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Kandhasamy Sowndhararajan Souren Paul Gi Seok Kwon Cher Won Hwang Sun Chul Kang 《Food science and biotechnology》2014,23(3):711-716
The anti-ulcer activity of polyamine extract (PAE) of salt stressed and sprouted soybean seeds against ethanol-induced gastric damage was investigated in a rat model. The contents of the polyamines putrescine (20.11%), spermidine (9.46%), and spermine (2.79%) in PAE were determined using HPLC. The anti-ulcer activity of the extract was compared with the effects of the reference drug omeprazole. Pre- and post-administration of PAE at doses of 10+10, 20, and 20+20mg/kg of body weight in conjunction with ethanol administration significantly protected ethanolinduced gastric damage. The levels of superoxide dismutase and glutathione in stomach tissues were significantly changed, when compared with an ethanol control group. Polyamine extract exhibited high protective effect against ulcer lesions and could be used to develop new anti-ulcer drugs. 相似文献
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Kandhasamy Sowndhararajan Jince Mary Joseph 《International Journal of Food Properties》2013,16(8):1717-1729
The acetone and methanol extracts of barks of A. leucophloea, A. ferruginea, A. dealbata, and A. pennata were evaluated for their total phenolics and flavonoid contents and antioxidative activities. Acetone extracts of barks exhibited higher contents of total phenolics and flavonoids. Further, the acetone extracts showed higher activity in DPPH?, ABTS?+, and OH?; FRAP; metal chelation; phosphomolybdenum reduction; and peroxidation inhibition. In conclusion, the results implied that the barks could be considered as health supplements and nutraceuticals/functional foods. 相似文献
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Kandhasamy?Sowndhararajan Perumal?Siddhuraju Sellamuthu?ManianEmail author 《Food science and biotechnology》2011,20(3):585-591
Antioxidant activity of 70% acetone extracts of raw and processed seeds of Jack bean (Canavalia ensiformis L. DC) was evaluated by various in vitro antioxidant assays, including total antioxidant, free radical scavenging, reducing
power, metal ion chelating, β-carotene/linoleic acid bleaching, and antihemolytic activities. The total phenolics and tannin
contents were higher in the extract of seeds processed by autoclaving with 1% ash solution (3.2 and 1.6 g/100 g extract, respectively).
In general, all the extracts of processed seeds exhibited higher activity in various antioxidant systems, when compared to
raw seeds but significant differences were noticed between processing methods. The extract of seeds autoclaved with 1% sugar
solution showed higher DPPH radical scavenging activity (IC50 10.6 mg/mL). Interestingly, the extract of dry heated seeds registered higher inhibition of hemolysis (76.1%) compared to
standards butylated hydroxyanisole (BHA) (66.2%) and α-tocopherol (59.3%) at the concentration of 500 μg/mL. 相似文献
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Dhilin Pathayappurakkal Mohanan Nimegha Pathayappurakkal Mohan Nandakumar Selvasudha Saranya Thekkilaveedu Ruckmani Kandasamy 《应用聚合物科学杂志》2021,138(43):51280
The present work deals with the preparation and characterization of lignin based macromolecular polymeric composites and applications thereof. Here lignin is complexed with pectin and/ or gellan gum, to form two different macromolecular green composites LP and LPG. The best ratios screened out through evaluation of nanoparticle characterization and rheology, then confirmed by surface morphology. The superior thermal stability is proved by DSC analysis. The reaction groups involving in complexation are confirmed by FT-IR spectroscopic evaluation where the methoxy or methyl group of lignin interacts with the hydroxyl group of pectin and gellan gum to form nanocomposites. The reduced particle size and surface charge confirm the complexation due to interaction between ionizable functional groups. The applications of these composites are validated by their dye adsorption capacity and anti-microbial properties (after loading of green silver nanoparticles) which proves the multifunctional properties of novel composites. The maximum dye removal efficiency of both composites is independent of initial dye concentration. Dye adsorption capacity is best fitted by Freundlich adsorption isotherms that follow pseudo-second-order adsorption kinetics. The antibacterial study of developed silver nanoparticle loaded and unloaded composites shows wide spectrum activity against E. coli and S. aureus, with higher inhibition efficiency against gram-negative organism. 相似文献
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Kandhasamy Sowndhararajan Perumal Siddhuraju Sellamuthu Manian 《Food science and biotechnology》2010,19(2):503-509
Antioxidant potential and total phenolics content of 70% acetone extracts of the raw and processed seeds of Bauhinia vahlii were evaluated. The extract of raw seeds contained higher levels of total phenolics (30.8 g/100 g) and tannins (19.6 g/100
g) compared to dry heated and soaking followed by autoclaving seed extracts. Extracts were screened for antioxidant and free
radical scavenging activities using various chemical and in vitro model systems. In all the models, except DPPH radical scavenging activity, the extract from raw seeds manifested the strongest
antioxidant activity than that from processed seeds. In β-carotene/linoleic acid emulsion system and superoxide scavenging
activity, the raw seed extract registered more activity when compared to the standards (butylated hydroxyanisole and α-tocopherol).
Whereas, the extract from dry heated seed exhibited higher DPPH· scavenging activity (IC50 70.77 μg/mL) than the raw seeds (IC50 74.4 μg/mL). This study has to some extent validated the antioxidant potential of the seeds of B. vahlii. 相似文献
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Brabu Balusamy Yamuna Gowri Kandhasamy Anitha Senthamizhan Gopalakrishnan Chandrasekaran Murugan Siva Subramanian Kumaravel Tirukalikundram S 《中国稀土学报(英文版)》2012,30(12):1298-1302
This study evaluated the bacterial toxicity of lanthanum oxide micron and nano sized particles using shake flask method against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria. Particle size, morphology and chemical composition were determined using scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS). Re-sults indicated that lanthanum oxide nanoparticles showed antimicrobial activity against Staphylococcus aureus, but not against Escherichia coli and Pseudomonas aeruginosa. It was speculated that lanthanum oxide produced this effect by interacting with the gram-positive bacte-rial cell wall. Furthermore, lanthanum oxide bulk particles were found to enhance the pyocyanin pigment production in Pseudomonas aeruginosa.) 相似文献
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Niosome vesicles of cytarabine hydrochloride were prepared by a lipid hydration method that excluded dicetylphosphate. The sizes of the vesicles obtained ranged from 600 to 1000 nm, with the objective of producing more blood levels in vivo. The study of the release of drug from niosomes exhibited a prolonged release profile as studied over a period of 16 hr. The drug entrapment efficiency was about 80% with Tween 80, Span 60 and Tween 20; for Span 80, it was 67.5%. The physical stability profile of vesicular suspension was good as studied over a period of 4 weeks. 相似文献
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Chandrasekar Ponnusamy Abimanyu Sugumaran Venkateshwaran Krishnaswami Ruckmani Kandasamy Subramanian Natesan 《IET nanobiotechnology / IET》2019,13(8):868
Age‐related macular degeneration (AMD) is a disease affecting the macula by the new blood vessels formation. AMD is widely treated with a combination of anti‐angiogenic and anti‐vascular endothelial growth factor (VEGF) agents. The topical administration of nanodispersions showed enhanced ocular residence time with controlled and prolonged drug delivery to the disease site at the back of the eye. In the present study we developed and characterized nanodispersion containing anti‐angiogenic (artemisinin) and anti‐VEGF agent (dexamethasone) for the topical ocular administration in order to obtain a required drug concentration in the posterior part of the eye. The nanodispersions were prepared with varying concentration of polymer, polyvinyl pyrrolidone K90 and polymeric surfactant, Poloxamer 407. The nanodispersions were found to be smooth and spherical in shape with a size range of 12–26 nm. In‐vitro drug release studies showed the 90–101% of artemisinin and 55–103% of dexamethasone release from the nanodispersions. The blank formulation with a high concentration of polymer and polymeric surfactant showed an acceptable level of haemolysis and DNA damage. The chorioallantoic membrane assay suggested that the nanodispersion possess good anti‐angiogenic effect. Hence the formulated artemisinin and dexamethasone nanodispersion may have the great potential for the AMD treatment.Inspec keywords: drug delivery systems, drugs, eye, blood vessels, DNA, biochemistry, nanofabrication, molecular biophysics, nanomedicine, diseases, biomedical materials, polymers, membranesOther keywords: topical administration, enhanced ocular residence time, controlled prolonged drug delivery, disease site, eye, topical ocular administration, polymeric surfactant, dexamethasone release, dexamethasone nanodispersion, AMD treatment, blood vessel formation, drug concentration, in‐vitro drug release, antiangiogenic effect, artemisinin, dexamethasone loaded topical nanodispersion, age‐related macular degeneration effective treatment, antivascular endothelial growth factor agents, antiangiogenic endothelial growth factor agents, antiVEGF agent, polyvinyl pyrrolidone K90, polymer concentration, Poloxamer 407, size 12.0 nm to 26.0 nm, chorioallantoic membrane assay, DNA damage, haemolysis 相似文献