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1.
Wu JC Lai CS Badmaev V Nagabhushanam K Ho CT Pan MH 《Molecular nutrition & food research》2011,55(11):1646-1654
Scope: Autophagy (type II programmed cell death) is crucial for maintaining cellular homeostasis. Several autophagy‐deficient or knockout studies indicate that autophagy is a tumor suppressor. Tetrahydrocurcumin (THC), a major metabolite of curcumin, has been demonstrated with anti‐colon carcinogenesis and antioxidation in vivo. Methods and results: In the present study, we found that treatment with THC induced autophagic cell death in human HL‐60 promyelocytic leukemia cells by increasing autophage marker acidic vascular organelle (AVO) formation. Flow cytometry also confirmed that THC treatment did not increase sub‐G1 cell population whereas curcumin did with strong apoptosis‐inducing activity. At the molecular levels, the results from Western blot analysis showed that THC significantly down‐regulated phosphatidylinositol 3‐kinase/protein kinase B and mitogen‐activated protein kinase signalings including decreasing the phosphorylation of mammalian target of rapamycin, glycogen synthase kinase 3β and p70 ribosomal protein S6 kinase. Further molecular analysis exhibited that the pretreatment of 3‐methyladenine (an autophagy inhibitor) also significantly reduced acidic vascular organelle production in THC‐treated cells. Conclusion: Taken together, these results demonstrated the anticancer efficacy of THC by inducing autophagy as well as provided a potential application for the prevention of human leukemia. 相似文献
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L S Vaidhyanathan A M Niraimathi P Majumdar G Rangarajan M Muralidhar D Mangapathi Rao M Nagabhushanam V Hari Babu 《Bulletin of Materials Science》1991,14(4):913-919
Bi2−x
Pb
x
Sr2Ca2Cu3O
y
superconducting samples with 0<x<0·3 have been synthesized and characterized using X-ray powder diffraction.T
c
and superconducting volume fraction have been measured using a.c. magnetic susceptibility, d.c. electrical resistivity as
well as X-band microwave surface resistance in the normal state. The data indicate the growth of the highT
c
(2223) phase with corresponding reduction of the lowT
c
(2122) phase with increasingx, up to 0·25. Beyond this value ofx there is a slight deterioration of the superconducting behaviour. 相似文献
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D. Mohan Ganga Radhakrishnan S. Rajadurai T. Nagabhushanam K. Thomas Joseph 《应用聚合物科学杂志》1984,29(1):329-339
Poly(butyl acrylate) has been graft copolymerized onto casein using potassium peroxydisulfate–ascorbic acid as the initiating system. The proof of grafting has been obtained by ninhydrin test and IR studies. The effects of synthetic variables in the graft copolymerization have been discussed in the light of percent grafting, grafting efficiency, and the rates of polymerization. 相似文献
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M. Thomas S. Satish N. Kalyanam 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》1983,33(5):232-236
A four step synthesis of methylallene, a chain transfer agent, from 1, 3-butadiene is described. Effects of experimental variables on the yields of the products in the various steps have been studied. The products obtained are characterised primarily with the use of proton magnetic resonance spectroscopy. 相似文献
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Summary The reactivity ratios of styrene and acrylonitrile were computed from the 13C-NMR spectra of copolymers prepared using cobalt acetylacetonate-triethylaluminum initiator system and compared with a free radical initiator such as AIBN. The results indicate that polymerization using the former has pronounced free radical characteristics. 相似文献
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S. B. Clough D. Cortelek T. Nagabhushanam J. C. Salamone A. C. Watterson 《Polymer Engineering and Science》1984,24(5):385-390
Small angle neutron scattering experiments were made on an ionomer synthesized from perdeuterostyrene and an ion pair comonomer. A Debye plot based on data from the sample with lower ion concentration gave a correlation length of 5.3A. Clustering is not significant in this sample. With a higher concentration of ionic groups a peak in the scattering curve is interpreted as due to clusters about 20A in diameter. These studies along with X-ray scattering and electron microscopy also indicate the presence of larger ion rich domains. 相似文献
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L. Di Pace C. Rizzello A. Natalizio K. Kalyanam R. Matsugu R. Caporali 《Journal of Fusion Energy》1997,16(1-2):55-65
The safety aspects of a fusion reactor fuel cycle, which handles substantial quantities of tritium, have been assessed in the framework of the European Programme on Safety and Environmental Assessment of Fusion Power Long Term (SEAL). This study focused on the assessment of the tritium inventory that could be released from interlinked systems in accidental scenarios. A systematic review of the fuel cycle systems was performed by focusing attention on the main interfaces and to the possible propagation of accident sequences through these interfaces. For the bounding accident sequences identified, deterministic analyses were carried out to determine the accident consequences. Both process source terms (PST) and environmental source terms (EST) were estimated. Simultaneous failure of the primary and secondary containment was considered to be beyond the design basis, nevertheless a preliminary analysis has been carried out; a bounding accident sequence related to a double failure, involving a hydrogen fire, has led to a tritium environmental release of 5.3 g and the wall mechanical load deriving from the maximum hypoth-esizable hydrogen detonation has been defined. Tritium releases into the secondary containment are treated by the appropriate detritiation and by the vent detritiation system. The related EST has been estimated based on an overall tritium cleanup efficiency of 99%, deliberately chosen low to cause the EST to be overestimated. The maximum tritium environmental release is less than 11 g and corresponds to an in-vessel LOCA. For accidents initiating in the fuel cycle only, the maximum tritium release is at most 3.1 g. 相似文献