Immunohistochemical localization of p21(WAF1/CIP1) in normal, hyperplastic, and neoplastic uterine tissues

Assuming that the chemical reactions used to synthesize a combinatorial library member are successful, then knowledge of the specific reaction sequence is equivalent to knowing the member's chemical identity. Because the determination of chemical identity is typically not automatable and requires a substantial amount of material, schemes that encode a member's reaction history onto the reaction platform are of value. The primary benefits of encoding are relational nomenclature (all methods) and automated handling (some methods). Encoding methods evaluated to date are spatial, graphical, chemical, spectrometric, electronic, and physical.     

The transient to steady-state transition during the spray-rolling process

From the geometrical standpoint, this article presents a qualitative theoretical analysis and prediction of the transient to steady-state transition during the spray-rolling process, a novel manufacturing technique for aluminum strips. The analytical results indicate that, when the deposited materials at the specific points on one roll surface overlap their counterparts on the other roll surface, spray rolling transits from the transient state to the steady state. The specific points are the limiting deposition positions of the atomized droplets on the roll surface initially.     

The effects of attrition on baseline comparability in randomized experiments in education: A meta-analysis.

Using meta-analysis, randomized experiments in education that either clearly did or clearly did not experience student attrition were examined for the baseline comparability of groups. Results from 35 studies suggested that after attrition, the observed measures of baseline comparability of groups did not differ more than would be expected given sampling error. The degree of either overall or differential attrition did not relate to baseline comparability, a finding that held under sensitivity analyses. Also, both overall and differential attrition rates were unrelated to posttest effect sizes. All of these analyses, however, lacked sufficient statistical power to detect small but potentially meaningful effects. Results suggest caution is warranted when applying quality scales and other blanket rules pertaining to attrition that are meant to either serve as inclusion-exclusion criteria or in scoring study quality. Much greater attention is needed to both the reporting of attrition in primary studies and to the development of conceptual and empirical models of the attrition process. These developments would aid further investigation of the relation between attrition and study outcomes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cutoff frequencies and noise power law model of spectral density:adaptation of the multivariance method for irregularly spaced timingdata using the lowest-mode estimator approach

The concept of structure functions, which is an extension of the variance approach, is useful to determine the variance (the structure function) which is optimized for a type of noise and for an order of drift. The multivariance method was developed to use different variances over the same signal. It is then possible to select a set of variances in which each variance is optimized to the determination of one parameter (of one noise level, drift, or cutoff frequency). Recently, we adapted this method to irregularly spaced timing data. In this connection, we replaced the structure functions by another method of spectral density estimation: the lowest-mode estimator, introduced by J.E. Deeter and P.E. Boynton (1982, 1984) for the analysis of pulsar timing data. Different lowest-mode estimators can be constructed according to two priorities: the order of drifts that must be removed and the type of noise for which the sensitivity must be maximum. Thus, a multivariance system is developed using a set of different estimators. The details of this method are described, and the results for different signals are discussed in this paper     

The synthesis of symmetrical and unsymmetrical P1/P1' cyclic ureas as HIV protease inhibitors

Cyclic urea SD146, a potent HIV protease inhibitor bearing a flat resistance profile, possessed poor solubility and bioavailability, which precluded further development of the compound. In an effort to improve upon the pharmacokinetic profile of the compound, several analogs modified at the P1/P1' residues were prepared and evaluated. Several of those compounds displayed significant improvement of physical properties.     

A modified model and algorithm for flow‐enhanced crystallization—Application to fiber spinning

The graft copolymerization of acrylamide (AAm) monomer onto polyethylene‐coated polypropylene (PE‐co‐PP) nonwoven fabric was carried out by the mutual irradiation method. The general peculiarities of the grafting have been studied by gravimetric, scanning electron microscope (SEM), mechanical properties, and Fourier transform infrared (FTIR) methods. The influence of absorbed dose, dose rate, as well as the monomer concentration on the degree of grafting has been determined. Metal ions uptake of Cu²⁺, Co²⁺, Ni²⁺ by the grafted fabrics was evaluated. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 3240–3245, 2006     

Oriented structure formation during polymer film extrusion

An experimental technique is described for producing fiberreinforced polymer films by inserting needle-like obstructions in a film-extrusion die. The, needles act as nucleation sites, generating a highly extensional local flow field, which causes sufficient orientation to induce the formation of oriented fibrillar crystallites embedded in a much less oriented matrix. To study the effectiveness of the above technique, linear low density polyethylene (LLDPE) and blends of linear low density with high density polyethylene (HDPE) were extruded through a film die with converging walls, with one or five needles inserted parallel to the extrusion direction, Microscopy observations, birefringence, and differential scanning calorimetry (DSC) measurements performed on the produced films showed in all cases that the presence of the needle induced the formation of a more oriented phase, which in most cases had a birefringence at least an order of magnitude higher than the film matrix. The best results were obtained in the case when blends of HDPE and LLDPE were extruded. The oriented structures obtained in this case consisted of HDPE and exhibited not only high birefringence but melting point elevation as well, indicating their fibrous nature.     

Analysis of the mechanical performance of a cardiovascular stent design based on micromechanical modelling

Stents are very commonly used in the treatment of coronary heart disease. They are permanent vascular support structures that offer a preferred alternative to bypass surgery in certain situations. The purpose of this work is to examine the mechanical behaviour of a stainless steel balloon expandable stent design using computational micromechanics in the context of the finite element method. Deployment and cardiac pulsing loading conditions are considered. Classical phenomenological plasticity theory (J₂ flow theory) and physically based crystal plasticity theory are used to describe the stent material behaviour. Parametric studies are carried out using both constitutive theories with a view to determining important stent deployment characteristics such as recoil and foreshortening. Comparisons of the results obtained using both theories illustrate differences, with the crystal plasticity theory models showing closer agreement to published performance data. The implications of this for stent design are discussed.     

Fabrication of long-length high-strength single-mode silica fibres

The letter reports an alternative approach to the realisation of long, low-attenuation, high-strength single-mode optical fibres suitable for high bit-rate transmission over long distances in adverse environments. We show that low attenuation (less than 0.45 dB km) can be achieved in combination with high proof-test levels (1% ? 2% strain) in fibre lengths greater than 5 km, using natural fused-quartz tubing, and report a 15 km fibre having an attenuation of 0.44 dB km which survived a proof test at 1% strain.     

Apple,Carrot, and Hibiscus Edible Films Containing the Plant Antimicrobials Carvacrol and Cinnamaldehyde Inactivate Salmonella Newport on Organic Leafy Greens in Sealed Plastic Bags

The objective of this study was to investigate the antimicrobial effects of carvacrol and cinnamaldehyde incorporated into apple, carrot, and hibiscus‐based edible films against Salmonella Newport in bagged organic leafy greens. The leafy greens tested included organic Romaine and Iceberg lettuce, and mature and baby spinach. Each leafy green sample was washed, dip inoculated with S. Newport (10⁷ CFU/mL), and dried. Each sample was put into a Ziploc® bag. Edible films pieces were put into the Ziploc bag and mixed well. The bags were sealed and stored at 4 °C. Samples were taken at days 0, 3, and 7 for enumeration of survivors. On all leafy greens, 3% carvacrol films showed the best bactericidal effects against Salmonella. All 3 types of 3% carvacrol films reduced the Salmonella population by 5 log₁₀ CFU/g at day 0 and 1.5% carvacrol films reduced Salmonella by 1 to 4 log₁₀ CFU/g at day 7. The films with 3% cinnamaldehyde showed 0.5 to 3 log reductions on different leafy greens at day 7. The films with 0.5% and 1.5% cinnamaldehyde and 0.5% carvacrol also showed varied reductions on different types of leafy greens. Edible films were the most effective against Salmonella on Iceberg lettuce. This study demonstrates the potential of edible films incorporated with carvacrol and cinnamaldehyde to inactivate S. Newport on organic leafy greens.