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排序方式: 共有63条查询结果,搜索用时 515 毫秒
1.
Robert Bertuzzi 《岩石力学与岩土工程学报(英文版)》2019,11(3):494-510
This paper presents the results of ongoing research carried out by the author exploring methods to provide a more robust estimate of rock mass properties specifically for use in tunnel design. Data from various large-scale rock mass failures are introduced, including coal pillars. The damage-initiation,spalling-limit approach is compared to the coal pillar database. New comparisons of estimating the geological strength index(GSI) and relationships to estimate the Hoeke Brown failure criterion parameters, mb, s and a, are presented. 相似文献
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3.
Terenzio Bertuzzi Silvia Rastelli Annalisa Mulazzi Gianluca Donadini Amedeo Pietri 《Food Control》2011,22(12):2059-2064
The occurrence of ochratoxin A, trichothecenes, fumonisins and aflatoxins in a sample of 106 beers produced in several European countries, was investigated. The analyses were conducted using high-performance liquid chromatography with fluorimetric detection for ochratoxin A and aflatoxins, gas-chromatography and high-performance liquid chromatography, both coupled with mass spectrometer, for trichothecenes and fumonisins, respectively. Aflatoxins were not detected in any samples, whereas ochratoxin A, deoxynivalenol and fumonisins were found in a relatively high number of samples. Their presence was at low levels in all samples; however, some differences were observed between the European countries. As regards ochratoxin A, beer samples from southern Europe showed levels always lower than 0.040 μg l?1, while the samples from other European countries showed significantly higher values, up to 0.189 μg l?1 (P < 0.001). For fumonisins, the levels of Italian beers were significantly higher compared to the samples from other countries (P = 0.006). 相似文献
4.
The lithogenic character of human gallbladder bile was investigated by a mathematical model on the basis of a clinical data set. Each bile was described by means of the quaternary system bile salts--phospholipids--free fatty acids--cholesterol. Reporting a set of bile samples on the tetrahedron of concentrations, a clear separation emerged between the control bile, the bile from patients with gallstones, and the bile of subjects with gallbladder dyskinesia. This group was characterized by a largely increased content of free fatty acids. 相似文献
5.
Pietri A Gualla A Rastelli S Bertuzzi T 《Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment》2011,28(12):1717-1723
The extraction of ochratoxin A from meat products is generally carried out using chlorinated organic solvents, such as chloroform or methyl chloride, acidified with hydrochloric or o-phosphoric acid. In this study, an innovative method was developed to extract ochratoxin A from pork and dry-cured ham samples. The method was based on an enzyme-assisted extraction with pancreatin in phosphate buffer pH 7.5. Pancreatin hydrolyses the proteins, so that ochratoxin A, kept in the ionised form, is easily extracted by the aqueous solution. After purification through an immunoaffinity column, ochratoxin A is determined by HPLC with fluorescence detection. The average recovery values were higher than 90.0% and the relative standard deviations were below 5.5%. The limits of detection and of quantification were 0.06 and 0.12 μg kg(-1), respectively. A comparison between the new enzyme-assisted extraction and an established chloroform method was carried out on six naturally contaminated samples of pork and on 40 samples of dry-cured ham. Significantly higher (p<0.001) values of ochratoxin A were obtained on dry-cured ham samples by the enzyme-assisted method. 相似文献
6.
Galvano F Pietri A Bertuzzi T Gagliardi L Ciotti S Luisi S Bognanno M La Fauci L Iacopino AM Nigro F Li Volti G Vanella L Giammanco G Tina GL Gazzolo D 《Molecular nutrition & food research》2008,52(4):496-501
During 2006, 82 samples of human mature milk were collected at Italian hospitals and checked for aflatoxin M1 (AFM1) and ochratoxin A (OTA) by immunoaffinity column extraction and HPLC. AFM1 was detected in four (5%) of milk samples (ranging from < 7 ng/L to 140 ng/L; mean level: 55.35 ng/L); OTA was detected in 61 (74%) of milk samples (ranging from < 5 ng/L to 405 ng/L; mean level: 30.43 ng/L. OTA levels were significantly higher (p less, not double equals 0.05) in milk of habitual consumers of bread, bakery products and cured pork meat. No other statistically significant differences were observed although habitual consumers of pasta (p = 0.059), cookies (p = 0.061) and juices (p = 0.063) had mean contamination values of OTA higher than the moderate consumer. The very few AFB1 positive samples did not allow statistical comparisons. The present study confirms that the occurrence of OTA in human milk is related to maternal dietary habits. The findings support the possibility of dietary recommendations to woman, during pregnancy and lactation, aimed to tentatively reduce the OTA contamination of human milk. 相似文献
7.
Jakob Olofsson Riccardo Cenni Matteo Cova Giacomo Bertuzzi Kent Salomonsson Joel Johansson 《Structural and Multidisciplinary Optimization》2018,57(5):1889-1903
During the casting process and solidification of ductile iron castings, a heterogeneous microstructure is formed throughout the casting. This distribution is strongly influenced by the item geometry and the process related factors, as chemical composition and local solidification conditions. Geometrical changes to the geometry of the casting thus alters the local mechanical behavior and properties, as well as the distribution of stresses and strains when the casting is subjected to load. In order to find an optimal geometry, e.g. with reduced weight and increased load-bearing capacity, this interdependency between geometry and local material behavior needs to be considered and integrated into the optimization method. In this contribution, recent developments in the multidisciplinary integration of casting process simulation, solidification and microstructure modelling, microstructure-based material characterization, finite element structural analyses with local material behavior and structural optimization techniques are presented and discussed. The effect and relevance of considering the local material behavior in shape optimization of ductile iron castings is discussed and evidenced by an industrial application. It is shown that by adopting a multidisciplinary optimization approach by integration of casting simulation and local material behavior into shape optimization, the potential of the casting process to obtain components with high performance and reliability can be enabled and utilized. 相似文献
8.
Quinone‐Fused Pyrazoles through 1,3‐Dipolar Cycloadditions: Synthesis of Tricyclic Scaffolds and in vitro Cytotoxic Activity Evaluation on Glioblastoma Cancer Cells 下载免费PDF全文
Giulio Bertuzzi Simone Crotti Pierpaolo Calandro Bianca Flavia Bonini Ilaria Monaco Erica Locatelli Mariafrancesca Fochi Paolo Zani Elena Strocchi Prof. Andrea Mazzanti Dr. Mario Chiariello Prof. Mauro Comes Franchini 《ChemMedChem》2018,13(17):1744-1750
A novel and straightforward synthesis of highly substituted isoquinoline‐5,8‐dione fused tricyclic pyrazoles is reported. The key step of the synthetic sequence is a regioselective, Ag2CO3 promoted, 1,3‐dipolar cycloaddition of C‐heteroaryl‐N‐aryl nitrilimines and substituted isoquinoline‐5,8‐diones. The broad functional group tolerability and mild reaction conditions were found to be suitable for the preparation of a small library of compounds. These scaffolds were designed to interact with multiple biological residues, and two of them, after brief synthetic elaborations, were analyzed by molecular docking studies as potential anticancer drugs. In vitro studies confirmed the potent anticancer effects, showing promising IC50 values as low as 2.5 μm against three different glioblastoma cell lines. Their cytotoxic activity was finally positively correlated to their ability to inhibit PI3K/mTOR kinases, which are responsible for the regulation of diverse cellular processes in human cancer cells. 相似文献
9.
Battilani P Giorni P Bertuzzi T Formenti S Pietri A 《International journal of food microbiology》2006,111(Z1):S53-S60
The objective of this research was to investigate the presence of black aspergilli in grapes grown in Italy and to study the effect of environmental and cultural factors able to influence fungal incidence and ochratoxin A (OTA) presence. In this 3-year study, black aspergilli were frequently associated with grape berries; they were present in bunches starting from setting, colonising most berries at early veraison. Aspergillus carbonarius was never dominant at the different growth stages, or in different geographic areas and years, but it was confirmed as the key fungus because of the high percentage of strong OTA producer isolates in the population. The number of OTA producer strains, isolated in each vineyard at the different growth stages, was generally very limited and they were never statistically correlated to OTA content in bunches. The effect of geographic area on fungal flora was confirmed by statistical analysis, even though a major role was played by meteorological conditions, both on fungal colonisation and OTA content in bunches. Discriminant analysis gave promising perspectives for predicting OTA presence in vineyards in the future, based on summation of degree-day and rain in the period between 21st of August and 10th of September. 相似文献
10.
The control of lichen growth, particularly important in the field of stone conservation of outdoor monuments, largely depends on the use of biocides, that may be dangerous for the users, the environment and the substratum. A new, alternative approach is proposed, which makes the most of a poorly known peculiarity of poikilohydrous organisms: they are thermo-tolerant (up to 65-70 °C) when dry, but thermo-sensitive when wet. The efficacy of thermal treatments (range: 20-55 °C), in parallel to the application of three biocides, was verified in the laboratory with six epi- and endolithic lichens. Chlorophyll a fluorescence emission was checked in treated and nontreated samples of all the species, whereas histochemical observations with a dead cell stain were carried out on one of them. The feasibility of the thermal treatments in the field was verified with a seventh species. The results confirm that a 6 h treatment at 55 °C is sufficient to kill the lichens if they are kept fully hydrated. At 40 °C the organisms are damaged: in this case biocides at concentrations 10× lower than in normal applications can profitably be used. The new protocol is simple, the field equipment cheap, and the negative effects associated with standard biocide treatments are absent. 相似文献