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排序方式: 共有537条查询结果,搜索用时 15 毫秒
1.
Wastewater treatment technologies suitable for serving large populations are generally reliable and reasonably cost-effective, yet they are almost always financially inappropriate for small communities (< 2,000 p.e.). Comparative cost data suggests that waste stabilization ponds should be an attractive option for small communities, yet perceptions relating to land costs, climate and effluent quality have limited their application in the UK. This paper details typical UK land costs, climate and winter performance data for a pilot-scale waste stabilization pond with various upgrading technologies: system A, two tertiary maturation ponds in series; B, two tertiary maturation ponds in series followed by a reed bed channel; C, a control rock filter; D, an aerated rock filter; and E, a constructed wetland. System D was found to perform best, closely followed by system B. 相似文献
2.
Comparisons of Urban Travel Forecasts Prepared with the Sequential Procedure and a Combined Model 总被引:4,自引:1,他引:3
Justin D. Siegel Joaquín De Cea José Enrique Fernández Renán E. Rodriguez David Boyce 《Networks and Spatial Economics》2006,6(2):135-148
Detailed analyses and comparisons of urban travel forecasts prepared by applying the state-of-practice sequential procedure
and the solution of a combined network equilibrium model are presented. The sequential procedure for solving the trip distribution,
mode choice and assignment problems with feedback is the current practice in most transportation planning agencies, although
its important limitations are well known. The solution of a combined model, in contrast, results from a single mathematical
formulation, which ensures a well-converged and consistent result. Using a real network, several methods for solving the sequential
procedure with feedback are compared to the solution of the combined model ESTRAUS. The results of these methods are shown
to have various levels of instability. The paper concludes with a call for a new paradigm of travel forecasting practice based
on an internally consistent model formulation that can be solved to a level of precision suitable for comparing alternative
scenarios. 相似文献
3.
Claudio Alimonti Mara Lombardi Monica Cardarilli Elena Soldo 《Water Resources Management》2017,31(6):1745-1758
The quantification of soil variability is one of the most important aspects in the geo-engineering context. The uncertainty analysis is the main part of the reliability assessment for which a quantitative evaluation was performed in this study. The Reliability Index and the Probability of Failure using the First-Order Reliability Method (FORM) represents both, an effective method which is easy to implement at the same time. This work analyzes possible effects of compaction induced into the aquifer of the Scarlino Plain, caused by the extension of the hydraulic barrier for groundwater remediation. The currently implemented vertical barrier is composed of 12 wells which reach the depth of 10 m. The improvement of the project involves the construction of a further 40 clusters, each consisting of a doublet which intercepts different depths (10 and 18 m). The models of the subsoil stratigraphy and of the groundwater were built using a numerical model. The groundwater flow and the piezometric surface in the current configuration of the barrier were studied and the project configuration was evaluated. Using the Aquitard drainage model, the land subsidence was estimated to calculate the maximum admissible displacement related to exhibited goods, the so called territorial vulnerability. The evaluation analysis was performed using a traditional deterministic approach, followed by a reliability method based on probabilistic models. Finally, the respective results were reported in a soil mapping with overlapping layers. 相似文献
4.
Routis Ioannis Bardaki Cleopatra Dede Georgia Nikolaidou Mara Kamalakis Thomas Anagnostopoulos Dimosthenis 《Software and Systems Modeling》2021,20(6):2089-2109
Software and Systems Modeling - Case Management Model and Notation (CMMN) has been introduced as a graphical modeling language targeting the modeling of human-centric processes. Despite its growing... 相似文献
5.
6.
Marialucia Gallorini Viviana di Giacomo Valentina Di Valerio Monica Rapino Domenico Bosco Andrea Travan Mara Di Giulio Roberta Di Pietro Sergio Paoletti Amelia Cataldi Silvia Sancilio 《Journal of materials science. Materials in medicine》2016,27(12):186
Silver-based products have been proven to be effective in retarding and preventing bacterial growth since ancient times. In the field of restorative dentistry, the use of silver ions/nanoparticles has been explored to counteract bacterial infections, as silver can destroy bacterial cell walls by reacting with membrane proteins. However, it is also cytotoxic towards eukaryotic cells, which are capable of internalizing nanoparticles. In this work, we investigated the biological effects of Chitlac-nAg, a colloidal system based on a modified chitosan (Chitlac), administered for 24–48?h to a co-culture of primary human gingival fibroblasts and Streptococcus mitis in the presence of saliva, developed to mimic the microenvironment of the oral cavity. We sought to determine its efficiency to combat oral hygiene-related diseases without affecting eukaryotic cells. Cytotoxicity, reactive oxygen species production, apoptosis induction, nanoparticles uptake, and lysosome and autophagosome metabolism were evaluated. In vitro results show that Chitlac-nAg does not exert cytotoxic effects on human gingival fibroblasts, which seem to survive through a homoeostasis mechanism involving autophagy. That suggests that the novel biomaterial Chitlac-nAg could be a promising tool in the field of dentistry. 相似文献
7.
H. Artigas P. Cea J. Pardo F. M. Royo J. S. Urieta 《International Journal of Thermophysics》1996,17(2):347-359
Excess volumesV
E, excess viscosities
E, and excess free energies of activation of flow G*E at 298.15 and 313.15 K are reported for binary mixtures of 1-bronw-2-methypropane and each of the alcoholic isomers of I-butanol. The results were obtained from density and viscosity measurements and show positive values forV
4 and negative for both
E andG
*E for all mixtures over the entire composition range. 相似文献
8.
L. Cea J. R. French M. E. Vzquez‐Cendn 《International journal for numerical methods in engineering》2006,67(13):1909-1932
In this paper an unstructured finite volume model for quasi‐2D tidal flow with wet–dry fronts and turbulence modelling is presented, and applied to the Crouch–Roach estuarine system (Essex, U.K.). Two depth averaged turbulence models, a mixing length model and a k–ε model, are used in the numerical computations. An additional limiter to the production of turbulence due to bed friction is introduced in order to improve the performance and numerical stability of the model near wet–dry fronts. In addition to a first‐order and a second‐order schemes, an hybrid second‐order/first‐order upwind scheme which improves the accuracy of the first‐order scheme while maintaining a good numerical stability is used to discretize the convective flux. Numerical results are compared with observed current speed and water level data, with particular reference to the ability of the model to reproduce shallow water tidal harmonics. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
9.
Roberta Gonnella Roberta Zarrella Roberta Santarelli Concetta Anna Germano Maria Saveria Gilardini Montani Mara Cirone 《International journal of molecular sciences》2022,23(12)
PEL is a rare B cell lymphoma associated with KSHV that mainly arises in immune-deficient individuals. The search for new drugs to treat this cancer is still ongoing given its aggressiveness and the poor response to chemotherapies. In this study, we found that DMF, a drug known for its anti-inflammatory properties which is registered for the treatment of psoriasis and relapsing–remitting MS, could be a promising therapeutic strategy against PEL. Indeed, although some mechanisms of resistance were induced, DMF activated NRF2, reduced ROS and inhibited the phosphorylation of STAT3 and the release of the pro-inflammatory and immune suppressive cytokines IL-6 and IL-10, which are known to sustain PEL survival. Interestingly, we observed that DMF displayed a stronger cytotoxic effect against fresh PEL cells in comparison to PEL cell lines, due to the activation of ERK1/2 and autophagy in the latter cells. This finding further encourages the possibility of using DMF for the treatment of PEL. 相似文献
10.
Valentina Doldi Mara Lecchi Silva Ljevar Maurizio Colecchia Elisa Campi Giovanni Centonze Cristina Marenghi Tiziana Rancati Rosalba Miceli Paolo Verderio Riccardo Valdagni Paolo Gandellini Nadia Zaffaroni 《International journal of molecular sciences》2022,23(14)
Prostate cancer (PCa) ranges from indolent to aggressive tumors that may rapidly progress and metastasize. The switch to aggressive PCa is fostered by reactive stroma infiltrating tumor foci. Therefore, reactive stroma-based biomarkers may potentially improve the early detection of aggressive PCa, ameliorating disease classification. Gene expression profiles of PCa reactive fibroblasts highlighted the up-regulation of genes related to stroma deposition, including periostin and sparc. Here, the potential of periostin as a stromal biomarker has been investigated on PCa prostatectomies by immunohistochemistry. Moreover, circulating levels of periostin and sparc have been assessed in a low-risk PCa patient cohort enrolled in active surveillance (AS) by ELISA. We found that periostin is mainly expressed in the peritumoral stroma of prostatectomies, and its stromal expression correlates with PCa grade and aggressive disease features, such as the cribriform growth. Moreover, stromal periostin staining is associated with a shorter biochemical recurrence-free survival of PCa patients. Interestingly, the integration of periostin and sparc circulating levels into a model based on standard clinico-pathological variables improves its performance in predicting disease reclassification of AS patients. In this study, we provide the first evidence that circulating molecular biomarkers of PCa stroma may refine risk assessment and predict the reclassification of AS patients. 相似文献