Reducing cycle times in manufacturing and supply chains by input and service rate smoothing

A key performance parameter of a manufacturing network or supply chain is its cycle time; the time that a typical item spends in the network. A previous simulation study on a semiconductor assembly and test facility showed that cycle times could be reduced by having smooth input and service rates. This suggested that there is a “cycle time principle” that, for a system with a specified throughput or input rate, the shortest cycle times are obtained when the input and service rates do not vary over time. We prove that this principle is true for the M/G/1 and M/M/s queueing systems and Jackson networks. The analysis involves establishing several results on the concavity of waiting time probabilities and the convexity of expected waiting times and queue lengths, as functions of input and service rates. These results also have natural uses in other optimization problems.     

Mixed oxide supported hydrodesulfurization catalysts—a review

Support effects form important aspect of hydrodesulfurization (HDS) studies and mixed oxide supports received maximum attention in the last two decades. This review will focus attention on studies on mixed oxide supported Mo and W catalysts. For convenience of discussion, these are divided into Al₂O₃ containing mixed oxide supports, TiO₂ containing mixed oxide supports, ZrO₂ containing mixed oxide supports and other mixed oxide supports containing all the rest. TiO₂ containing mixed oxides received maximum attention, especially TiO₂–Al₂O₃ supported catalysts. A brief discussion about their prospects for application to ultradeep desulfurization is also included. An overview of the available literature with emphasis on research carried out in our laboratory form the contents of this publication.     

Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses

On the basis of results of studies using high doses of estrogens, exposure to estrogen during fetal life is known to inhibit prostate development. However, it is recognized in endocrinology that low concentrations of a hormone can stimulate a tissue, while high concentrations can have the opposite effect. We report here that a 50% increase in free-serum estradiol in male mouse fetuses (released by a maternal Silastic estradiol implant) induced a 40% increase in the number of developing prostatic glands during fetal life; subsequently, in adulthood, the number of prostatic androgen receptors per cell was permanently increased by 2-fold, and the prostate was enlarged by 30% (due to hyperplasia) relative to untreated males. However, as the free serum estradiol concentration in male fetuses was increased from 2- to 8-fold, adult prostate weight decreased relative to males exposed to the 50% increase in estradiol. As a model for fetal exposure to man-made estrogens, pregnant mice were fed diethylstilbestrol (DES) from gestation days 11 to 17. Relative to controls, DES doses of 0.02, 0.2, and 2.0 ng per g of body weight per day increased adult prostate weight, whereas a 200-ng-per-g dose decreased adult prostate weight in male offspring. Our findings suggest that a small increase in estrogen may modulate the action of androgen in regulating prostate differentiation, resulting in a permanent increase in prostatic androgen receptors and prostate size. For both estradiol and DES, prostate weight first increased then decreased with dose, resulting in an inverted-U dose-response relationship.     

Parallel transport: a new transport layer paradigm for enabling Internet quality of service

The transport layer in the network protocol stack serves as a liaison between the application and the underlying network. Any quality of service provided by the network thus has to be effectively translated by the transport layer protocol in order to be enjoyed by the applications. In this article, we argue for a fundamental rethinking of the transport layer design to facilitate such QoS delivery. We identify the key requirement for a QoS enabling transport layer protocol as the ability to effectively handle multiplicity in terms of user differentiation levels, network resources, and service models. However, TCP, the transport layer protocol predominantly used in the Internet, is unable to support such multiplicity due to its single-state design. We extend TCP to a parallel transport layer protocol called parallel TCP (pTCP) that can tackle the different dimensions of multiplicity, and hence enable varying classes of QoS to applications. We discuss the applicability of pTCP in three specific domains with different levels of network support for QoS, and present simulation results substantiating our arguments.     

TFRC friendliness and the case of ECN

The TFRC protocol has been proposed as a TCP‐friendly protocol to transport streaming media over the Internet. However, its deployment is still questionable because it has not been compared to other important protocols, analysed in the presence of important mechanisms, such as the explicit congestion notification (ECN), and studied under more realistic network conditions. In this paper, we address these three aspects, including other congestion control protocols not considered before in the same investigation, such as TCP Tahoe, Reno, Newreno, Vegas, Sack, GAIMD, and the Binomial algorithms, the effect of using ECN in the friendliness of the protocols, and the fairness of the protocols under static and dynamic network conditions. We found that TFRC can be safely deployed in the Internet if competing with TCP Tahoe, New Reno and SACK since fairness is achieved under all scenarios considered. We also found that ECN actually helps in achieving better fairness. However, fairness problems arise when TFRC competes with TCP Reno, GAIMD, SQRT or IIAD in static or dynamic conditions, or both. We used normalized throughput, fairness index, and convergence time as the main performance metrics for comparison. Copyright © 2004 John Wiley & Sons, Ltd.     

Evaluation of solid-desiccant-based evaporative cooling cycles for typical hot and humid climates

This paper presents an evaluation of various solid desiccant cycles for air conditioning in hot and humid climates. Psychometric evaluation of potential cycles for 16 typical Indian cities has been carried out with the objective of achieving standard comfort conditions in the room. Computer simulation is based on constant effectiveness of heat exchangers and evaporative coolers and actual performance data of a commercially available desiccant wheel dehumidifier. The influence of various outdoor conditions, the effectiveness of heat exchangers/evaporative coolers on the cooling coefficient of performance and volumetric air flowrate per unit cooling capacity have been investigated. It is found that amongst ventilation, recirculation and Dunkle cycles, the Dunkle cycle is better for a wide range of outdoor conditions. However, cycles using wet surface heat exchangers give even higher performance.