Temperature/pH/magnetic triple‐sensitive nanogel–hydrogel nanocomposite for release of anticancer drug

Hydrogels, nanogels and nanocomposites show increasing potential for application in drug delivery systems due to their good chemical and physical properties. Therefore, we were encouraged to combine them to produce a new compound with unique properties for a long‐term drug release system. In this regard, the design and application of a nanocomposite hydrogel containing entrapped nanogel for drug delivery are demonstrated. To this aim, we first prepared an iron oxide nanocomposite nanogel based on poly(N‐isopropylacrylamide)‐co‐((2‐dimethylaminoethyl) methacrylate) (PNIPAM‐co‐PDMA) grafted onto sodium alginate (NaAlg) as a biocompatible polymer and iron oxide nanoparticles (ION) as nanometric base (PND/ION‐NG). This was then added into a solution of PDMA grafted onto NaAlg. Through dropwise addition of mixed aqueous solution of iron salts into the prepared polymeric solution, a novel hydrogel nanocomposite with excellent pH, thermal and magnetic responsivity was fabricated. The synthesized samples were fully characterized using Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy with energy‐dispersive X‐ray analysis, vibrating sample magnetometry and atomic force microscopy. A mechanism for the formation of PNIPAM‐co‐PDMA/NaAlg‐ION nanogel–PDMA/NaAlg‐ION hydrogel and PND/ION nanogel is suggested. Swelling capacity was measured at various temperatures (25 to 45 °C), pH values (from 2 to 11) and magnetic field and under load (0.3 psi) and the dependence of swelling properties of the nanogel–hydrogel nanocomposite on these factors was well demonstrated. The release rate of doxorubicin hydrochloride (DOX) as an anticancer drug was studied at different pH values and temperatures in the presence and absence of a magnetic field. The results showed that these factors have a high impact on drug release from this nanocomposite. The result showed that DOX release could be sustained for up to 12.5 days from these nanocomposite hydrogels, significantly longer than that achievable using the constituent hydrogel or nanogel alone (<1 day). The results indicated that the nanogel–hydrogel nanocomposite can serve as a novel nanocarrier for anticancer drug delivery. © 2019 Society of Chemical Industry     

A new adaptation of mapping method to study mixing of multiphase flows in mixers with complex geometries

The main objective of the present work is to modify the traditional mapping method for the simulation of distributive mixing of multiphase flows in geometries involving moving parts such as, internal mixers or twin-screw extruders without a limitation on their geometrical periodicity. The periodicity condition, limits the results of traditional mapping method to tracking mapping mesh between specific discrete time intervals or distances for that geometry is repeated, hence, result is only for fixed orientation of rotors. Imaginary domain method is introduced to track mapping mesh from one state to the next free of geometrical periodicity limitations. In this work the method is introduced and its applicability and accuracy is discussed in details. A two-dimensional (2D) simulation of mixing of two Newtonian fluids with different viscosities in an intermeshing internal mixer is used as a test case study. In this example the key issues of ability to predict mixing state in details for all orientations of rotors is presented. To reduce diffusion errors of mapping method in the boundaries of the rotors, mapping mesh refinement technique that relies upon one single reference mesh is also presented.     

On the modal incremental dynamic analysis

In this article a new technique for the dynamic response of structures is investigated. This applied procedure can predict the approximate seismic performance of the structures and it is fast, inexpensive and results are reasonably acceptable. In fact, this novel method logically combines two different techniques, ‘incremental dynamic analysis (IDA)’ and ‘modal pushover analysis (MPA)’, presented by other researchers. This method will take advantage of both methodical ideas such as equivalent single degree of freedom of multi‐degree structures and the implementation of different scaled level of an earthquake record to the provided equivalent SDF structure. Using this procedure, simple approximate curves that present a realistic linear and non‐linear seismic behaviour of the structure due to the applied scaled level of earthquakes can easily be extracted. In this investigation, several four‐, eight‐ and 12‐storey structures are specified as the example models and are dynamically analysed. Next, three different scaled earthquakes, El Centro, Northridge and San Fernando, are applied to each example problem. The results of the presented technique, modal incremental dynamic analysis (MIDA), are then compared with the IDA method. Comparison of the results reveals good accuracy in building seismic demands evaluation. Finally, it is also shown that the MIDA method is simple enough to be carried out on most personal computers and the authors believe this technique will serve design engineers working in real design conditions. Copyright © 2005 John Wiley & Sons, Ltd.     

Using genetic algorithm for the optimization of seismic behavior of steel planar frames with semi-rigid connections

Beam-column connections have a significant role in the results of the analysis and the design of steel frames. In this paper, a genetic algorithm has been used for the non-linear analysis and design of steel frames. For minimizing the weight of frames, while satisfying the applied constraints and restraints such as the limits of normal and combined stresses, criteria such as target displacement(s) and the number and locations of plastic hinges were used. To analyze and design the frame elements, I and box-shaped standard sections were used for beams and columns, respectively. Finally, some clues for finding optimizing semi-rigid connection stiffness values for beam-to-column connections have been obtained. The degrees of these rigidities are obtained by a genetic algorithm during the procedure of optimization in order to reach a frame with the minimum weight. SAP2000 structural analysis program was used to perform modal analysis and linear and non-linear static solutions as well as the design of the elements. A MATLAB program was written for the process of optimization. The procedure of optimization was based on a weight minimization carried out for 9 steel frames. Thus, the optimum connection stiffness could be obtained for minimizing the weight of the structure. The results show that the non-linear analysis gives less weight for short period frames with semi-rigid connections compared to those of linear ones. However, by increasing the periods of frames, much less weights are obtained in the case of non-linear analysis with semi-rigid connections.     

Portability of three consumer products

Three consumer products (a television set, a personal computer and a typewriter), all considered portable by their respective manufacturers, were evaluated experimentally for portability. Products were not considered portable if the physical and subjective workloads resulting from carrying them over specified distances were excessive. Twenty-two males and six females participated in the experimental investigation and carried the three products for distances of 45·72, 91·44. 137·16 and 182·88 m. Their pulse and ratings of perceived exertion (RPE) of the arms and whole body were recorded and used as measures of physical and perceived workloads. Both physiological and subjective responses to carrying products were significantly influenced by the type of product and carrying distance, regardless of the gender of the person performing the carrying. The results of this study and the design guidelines provided in the literature for one-handed and two-handed carrying tasks led to the conclusion that, of the three products, only the television set could be considered portable.     

A four-bias three-layer graphene-based THz absorber

Wave absorbers are considered to be fundamental building blocks for the manipulation of light. Almost all optical systems exploit absorbers to realize some functions. A highly tunable wide-band THz absorber is presented herein. Utilizing a dual-bias scheme with a single graphene layer leads to greater freedom to control the absorption response, while a conventional periodic array of graphene ribbons and a layer of graphene sheet are also exploited. Also, a circuit model representation for all the constituent parts of the proposed absorber is developed with an evolved design methodology. According to the simulation results, wide-band absorption from 3.5 to 6 THz is achieved.

     

Finite-time coordination in multiagent systems using sliding mode control approach

Finite-time stability in dynamical systems theory involves systems whose trajectories converge to an equilibrium state in finite time. In this paper, we use the notion of finite-time stability to apply it to the problem of coordinated motion in multiagent systems. Specifically, we consider a group of agents described by fully actuated Euler–Lagrange dynamics along with a leader agent with an objective to reach and maintain a desired formation characterized by steady-state distances between the neighboring agents in finite time. We use graph theoretic notions to characterize communication topology in the network determined by the information flow directions and captured by the graph Laplacian matrix. Furthermore, using sliding mode control approach, we design decentralized control inputs for individual agents that use only data from the neighboring agents which directly communicate their state information to the current agent in order to drive the current agent to the desired steady state. Sliding mode control is known to drive the system states to the sliding surface in finite time. The key feature of our approach is in the design of non-smooth sliding surfaces such that, while on the sliding surface, the error states converge to the origin in finite time, thus ensuring finite-time coordination among the agents in the network. In addition, we discuss the case of switching communication topologies in multiagent systems. Finally, we show the efficacy of our theoretical results using an example of a multiagent system involving planar double integrator agents.