全文获取类型
收费全文 | 7679篇 |
免费 | 637篇 |
国内免费 | 295篇 |
专业分类
电工技术 | 379篇 |
技术理论 | 3篇 |
综合类 | 497篇 |
化学工业 | 1202篇 |
金属工艺 | 342篇 |
机械仪表 | 449篇 |
建筑科学 | 555篇 |
矿业工程 | 246篇 |
能源动力 | 202篇 |
轻工业 | 388篇 |
水利工程 | 143篇 |
石油天然气 | 437篇 |
武器工业 | 56篇 |
无线电 | 676篇 |
一般工业技术 | 870篇 |
冶金工业 | 1153篇 |
原子能技术 | 78篇 |
自动化技术 | 935篇 |
出版年
2024年 | 43篇 |
2023年 | 129篇 |
2022年 | 239篇 |
2021年 | 341篇 |
2020年 | 250篇 |
2019年 | 206篇 |
2018年 | 235篇 |
2017年 | 257篇 |
2016年 | 228篇 |
2015年 | 312篇 |
2014年 | 352篇 |
2013年 | 388篇 |
2012年 | 424篇 |
2011年 | 462篇 |
2010年 | 402篇 |
2009年 | 375篇 |
2008年 | 328篇 |
2007年 | 325篇 |
2006年 | 340篇 |
2005年 | 314篇 |
2004年 | 199篇 |
2003年 | 229篇 |
2002年 | 214篇 |
2001年 | 178篇 |
2000年 | 188篇 |
1999年 | 199篇 |
1998年 | 377篇 |
1997年 | 223篇 |
1996年 | 185篇 |
1995年 | 134篇 |
1994年 | 119篇 |
1993年 | 89篇 |
1992年 | 44篇 |
1991年 | 46篇 |
1990年 | 27篇 |
1989年 | 26篇 |
1988年 | 20篇 |
1987年 | 21篇 |
1986年 | 14篇 |
1985年 | 6篇 |
1984年 | 4篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 4篇 |
1980年 | 13篇 |
1977年 | 24篇 |
1976年 | 61篇 |
1975年 | 3篇 |
1955年 | 3篇 |
1951年 | 1篇 |
排序方式: 共有8611条查询结果,搜索用时 0 毫秒
1.
2.
LW Seymour H Soyez A De Marre MA Shoaibi EH Schacht 《Canadian Metallurgical Quarterly》1996,11(5):351-365
Prodrugs of mitomycin C (MMC) based on soluble poly-[N-(2-hydroxyethyl)-L-glutamine] (pHEG) polymers have been evaluated as tumour-targeted drugs. These materials are designed to exploit the enhanced permeability of tumour vasculature, combining a passive tumour tropism with decreased systemic liberation of free MMC. A tri- or tetrapeptide linkage (e.g. Gly-Phe-Ala-Leu) between pHEG and the aziridine nitrogen of MMC can combine good hydrolytic stability with rapid cleavage by lysosomal enzymes, releasing free MMC. The conjugates showed decreased systemic toxicity and could be administered to mice at a total MMC dose of 15 mg/kg i.v., compared with just 6 mg/kg for free MMC. Conjugates also showed better activity against animal models of established tumours, achieving up to 77% increased life span (ILS) against solid P388 leukaemia, compared with only 23% for free MMC, and up to 121% ILS against solid C26 colorectal carcinoma, compared with no activity for the free drug. Improving the therapeutic index of anticancer drugs by combining tumour tropism with decreased systemic toxicity is a versatile approach that should produce a new generation of improved anticancer agents. 相似文献
3.
Weijia Shang O'Keefe M.T. Fortes J.A.B. 《Parallel and Distributed Systems, IEEE Transactions on》1994,5(2):193-204
This paper describes several loop transformation techniques for extracting parallelism from nested loop structures. Nested loops can then be scheduled to run in parallel so that execution time is minimized. One technique is called selective cycle shrinking, and the other is called true dependence cycle shrinking. It is shown how selective shrinking is related to linear scheduling of nested loops and how true dependence shrinking is related to conflict-free mappings of higher dimensional algorithms into lower dimensional processor arrays. Methods are proposed in this paper to find the selective and true dependence shrinkings with minimum total execution time by applying the techniques of finding optimal linear schedules and optimal and conflict-free mappings proposed by W. Shang and A.B. Fortes 相似文献
4.
W. Shang B. Robrahn F. Golding M. H. J. Koch 《Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment》2004,530(3):513-520
A data acquisition system for time resolved X-ray scattering experiments using linear, quadrant or area gas proportional detectors with delay line readout based on commercially available hardware (National Instruments) is described. The system can easily be configured for recording data from point detectors (e.g. photomultipliers and photodiodes) and/or ancillary data only. Applications involving measurements with two different types of time to digital converters illustrate the features and performances of the system. 相似文献
5.
本文介绍了笔者设计并实现的一种新型的面向对象的程序设计语言,着重讨论了在设计过程中采用的新的概念,并和其它类似语言作了比较. 相似文献
6.
EH Eddes AM Masclee HG Gooszen M Fr?lich CB Lamers 《Canadian Metallurgical Quarterly》1997,174(4):387-392
Two mobilizable cloning vectors, designated pABW1 and pAWB2, were constructed basing on the E. coli vector pBGS18 and oriT originating from RK2. In pABW2 the kanamycin resistance gene was replaced by a novel tetracycline resistance cassette derived from Tn1721. Both vectors, specific for E. coli, allow to perform the cloning steps in E. coli and then to efficiently transfer the constructs by conjugation to the host of choice. A vector which cannot propagate in the given host can be applied for identification of the host specific plasmid replicator regions. With the use of pABW2 we defined the minimal replicator region of pTAV202-a mini-derivative of the large pTAV1 plasmid of P. versutus. We also proved that RepC' encoded on this fragment is the principal initiator replication protein and that oriV is located along its coding sequence. 相似文献
7.
8.
The EU Concerted Action Workshop on 11q23 Abnormalities in Hematological Malignancies collected 550 patients with abnormalities involving 11q23. Of these, 53 patients had a translocation involving chromosome 11, breakpoint q23, and chromosome 19, breakpoint p13. Karyogram review enabled each patient to be further defined as t(11;19)(q23;p13.1) (21 patients) or t(11;19)(q23;p13.3) (32 patients). There was a marked difference between the type of banding and the translocation identified: t(11;19)(q23;p13.1) was detected predominantly by R-banding, whereas t(11;19)(q23;p13.3) was detected almost solely by G-banding. Additional change was extremely rare in patients with t(11;19)(q23;p13.1) but occurred in nearly half of the patients with t(11;19)(q23;p13.3). Patients with t(11;19)(q23;p13.1) all had leukemia of a myeloid lineage, mostly acute myeloid leukemia (AML), and were predominantly adult. In contrast patients with t(11;19)(q23;p13.3) had malignancies of both myeloid and lymphoid lineage and were mainly infants less than 1 year old. The survival of both groups of patients was generally poor, over 50% of t(11;19)(q23;p13.1) patients died within 2 years of diagnosis and the median survival of acute lymphoblastic leukemia (ALL) patients with t(11;19)(q23;p13.3) was 17.6 months. 相似文献
9.
EH Jeffery K Abreo E Burgess J Cannata JL Greger 《Canadian Metallurgical Quarterly》1996,48(6):649-665
Although the full mechanisms are not yet elucidated, research into the mechanism of toxicity of aluminum (Al) on bone formation and remodeling and on hematopoietic tissue is ongoing. In contrast little information exists on the interactive effects of systemic Al and the kidney. In bone, both clinically and experimentally, high doses of Al inhibit remodeling, slowing both osteoblast and osteoclast activities and producing osteomalacia and adynamic bone disease. In contrast, while very low levels of Al are mitogenic in bones of experimental animals, the effect of low levels of Al in humans is unknown. Aluminum has been shown to have its mitogenic action at the osteoblast, but whether the effect on resorption is viz osteoblast-directed changes in osteoclast activity has not yet been determined. Parathyroid hormone (PTH) levels are disrupted by Al in humans and animals. Whether altered PTH levels play a major or even a minor role in Al-dependent osteotoxicity requires clarification. In hematopoietic tissue, Al causes a microcytic anemia, not reversible by iron. Friend leukemia cells treated with Al have been reported to accumulate excess iron, without incorporating it into ferritin or heme. It is not yet known which steps in iron metabolism are disrupted by Al, if they involve a single mechanism of action, or even if this disruption in iron metabolism accounts for the anemia seen in Al toxicosis. In kidney, research is needed to evaluate Al nephrotoxicity; there are almost no studies in this area. Furthermore, research is needed to evaluate mechanisms of renal Al excretion, presently shown by one study to occur at the distal tubule. Such studies might well throw light on whether Al plays a role in aggravating renal insufficiency, or whether the role of the kidney in Al toxicosis is limited to the causative effect of renal compromise on Al accumulation. In summary, while a number of mechanisms have been proposed for the toxic action of Al, no single mechanism emerges to explain these diverse effects of systemic Al. Recommendations for future research are presented and summarized in Table 1. 相似文献
10.