Inclined hot-wire response equations for a flow field having a dominant tangential velocity component

Modified sets of response equations have been derived for a single inclined hot-wire probe introduced in various orientations in a flow field having a dominant tangential velocity component. By means of these equations, the components of the three dimensional mean velocity vectors, the turbulence intensity and the Reynolds stresses can be easily determined at any location in a swirling flow which is stationary with time. This method is particularly applicable to the characterization of the flow field in chemical processing equipment where this type of swirling flow is increasingly being used. It has been successfully applied to a study of the flow field in a spray-drying chamber, in the course of which good reproducibility and consistency of results were obtained.     

Estimation of diffusion coefficient for solute–polymer systems

Diffusion coefficients are needed for the analysis of many mass transfer problems involving polymers. Since the diffusivity for such systems are strong functions of temperature and concentration, the analysis of these problems is greatly facilitated if predictive methods are available for the determination of the required diffusion coefficient. Because of the limitations of the theoretical approaches for estimating diffusivity, empirical correlation of solute–polymer diffusion coefficient data with physical properties of the solute were investigated. Chemical permeation measurements were made for several organic liquids through three elastomers (polychoroprene, butyl and nitrile rubber) at five different temperatures, ranging from 25 to 65°C. The collected diffusivities were correlated with liquid kinematic viscosity. Diffusivities (at different temperatures) depend mainly on the kinematic viscosity of solutes. The results also indicate a close relation between the variation of diffusivity and viscosity with temperature.     

Accelerated convergence for a normal state layered superconductor’s transverse resistance expression,measured with strip contacts

The expression of the transverse resistance for an ohmic parallelepipedic layered conductor, measured with strip contacts, extended along its width, is a slowly convergent series. This series is reworked and transformed to the sum of an analytical part and an exponentially convergent series, which reduces considerably the number of terms needed for the numerical evaluation. In addition, an asymptotic formula is obtained, valid for Γ < 2, Γ is the effective anisotropy. This formula is used to determine the room temperature resistivity anisotropy of two small Γ layered superconductors, which are 2H–NbSe₂ and 2H–TaSe₂.     

Real-time processing and compression of DNA microarray images.

In this paper, we present a pipeline architecture specifically designed to process and compress DNA microarray images. Many of the pixilated image generation methods produce one row of the image at a time. This property is fully exploited by the proposed pipeline that takes in one row of the produced image at each clock pulse and performs the necessary image processing steps on it. This will remove the present need for sluggish software routines that are considered a major bottleneck in the microarray technology. Moreover, two different structures are proposed for compressing DNA microarray images. The proposed architecture is proved to be highly modular, scalable, and suited for a standard cell VLSI implementation.     

Acquisition of high-precision images for non-contact atomic force microscopy

The atomic force microscope (AFM) system has evolved into a useful tool for direct measurements of intermolecular forces with atomic-resolution characterization that can be employed in a broad spectrum of applications. The distance between cantilever tip and sample surface in non-contact AFM is a time-varying parameter even for a fixed sample height, and typically difficult to identify. A remedy to this problem is to directly identify the sample height in order to generate high-precision atomic-resolution images. For this, the microcantilever (which forms the basis for the operation of AFM) is modeled as a single mode approximation and the interaction between the sample and cantilever is derived from a van der Waals potential. Since in most practical applications only the microcantilever deflection is accessible, we will use merely this measurement to identify the sample height. In most non-contact AFMs, cantilevers with high-quality factors are employed essentially for acquiring high-resolution images. However, due to high-quality factor, the settling time is relatively large and the required time to achieve a periodic motion is long. As a result, identification methods based on amplitude and phase measurements cannot be efficiently utilized. The proposed method overcomes this shortfall by using a small fraction of the transient motion for parameter identification, so the scanning speed can be increased significantly. Furthermore, for acquiring atomic-scale images of atomically flat samples, the need for feedback loop to achieve setpoint amplitude is basically eliminated. On the other hand, for acquiring atomic-scale images of highly uneven samples, a simple PI controller is designed to track the desired constant sample height. Simulation results are provided to demonstrate the feasibility of the approach for both sample height identification and tracking the desired sample height.     

IMPACCT: Methodology and Tools for Power-Aware Embedded Systems

Power-aware systems are those that must exploit a widerange of power/performance trade-offs in order to adapt to the power availabilityand application requirements. They require the integration of many novel powermanagement techniques, ranging from voltage scaling to subsystem shutdown.However, those techniques do not always compose synergistically with eachother; in fact, they can combine subtractively and often yield counterintuitive,and sometimes incorrect, results in the context of a complete system. Thiscan become a serious problem as more of these power aware systems are beingdeployed in mission critical applications.To address the problem of technique integration for power-aware embedded systems, we propose a new design tool framework called IMPACCT and the associated design methodology. The system modeling methodology includes application model for capturing timing/powerconstraints and mode dependencies at the system level. The tool performs power-awarescheduling and mode selection to ensure that all timing/power constraintsare satisfied and that all overhead is taken into account. IMPACCT then synthesizesthe implementation targeting a symmetric multiprocessor platform. Experimentalresults show that the increased dynamic range of power/performance settingsenabled a Mars rover to achieve significant acceleration while using lessenergy. More importantly, our tool correctly combines the state-of-the-arttechniques at the system level, thereby saving even experienced designersfrom many pitfalls of system-level power management.     

Petrographic and petrophysical characterization of some Paleozoic rocks,Um Bogma area,Southwest Sinai,Egypt

Sixty-two samples were collected from the five formations at Um Bogma area, (Southwest Sinai, Egypt). Nine samples were collected from Sarabit El Khedim Formation, ten samples were collected from Abu Hamata Formation, eighteen samples were collected from Adedia Formation, eight samples were collected from Um Bogma Formation and eighteen samples were collected from Abu Thora Formation.The Paleozoic rocks at Um Bogma area, consist mainly of sandstones, siltstones, shales, limestone and dolostones, which are unconformably overlie igneous and metamorphic rocks (granite, diorite and gneiss) of Precambrian age.The petrographic studies were applied to identify different rock units, different facies and its diagenetic history and to reveal its effect on the storage capacity properties. Different types of porosity (oversized, intergranular, fracture and vuggy porosities) have been identified based on the petrographic investigation of the studied thin sections.The Paleozoic sandstone rock samples are characterized by porosity average about 19% for Facies 1 (quartz wack) and about 18%for Facies 2 (quartz arenite) and permeability average 420?mD for Facies 1 (quartz wack) and 690?mD for Facies 2 (quartz arenite), so these rocks can be considered as good reservoir rocks. The Paleozoic carbonate rock samples (Facies 3) are characterized by poor porosity (less than 7%) and very low permeability (less than 0.5?mD), which caused by matrix and diagenetic processes and refer to bad reservoir rocks.Porosity can be linked to the two derived electrical properties (formation resistivity factor and electrical tortuosity) of the studied Paleozoic rocks at Um Bogma area. The electrical tortuosity has significant effects on both permeability and formation resistivity factor. The permeability decreases with increasing electrical tortuosity and the relation between both of them is inverse relationship with good coefficient of correlation. The permeability decreases with increasing electrical tortuosity and the relations between both of them are inverse relationships with high coefficient of correlation. The formation resistivity factor increases with increasing electrical tortuosity and the relations between both of them are positive relationships with a fair to very high coefficient of correlation.     

Supramolecular Assembly of Aminoethylene‐Lipopeptide PMO Conjugates into RNA Splice‐Switching Nanomicelles

Phosphorodiamidate morpholino oligomers (PMOs) are oligonucleotide analogs that can be used for therapeutic modulation of pre‐mRNA splicing. Similar to other classes of nucleic acid‐based therapeutics, PMOs require delivery systems for efficient transport to the intracellular target sites. Here, artificial peptides based on the oligo(ethylenamino) acid succinyl‐tetraethylenpentamine (Stp), hydrophobic modifications, and an azide group are presented, which are used for strain‐promoted azide‐alkyne cycloaddition conjugation with splice‐switching PMOs. By systematically varying the lead structure and formulation, it is determined that the type of contained fatty acid and supramolecular assembly have a critical impact on the delivery efficacy. A compound containing linolenic acid with three cis double bonds exhibits the highest splice‐switching activity and significantly increases functional protein expression in pLuc/705 reporter cells in vitro and after local administration in vivo. Structural and mechanistic studies reveal that the lipopeptide PMO conjugates form nanoparticles, which accelerate cellular uptake and that the content of unsaturated fatty acids enhances endosomal escape. In an in vitro Duchenne muscular dystrophy exon skipping model using H2K‐mdx52 dystrophic skeletal myotubes, the highly potent PMO conjugates mediate significant splice‐switching at very low nanomolar concentrations. The presented aminoethylene‐lipopeptides are thus a promising platform for the generation of PMO‐therapeutics with a favorable activity/toxicity profile.     

Nested and interleaved direct sequence spread spectrum to enhance CDMA security and bit error rate performance

Two new methods, the nested direct sequence spread spectrum and interleaved direct sequence spread spectrum, are introduced in view of the previously investigated spread spectrum methods. In the nested direct sequence method, the security is maintained, and the cross‐correlation between different codes resulting in multi‐user interference that corresponds to BER performance is improved, while in the interleaved direct sequence spread spectrum, the security is improved and BER performance is maintained. Both methods are analysed by mathematical relations as well as computer simulations and are compared with the existing methods. Copyright © 2016 John Wiley & Sons, Ltd.