Impact of air‐handling system exhaust failure on dissemination pattern of simulant pathogen particles in a clinical biocontainment unit

Biocontainment units (BCUs) are facilities used to care for patients with highly infectious diseases. However, there is limited guidance on BCU protocols and design. This study presents the first investigation of how HVAC (heating, ventilation, air‐conditioning) operating conditions influence the dissemination of fluorescent tracer particles released in a BCU. Test conditions included normal HVAC operation and exhaust failure resulting in loss of negative pressure. A suspension of optical brightener powder and water was nebulized to produce fluorescent particles simulating droplet nuclei (0.5‐5 μm). Airborne particle number concentrations were monitored by Instantaneous Biological Analyzers and Collectors (FLIR Systems). During normal HVAC operation, fluorescent tracer particles were contained in the isolation room (average concentration = 1 × 10⁴ ± 3 × 10³/L_air). Under exhaust failure, the automated HVAC system maximizes airflow into areas adjacent to isolation rooms to attempt to maintain negative pressure differential. However, 6% of the fluorescent particles were transported through cracks around doors/door handles out of the isolation room via airflow alone and not by movement of personnel or doors. Overall, this study provides a systematic method for evaluating capabilities to contain aerosolized particles during various HVAC scenarios. Recommendations are provided to improve situation‐specific BCU safety.     

Experimental study on the compressive resistance of stress-relieved solid round steel members

The Canadian Standard for Antenna Towers and Antenna Supporting Structures, CSA-S37-01, specifies expressions for the compressive resistance of solid rounds based on the Structural Stability Research Council (SSRC) Column Curves for non-solid-round members and the results from experimental investigations on the compressive resistance of solid rounds carried out back to 1965. Similar Standard in USA (TIA/EIA-222-G.0) specifies design criteria for such members as derived from the superseded AISC-LRFD-94 Standard, which is independent of the shape of the member cross-section. The European Standard, Eurocode 3, provides column curves for the compressive resistance of various structural steel members, and assumes the applicability of one of them to solid rounds. As such, it is necessary to conduct an experimental study on solid round stress-relieved steel members to refine the available design equations for such members. This paper provides a summary of the literature review on solid rounds as well as a recent test program conducted on stress-relieved steel solid rounds. Correlation between the results from these tests and the current practice for the design of solid rounds is investigated. The paper concludes with a proposed compressive resistance equation for economical design of such members.     

User-perceived quality of service in wireless data networks

For so long, the term quality of service (QoS) has been a pursuit area for network engineers trying to dimension wireless networks to run in the most efficient way possible. Of late, there has been a trend reversal, looking at the user perceptions of the network performance to decide where dimensioning can have the greatest impact. This paper demonstrates the importance of defining the concept of user-perceived QoS and linking this to specific wireless data network parameters for some anticipated valuable applications. It has been shown that a quantitative rating can be obtained for a variety of important factors in the assessment of service quality, and mapped to specific values of multiple network parameters. We found QoS to be application-specific, where various applications require different levels of network performance to satisfy users. The role of physical location was also examined, investigating the influence of being indoors versus outdoors on the user perception of QoS.     

The comparison of the corrosion resistance of advanced ferromagnetic stainless steels by Mott–Schottky approach

Ferromagnetic stainless steels (SSs) have been investigated as potential candidates for dental prosthesis applications in replacement of magnetic attachments made of noble and expensive alloys. In order to be used as biomaterials, their corrosion resistance has to be appropriate. The corrosion resistance of passive materials is related to the characteristics of the passive film formed and their properties might be investigated by electrochemical impedance spectroscopy (EIS), potentiodynamic polarization curves, and Mott–Schottky approach. The corrosion resistance and the capacitance of the passive films formed on PM2000, DIN 1.4575, and 17‐4 PH advanced SSs during 2 days of immersion in a phosphate buffered saline solution (PBS), at 25 °C and pH 7.0 were studied by electrochemical techniques. A commercial alloy Dyna EFM was also analyzed for comparison reasons. The results showed that films on tested materials behave as both n‐type and p‐type semiconductors and the PM2000 presented the highest corrosion resistance among all of them.     

Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment

PURPOSE: Irinotecan (CPT-11), a camptothecin derivative, has shown efficacy against colorectal cancer. Delayed-onset diarrhea is its main limiting toxicity. The aim of this study was to determine the pathophysiology of CPT-11-induced delayed-onset diarrhea and assess the efficacy of combined antidiarrheal medication in a phase II, prospective, successive-cohorts, open study. PATIENTS AND METHODS: Twenty-eight patients with advanced colorectal cancer refractory to fluorouracil (5-FU) therapy received CPT-11 350 mg/m2 every 3 weeks. The first cohort of 14 consecutive patients explored for the mechanism of diarrhea received acetorphan (a new enkephalinase inhibitor) 100 mg three times daily; the second 14-patient cohort received, in addition to acetorphan, loperamide 4 mg three times daily. Before treatment, and if late diarrhea occurred, patients underwent colon mucosal biopsies for CPT-11 and topoisomerase I levels; intestinal transit time; fecalogram; fat and protein excretion; alpha1-antitrypsin clearance; D-xylose test; blood levels for vasoactive intestinal polypeptide, glucagon, gastrin, somatostatin, prostaglandin E2, and carboxylesterase; CPT-11/SN-38 and SN-38 glucuronide pharmacokinetics; and stool cultures. RESULTS: Delayed-onset diarrhea occurred during the first three treatment cycles in 23 patients (82%). Electrolyte fecal measurements showed a negative or small osmotic gap in nine of nine patients and an increased alpha1-antitrypsin clearance in six of six patients. There were no modifications in stool cultures or hormonal dysfunction. Four of 11 patients (36%) with delayed-onset diarrhea in the first cohort responded to acetorphan, whereas nine of 10 patients (90%) responded to the combination of acetorphan and loperamide (P < .02). CONCLUSION: CPT-11-induced delayed-onset diarrhea is caused by a secretory mechanism with an exudative component. Early combined treatment with loperamide and acetorphan seems effective in controlling the diarrheal episodes.     

Consumer rejection threshold for 1,8-cineole (eucalyptol) in Australian red wine

The compound 1,8-cineole is known to elicit the perception of eucalyptus flavour. There is debate over whether eucalyptus flavour is positive or should be considered a taint in red wine. The current experiment measured a consumer rejection threshold (CRT) in red wine, using samples spiked with increasing concentrations of cineole. Results estimated the CRT in red wine at 27.5 ppb. Analysis of a post-experiment questionnaire suggested that preference for cineole is not significantly influenced by gender, age, level of experience or prior experience, though these results were based on a small sample. Results suggest that a moderate intensity of eucalyptus character in red wine should not be considered a taint and that some consumers may consider moderate intensities preferable to no eucalyptus character. The CRT determined allows quantitative decisions to be made in response to measured levels of cineole in red wine. Winemakers and wine marketers considering promoting eucalyptus character as a taste dimension in wine now have a quantitative basis on which to be guided.     

Temporal design for additive manufacturing

The International Journal of Advanced Manufacturing Technology - Additive manufacturing (AM) is expected to generate huge economic revenue by 2025; however, this will only be realised by overcoming...     

Plasmonic‐Induced Photon Recycling in Metal Halide Perovskite Solar Cells

Organic–inorganic metal halide perovskite solar cells have emerged in the past few years to promise highly efficient photovoltaic devices at low costs. Here, temperature‐sensitive core–shell Ag@TiO₂ nanoparticles are successfully incorporated into perovskite solar cells through a low‐temperature processing route, boosting the measured device efficiencies up to 16.3%. Experimental evidence is shown and a theoretical model is developed which predicts that the presence of highly polarizable nanoparticles enhances the radiative decay of excitons and increases the reabsorption of emitted radiation, representing a novel photon recycling scheme. The work elucidates the complicated subtle interactions between light and matter in plasmonic photovoltaic composites. Photonic and plasmonic schemes such as this may help to move highly efficient perovskite solar cells closer to the theoretical limiting efficiencies.