Thabti Walid Elfalleh Manel Ziadi Maria Graça Campos Ali Ferchichi 《International Journal of Food Properties》2013,16(4):842-854
Leaves and stem bark composition from Morus species (M. alba var. alba, M. alba var. rosa and M. rubra) was evaluated for its antioxidant and antimicrobial activities in order to enhance its therapeutic uses. Total phenolics and flavonoids contents were estimated in hydromethanolic and aqueous extracts. Results showed highest content in M. rubra leaves aqueous extract (1129 mg gallic acid equivalent/100 g dry weight and 816 mg gallic acid equivalent/100 g dry weight, respectively). Using 2,2-diphenyl-1-picrylhydrazyl assay, the highest antioxidant activity was obtained in aqueous stem barks extracts. M. alba var. alba has an IC50 of 2.84 mg/ml and the IC50 value of M. rubra was the highest (4.78 mg/ml). ABTS.+ (2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) method and reducing power assay were used to confirm the results from the 2,2-diphenyl-1-picrylhydrazyl test. All extracts expressed considerable free radical-scavenging properties. Hydromethanolic and aqueous extracts were tested against Staphylococcus aureus, Enterococcus feacalis, Staphylococcus epidermis, Escherichia coli, and Salmonella Typhimurium bacteria. Hydromethanolic stem bark extracts have the highest antimicrobial activities, and it may be a good antimicrobial agent for human gastrointestinal infections. This plant could be used as an additive to foods and also as a possible source to obtain new and effective herbal medicines to treat infections of multi-drug resistant strains of microorganisms. 相似文献
8.
Manel Rodríguez Ripoll Franz Heindl Christoph Lechner Vladimir Totolin Martin Jech Friedrich Bleicher 《摩擦学汇刊》2017,60(3):479-789
Machine hammer peening is a surface treatment technique originally developed for smoothening tools and mold surfaces. Treated surfaces are locally cold-worked, which results in a hardness increase and the induction of compressive residual stresses. In the present work, the feasibility of using this technique as a tool for embedding tungsten carbide hard particles on engineering-relevant substrate materials is systematically investigated. Tungsten carbide particles of three different sizes were embedded onto selected substrates using machine hammer peening. The particle embedment quality of the engineered surfaces was evaluated and correlated to the substrates' mechanical properties. The resulting tribological performance was investigated under reciprocating sliding conditions and the dominant wear mechanisms were correlated with the diameter of the embedded particles. The results show that machine hammer peening is a suitable technique for embedding hard particles in substrates of various materials, which additionally results in an enhancement in wear resistance, thus opening up a wide range of potential applications in tribologically loaded surfaces. 相似文献
9.
10.
Mousavi Fatemeh Abdi Ehsan Fatehi Parviz Ghalandarzadeh Abbas Bahrami Hossein Ali Majnounian Baris Ziadi Noura 《Bulletin of Engineering Geology and the Environment》2021,80(5):3923-3938
Bulletin of Engineering Geology and the Environment - Understanding the physical and especially mechanical properties of forest soils is very important in forest engineering operations including... 相似文献