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排序方式: 共有96条查询结果,搜索用时 62 毫秒
1.
Federico Paolini Paoletti Simone Simoni Lucilla Parnetti Lorenzo Gaetani 《International journal of molecular sciences》2021,22(9)
Brain small vessel disease (SVD) refers to a variety of structural and functional changes affecting small arteries and micro vessels, and manifesting as white matter changes, microbleeds and lacunar infarcts. Growing evidence indicates that SVD might play a significant role in the neurobiology of central nervous system (CNS) neurodegenerative disorders, namely Alzheimer’s disease (AD) and Parkinson’s disease (PD), and neuroinflammatory diseases, such as multiple sclerosis (MS). These disorders share different pathophysiological pathways and molecular mechanisms (i.e., protein misfolding, derangement of cellular clearance systems, mitochondrial impairment and immune system activation) having neurodegeneration as biological outcome. In these diseases, the actual contribution of SVD to the clinical picture, and its impact on response to pharmacological treatments, is not known yet. Due to the high frequency of SVD in adult-aged patients, it is important to address this issue. In this review, we report preclinical and clinical data on the impact of SVD in AD, PD and MS, with the main aim of clarifying the predictability of SVD on clinical manifestations and treatment response. 相似文献
2.
Giovanni Bellettini Valentina Beorchia Maurizio Paolini 《Journal of Mathematical Imaging and Vision》2008,32(3):265-291
We introduce and study a two-dimensional variational model for the reconstruction of a smooth generic solid shape E, which may handle the self-occlusions and that can be considered as an improvement of the 2.1D sketch of Nitzberg and Mumford
(Proceedings of the Third International Conference on Computer Vision, Osaka, 1990). We characterize from the topological viewpoint the apparent contour of E, namely, we characterize those planar graphs that are apparent contours of some shape E. This is the classical problem of recovering a three-dimensional layered shape from its apparent contour, which is of interest
in theoretical computer vision. We make use of the so-called Huffman labeling (Machine Intelligence, vol. 6, Am. Elsevier,
New York, 1971), see also the papers of Williams (Ph.D. Dissertation, 1994 and Int. J. Comput. Vis. 23:93–108, 1997) and the paper of Karpenko and Hughes (Preprint, 2006) for related results. Moreover, we show that if E and F are two shapes having the same apparent contour, then E and F differ by a global homeomorphism which is strictly increasing on each fiber along the direction of the eye of the observer.
These two topological theorems allow to find the domain of the functional ℱ describing the model. Compactness, semicontinuity
and relaxation properties of ℱ are then studied, as well as connections of our model with the problem of completion of hidden
contours.
相似文献
Maurizio PaoliniEmail: |
3.
Paolini Emilio De Marinis Lorenzo Cococcioni Marco Valcarenghi Luca Maggiani Luca Andriolli Nicola 《Neural computing & applications》2022,34(18):15589-15601
Neural Computing and Applications - Photonics-based neural networks promise to outperform electronic counterparts, accelerating neural network computations while reducing power consumption and... 相似文献
4.
Chiara Paolini Silvia Agarbati Devis Benfaremo Matteo Mozzicafreddo Silvia Svegliati Gianluca Moroncini 《International journal of molecular sciences》2022,23(7)
Systemic sclerosis (SSc) is a clinically heterogeneous disorder of the connective tissue characterized by vascular alterations, immune/inflammatory manifestations, and organ fibrosis. SSc pathogenesis is complex and still poorly understood. Therefore, effective therapies are lacking and remain nonspecific and limited to disease symptoms. In the last few years, many molecular and cellular mediators of SSc fibrosis have been described, providing new potential options for targeted therapies. In this review: (i) we focused on the PDGF/PDGFR pathway as key signaling molecules in the development of tissue fibrosis; (ii) we highlighted the possible role of stimulatory anti-PDGFRα autoantibodies in the pathogenesis of SSc; (iii) we reported the most promising PDGF/PDGFR targeting therapies. 相似文献
5.
Znini Mohamed Cristofari Gregory Majidi Lhou El Harrak Abdelhay Paolini Julien Costa Jean 《Food science and biotechnology》2013,22(1):113-119
Essential oil of aerial parts of Warionia saharae was obtained by hydrodistillation and analyzed by GC and GC-MS. Thirty-nine compounds were identified, accounting for 93.2% of the total oil. β-Eudesmol (34.9%), nerolidol-E (23%), and linalool (15.2%) were the most abundant components. The antifungal activity of the W. saharae oil was tested by poisoned food (PF) technique and the volatile activity (VA) assay against 3 phytopathogenic causing the deterioration for apple. The results indicated that the W. saharae oil inhibited significantly the mycelial growth of all strains tested (p<0.05). The minimum inhibitory concentration against Alternaria sp. was 2 μL/mL air in VA assay, whereas >2 μL/mL in PF technique for all strains. Fungal spore production was completely inhibited at 1 μL/mL air for Alternaria sp. and at 2 μL/mL air for Penicillium expansum and Rhizopus stolonifer. 相似文献
6.
7.
U Della Casa M Picchio U Passaro A Lombardi G Ramacciato PM Amodio A Paolini 《Canadian Metallurgical Quarterly》1997,52(6):705-712
Resistance to benzalkonium chloride (BC) among Pseudomonas spp. isolated from poultry carcasses was determined and strategies for elimination of resistant strains evaluated. This investigation showed that resistance was quite common, about 30% of the isolates being able to grow in 200 micrograms ml-1 BC. Pseudomonas fluorescens strains were generally less susceptible than strains of Ps. lundensis and Ps. fragi. An overnight incubation in medium containing 200 micrograms ml-1 BC was sufficient to reduce the susceptibility of two Pseudomonas strains to the lethal effect of BC significantly. Adding EDTA enhanced the lethal effect of BC, but the effect was reduced after growing cells in medium containing BC and EDTA. Growth in medium with a quaternary ammonium compound (QAC) rendered the cells more susceptible to chlorine, phenolics, and alkylaminoacetate. These results indicate that alternating use of QACs with these compounds can be used to avoid build-up of resistant strains. In addition, increased temperatures improved the lethal effect of BC and should be considered when planning disinfection routines. 相似文献
8.
9.
This study compares the performance characteristics of laboratory-scale activated sludge and rotating biological contactor (RBC) units treating an industrial effluent. It is found that, within the range of hydraulic detention time examined (0.3–1.7 days), the two plants show very similar BOD5 removal kinetics. These results indicate that an RBC unit with a geometrical area of the discs of 1340 cm21−1 of aeration reactor is equivalent to an activated sludge plant with an MLVSS concentration of about 2000 mg 1−1. Experimental data from the two units are also analyzed by two steady-state kinetic models. It is proved that the kinetic constants of suspended microbial growths may be used successfully for fixed biological films. At the same time, a simplified design equation for RBC systems is verified and an estimation procedure for the effective surface area of the biofilm developed. 相似文献
10.
In the context of a multilevel database management system architecture, the problem arises of translating, or mapping, operations at the user's representation level (the External Schema) into operations at the system's common logical level (the Conceptual Schema).In order to support different structured user's data models, the need for an unstructured, view-independent and yet carefully defined data model at the Conceptual Schema level is recognized.In this paper a binary model for the Conceptual Schema is illustrated through the specification of a set of primitives, and the elements of a language for the definition of a binary Schema and of the corresponding operations are given.Procedures are then illustrated for translating external into conceptual operations through exploitation of the primitives of the binary model. Two types of mapping specifications are illustrated: the operational mapping, in which the translation is explicitly defined, and the structural mapping, in which only the structural correspondences between elements of the External and the Conceptual Schema are defined. The automatic mapping between n-ary relational views and the binary Conceptual Schema is finally discussed. 相似文献