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European Food Research and Technology - Die Analyse und Identifizierung von Aromastoffen mittels GC/MS-Technik aus Holunderbeeren und -blüten wird beschrieben. Durch Extraktion mit...  相似文献   
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We show that, under in vitro conditions, the vulnerability of astroglia to hypoxia is reflected by alterations in endothelin (ET)-1 release and capacity of erythropoietin (EPO) to regulate ET-1 levels. Exposure of cells to 24 h hypoxia did not induce changes in ET-1 release, while 48–72 h hypoxia resulted in increase of ET-1 release from astrocytes that could be abolished by EPO. The endothelin receptor type A (ETA) antagonist BQ123 increased extracellular levels of ET-1 in human fetal astroglial cell line (SV-FHAS). The survival and proliferation of rat primary astrocytes, neural precursors, and neurons upon hypoxic conditions were increased upon administration of BQ123. Hypoxic injury and aging affected the interaction between the EPO and ET systems. Under hypoxia EPO decreased ET-1 release from astrocytes, while ETA receptor blockade enhanced the expression of EPO mRNA and EPO receptor in culture-aged rat astroglia. The blockade of ETA receptor can increase the availability of ET-1 to the ETB receptor and can potentiate the neuroprotective effects of EPO. Thus, the new therapeutic use of combined administration of EPO and ETA receptor antagonists during hypoxia-associated neurodegenerative disorders of the central nervous system (CNS) can be suggested.  相似文献   
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Zusammenfassung Die Analyse und Identifizierung von Aromastoffen mittels GC/MS-Technik aus Holunderbeeren und -blüten wird beschrieben. Durch Extraktion mit flüssigem CO2 konnte erstmals die Aromavorstufe 3,7-Dimethyl-octa-1,5-dien-3,7-diol in Holunder nachgewiesen werden. Über identifizierte Monoterpene, die vermutlich aus Diolvorstufen entstehen, wird berichtet.
Analysis of volatile components in elderberry2. Communication: Investigation of the monoterpenes
Summary The analysis and identification of flavour compounds from elderberry juices and flowers using GC/MS-technique is described. The flavour precursor 3,7-dimethyl-octa-1,5-dien-3,7-diole was isolated for the first time; this was accomplished by extraction with liquid carbon dioxide. Several other monoterpenes extracted from juices and flowers were identified; they possibly originate from such diol precursors.
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Microfluidic chips applied to the investigation of chirality allow reaction, separation and analysis of minuscule amounts of enantiomeric molecules. Chiral chip technology is employed in fields as diverse as pharmaceutical high throughput screening and deep space exploration missions.  相似文献   
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Colorectal cancer remains one of the most important health challenges in our society. The development of cancer immunotherapies has fostered the need to better understand the anti-tumor immune mechanisms at play in the tumor microenvironment and the strategies by which the tumor escapes them. In this review, we provide an overview of the molecular interactions that regulate tumor inflammation. We particularly discuss immunomodulatory cell-cell interactions, cell-soluble factor interactions, cell-extracellular matrix interactions and cell-microbiome interactions. While doing so, we highlight relevant examples of tumor immunomodulation in colorectal cancer.  相似文献   
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This paper provides a deduction-based approach for automatically classifying compound-internal relations in GermaNet, the German version of the Princeton WordNet for English. More specifically, meronymic relations between simplex and compound nouns provide the necessary input to the deduction patterns that involve different types of compound-internal relations. The scope of these deductions extends to all four meronymic relations modeled in version 6.0 of GermaNet: component, member, substance, and portion. This deduction-based approach provides an effective method for automatically enriching the set of semantic relations included in GermaNet.  相似文献   
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