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排序方式: 共有3702条查询结果,搜索用时 15 毫秒
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Alfredo M. Gravagnuolo Eden Morales‐Narváez Charlene Regina Santos Matos Sara Longobardi Paola Giardina Arben Merkoçi 《Advanced functional materials》2015,25(38):6084-6092
Class I hydrophobin Vmh2, a peculiar surface active and versatile fungal protein, is known to self‐assemble into chemically stable amphiphilic films, to be able to change wettability of surfaces, and to strongly adsorb other proteins. Herein, a fast, highly homogeneous and efficient glass functionalization by spontaneous self‐assembling of Vmh2 at liquid–solid interfaces is achieved (in 2 min). The Vmh2‐coated glass slides are proven to immobilize not only proteins but also nanomaterials such as graphene oxide (GO) and quantum dots (QDs). As models, bovine serum albumin labeled with Alexa 555 fluorophore, anti‐immunoglobulin G antibodies, and cadmium telluride QDs are patterned in a microarray fashion in order to demonstrate functionality, reproducibility, and versatility of the proposed substrate. Additionally, a GO layer is effectively and homogeneously self‐assembled onto the studied functionalized surface. This approach offers a quick and simple alternative to immobilize nanomaterials and proteins, which is appealing for new bioanalytical and nanobioenabled applications. 相似文献
3.
Zusammenfassung Dieser Artikel beschreibt einige Erfahrungen und typische Problemstellungen mit Textmining in der Medizin und gibt einen Einblick
in aktuelle und zukünftige Herausforderungen in Forschung & Entwicklung. Interessant ist n?mlich, dass auch im ,,Multimedia-Zeitalter“
die meiste Information immer noch als ,,Text“ vorliegt. Mithilfe von statistischen und linguistischen Verfahren wird mit sogenannter
,,Textmining-Software“ versucht, aus Freitexten Information ,,heraus zu schürfen“ (deshalb ,,Textmining“). Allerdings ist
es damit noch nicht genug. Der n?chste Schritt besteht darin, die Information sowohl nutzbar als auch brauchbar zu machen.
Die jeweiligen End-Benutzerinnen und End-Benutzer müssen in die Lage versetzt werden, auf der Basis der gewonnenen Information
deren Wissen zu erweitern. In unserem konkreten Fall sollen damit Entscheidungen im Rahmen ?rztlichen Handelns unterstützt
werden. Probleml?sungen in diesem Bereich erfordern eine holistische Sicht- und Herangehensweise. Daher wird es immer wichtiger,
Erkenntnisse aus Informatik und Psychologie zusammenflie?en zu lassen und auf systemischer Ebene technologisch umzusetzen. 相似文献
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In this work a new class of numerical methods for the BGK model of kinetic equations is presented. In principle, schemes of
any order of accuracy in both space and time can be constructed with this technique. The methods proposed are based on an
explicit–implicit time discretization. In particular the convective terms are treated explicitly, while the source terms are
implicit. In this fashion even problems with infinite stiffness can be integrated with relatively large time steps. The conservation
properties of the schemes are investigated. Numerical results are shown for schemes of order 1, 2 and 5 in space, and up to
third-order accurate in time. 相似文献
6.
Stress in the parenting role has been found to be related to family functioning and parenting behavior. However, most research in this area has been conducted with clinical samples and has not compared parenting stress of mothers and fathers. In this study, 589 married couples with young children (12 to 60 months old) completed the Parenting Stress Index-Short Form (Abidin, 1990) and measures of child-rearing behaviors and attitudes, social support, and child behavior. The validity of Abidin's measure and theoretical model was tested, and results were mixed. Small effects were found for mothers and fathers, and these were moderated by child age and marital happiness. Stress as a normal consequence of parenting is discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
7.
This article describes the application, at the team and individual level, of findings from the positive psychology research. An overview of this research is presented focusing on several areas generally included in the positive psychology domain: flow, appreciative inquiry, the broaden and build theory, and other strategies for increasing the experience of positive emotions and the identification and deployment of strengths. The authors propose that these applications show promise in consulting psychology engagements and may have merit when utilized by practitioners themselves. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
8.
Myers Mark G.; MacPherson Laura; McCarthy Denis M.; Brown Sandra A. 《Canadian Metallurgical Quarterly》2003,15(2):163
The goal of the present studies was to construct and validate a short form of the 50-item Smoking Consequences Questionnaire (SCQ; T. H. Brandon & T. B. Baker, 1991), a measure of smoking outcome expectancies. In Study 1, a 21-item short form (S-SCQ) was derived from a sample of 107 young adults previously treated for substance abuse. In Study 2, the measure was cross-validated on 125 adolescents in treatment for substance abuse. Confirmatory factor analyses revealed good model fit and factorial invariance for the 4 S-SCQ subscales across both samples. Validation analyses on each sample found that subscale scores generally correlated significantly with smoking-related variables. The present studies provide initial evidence for the utility of the S-SCQ when used with young adults and adolescents. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
9.
Giuseppe G. G. Manzardo Sandra Kürsteiner-Laube und Daniel Perrin 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1996,203(6):501-506
In diethyl ether extracts from celeriac (Apium graveolens L. var.rapaceum) all four stereoisomers of (3a–7a)-cis-3-butylhexahydrophthalide were found to be present. The analyses were carried out by means of GC, enantioselective GC and GC-MS. The assignment of the relative configuration of the diastereomers3 and4 was accomplished by NOE difference spectroscopy. 相似文献
10.
Three- and 4-yr-old children were tested for comprehension of knowledge formation. In Exp 1, 34 Ss watched as a surprise was hidden under 1 of 4 obscured cups. The experimenter then pointed to the cup. All children searched under the correct cup, but no 3-yr-olds (in contrast to most 4-yr-olds) could explain how they knew where to look. Ss then discriminated between simultaneous pointing by 2 adults, one who had hidden a surprise and one who had left the room before the surprise was hidden. Most 4-yr-olds (but no 3-yr-olds) showed clear discrimination between the adults. In Exp 2, 16 Ss were tested with procedures designed to make the source of their own knowledge more obvious, but this had no effect on performance. It is concluded that studies using very similar procedures with chimpanzees and rhesus macaques were measuring an ability (or inability) to understand how knowledge states form. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献