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Ji-Hye Yoo Sarangerel Oidovsambuu Sang Min Kim Na Ra Jeon Ji Ho Yun Kyungsu Kang Eun Hye Jho Saet Byoul Lee Chu Won Nho 《Food science and biotechnology》2011,20(6):1655-1661
Handaeri-gomchi (Ligularia fischeri var. spiciformis Nakai) (LF) is well known as a medicinal plant in Korea, especially to treat a variety of human disease including hepatic
function failure. In this study, we examined the activity of LF extract against the liver injuries and oxidative stress by
chronic alcohol in Spargue-Dawley rats. Severe liver damage caused by alcohol intake with increasing activity of hepatic markers
was decreased in the group of rats fed LF extract. The results were confirmed through hematoxylin and eosin staining. Antioxidative
capacity was decreased by alcohol but it was recovered by LF extract. Elevated indicators of oxidative stress by chronic alcohol
were diminished in the group of LF extract. Furthermore, LF extracts increased antioxidative capacity and the activity of
antioxidant enzymes. In conclusion, LF extract has a protective effect against chronic alcohol hepatotoxicity, suggesting
it could be developed as a functional food or medicine for protection of liver disease. 相似文献
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