全文获取类型
收费全文 | 1144篇 |
免费 | 32篇 |
国内免费 | 3篇 |
专业分类
电工技术 | 40篇 |
综合类 | 3篇 |
化学工业 | 236篇 |
金属工艺 | 28篇 |
机械仪表 | 29篇 |
建筑科学 | 15篇 |
能源动力 | 34篇 |
轻工业 | 105篇 |
水利工程 | 2篇 |
石油天然气 | 1篇 |
无线电 | 92篇 |
一般工业技术 | 190篇 |
冶金工业 | 269篇 |
原子能技术 | 44篇 |
自动化技术 | 91篇 |
出版年
2023年 | 4篇 |
2022年 | 19篇 |
2021年 | 25篇 |
2020年 | 14篇 |
2019年 | 6篇 |
2018年 | 18篇 |
2017年 | 12篇 |
2016年 | 26篇 |
2015年 | 14篇 |
2014年 | 31篇 |
2013年 | 59篇 |
2012年 | 58篇 |
2011年 | 57篇 |
2010年 | 38篇 |
2009年 | 50篇 |
2008年 | 47篇 |
2007年 | 33篇 |
2006年 | 18篇 |
2005年 | 27篇 |
2004年 | 29篇 |
2003年 | 33篇 |
2002年 | 39篇 |
2001年 | 20篇 |
2000年 | 17篇 |
1999年 | 27篇 |
1998年 | 127篇 |
1997年 | 68篇 |
1996年 | 45篇 |
1995年 | 28篇 |
1994年 | 26篇 |
1993年 | 26篇 |
1992年 | 13篇 |
1991年 | 13篇 |
1990年 | 8篇 |
1989年 | 8篇 |
1988年 | 16篇 |
1987年 | 9篇 |
1986年 | 7篇 |
1985年 | 7篇 |
1984年 | 10篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 4篇 |
1980年 | 3篇 |
1979年 | 9篇 |
1978年 | 5篇 |
1977年 | 2篇 |
1976年 | 9篇 |
1973年 | 3篇 |
1967年 | 2篇 |
排序方式: 共有1179条查询结果,搜索用时 15 毫秒
1.
Hideaki Kaneto Tomohiko Kimura Atsushi Obata Masashi Shimoda Kohei Kaku 《International journal of molecular sciences》2021,22(5)
While there are various kinds of drugs for type 2 diabetes mellitus at present, in this review article, we focus on metformin which is an insulin sensitizer and is often used as a first-choice drug worldwide. Metformin mainly activates adenosine monophosphate-activated protein kinase (AMPK) in the liver which leads to suppression of fatty acid synthesis and gluconeogenesis. Metformin activates AMPK in skeletal muscle as well, which increases translocation of glucose transporter 4 to the cell membrane and thereby increases glucose uptake. Further, metformin suppresses glucagon signaling in the liver by suppressing adenylate cyclase which leads to suppression of gluconeogenesis. In addition, metformin reduces autophagy failure observed in pancreatic β-cells under diabetic conditions. Furthermore, it is known that metformin alters the gut microbiome and facilitates the transport of glucose from the circulation into excrement. It is also known that metformin reduces food intake and lowers body weight by increasing circulating levels of the peptide hormone growth/differentiation factor 15 (GDF15). Furthermore, much attention has been drawn to the fact that the frequency of various cancers is lower in subjects taking metformin. Metformin suppresses the mechanistic target of rapamycin (mTOR) by activating AMPK in pre-neoplastic cells, which leads to suppression of cell growth and an increase in apoptosis in pre-neoplastic cells. It has been shown recently that metformin consumption potentially influences the mortality in patients with type 2 diabetes mellitus and coronavirus infectious disease (COVID-19). Taken together, metformin is an old drug, but multifaceted mechanisms of action of metformin have been unraveled one after another in its long history. 相似文献
2.
Naoki Yokokawa Yutaro Masuda Eri Amasawa Hirokazu Sugiyama Masahiko Hirao 《Packaging Technology and Science》2020,33(11):445-459
This study presents systematic packaging design tools integrating functional and environmental consequences on product life cycle. To design packaging for sustainability, the trade-offs between functional and environmental aspects of packaging throughout the product life cycle should be considered. However, it is difficult for packaging designers to understand the overall trade-offs because the extent of the design consequences on the entire life cycle of packaging and its contents is unclear. We developed two tools for packaging design: the Life Cycle Association Matrix (LCAM) and the Function Network Diagram (FND). The following three steps, based on literature reviews and interviews with industrial experts, were applied. Firstly, we listed the product functions and design variables related to the functions as the attributes allocated to the product life cycle. Secondly, the attributes were connected appropriately based on causal relationships. Lastly, we identified the factors to support decision making in the packaging design procedure. As a result, the LCAM depicts the design consequences on the life cycle, and the FND determines the stakeholders affected by the design consequences. Two case studies were demonstrated to analyze the trade-offs by using our tools. In the case studies, a liquid laundry detergent bottle and a milk carton were redesigned. The tools identified the design consequences and stakeholders affected by the redesign of the usability and protective function for the detergent and milk cases, respectively. The results showed the significance of understanding the design consequences on the product life cycle by integrating the functional and environmental aspects. 相似文献
3.
Machine Learning - We consider the problem of learning a binary classifier from only positive and unlabeled observations (called PU learning). Recent studies in PU learning have shown superior... 相似文献
4.
A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts 下载免费PDF全文
5.
Mitsuo Miyazawa Tomohiko Takahashi Kazuki Sakata Isao Horibe 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2008,83(7):1006-1011
BACKGROUND: The biotransformation of sesquiterpenoids, which are a large class of naturally occurring compounds, using microorganisms as a biocatalyst to produce useful novel organic compounds was investigated. The biotransformation of sesquiterpenoids, (+)‐aromadendrene ( 1 ), (−)‐alloaromadendrene ( 2 ) and (+)‐ledene ( 3 ) has been investigated using Aspergillus wentii as a biocatalyst. Results: Compound 1 was converted to (−)‐(10S,11S)‐10,13,14‐trihydroxyaromadendrane ( 4 ). Compound 2 was converted to (+)‐(1S,11S)‐1,13‐dihydroxyaromadendrene ( 5 ) and (−)‐5,11‐epoxycadin‐1(10)‐en‐14‐ol ( 6 ). Compound 3 was converted to compound 6 , (+)‐(10R,11S)‐10,13‐dihydroxyaromadendr‐1‐ene ( 7 ) and (+)‐(10S,11S)‐10,13‐dihydroxyaromadendr‐1‐ene ( 8 ). The structure of the metabolic products has been elucidated on the basis of their spectral data. CONCLUSION: Compound 1 gave only one product that was hydroxylated at C‐10, C‐13 and C‐14. By contrast, compounds 2 and 3 gave a number of products, one of which was common. The differences in oxidation of 1–3 are due to the configuration of the C‐1 position. Compounds 4–8 were new compounds. Copyright © 2008 Society of Chemical Industry 相似文献
6.
K. Fujii J. Fujimoto H. Hayashii R. Kajikawa Y. Masatani H. Ozaki A. Sugiyama R. Suzaki S. Suzuki T.Y. Tsukamoto T.F. Tsukamoto S. Uno S. Iwata 《Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment》1985,236(1):55-63
We constructed and tested a prototype gas sampling electromagnetic calorimeter of the Pb-proportional tube sandwich type. The calorimeter uses conductive plastic tubes and cathode pad readout with a tower structure which resulted in reasonable energy and spatial resolutions for electrons in the momentum range 0.5–4.0 GeV/c; /c). This paper describes the test and the performance studied under various conditions. 相似文献
7.
[110]-surface strained-SOI CMOS devices 总被引:1,自引:0,他引:1
Mizuno T. Sugiyama N. Tezuka T. Moriyama Y. Nakaharai S. Takagi S. 《Electron Devices, IEEE Transactions on》2005,52(3):367-374
We have newly developed [110]-surface strained-silicon-on-insulator (SOI) n- and p-MOSFETs on [110]-surface relaxed-SiGe-on-insulator substrates with the Ge content of 25%, fabricated by applying the Ge condensation technique to SiGe layers grown on [110]-surface SOI wafers. We have demonstrated that the electron and the hole mobility enhancement of [110]-surface strained-SOI devices amounts to 23% and 50%, respectively, against the mobilities of [110]-surface unstrained MOSFETs. As a result, the electron and the hole mobility ratios of [110]-surface strained-SOI MOSFETs to the universal mobility of (100)-surface bulk-MOSFETs increase up to 81% and 203%, respectively. Therefore, the current drive imbalance between n- and p-MOS can be reduced. Moreover, both the electron and the hole mobilities of the [110]-surface strained-SOIs strongly depend on the drain current flow direction, which is qualitatively explained by the anisotropic effective mass characteristics of the carriers on a [110]-surface Si. As a result, the [110]-surface strained-SOI technology with optimization of the current flow directions of n- and p-MOS is promising for realizing higher speed scaled CMOS. 相似文献
8.
We succeeded in the fabrication of bonded laser crystals composed of a neodymium-doped YVO4 laser crystal (Nd:YVO4) and its host crystals YVO4 by a newly developed dry etching technique using an argon ion beam. The optical distortion caused by the bonded interface of size 5 mm × 6 mm was estimated to be 0.05λ at 633 nm. From the comparison of laser performance pumped by a laser diode, the bonded crystals could increase the laser output power by nearly twice that of the non-bonded crystals with the same degree of polarization of 99.2%. To analyze the mechanism of the enhanced reduction of the thermal load in the bonded crystals, numerical simulations with a finite-element method were also performed. 相似文献
9.
10.
En-Hai Sun Yong-Ho Choa Tohru Sekino Tomohiko Adachi Koichi Niihara 《Materials Research Innovations》2002,6(3):105-111
Cordierite/ZrO2 composites with 5 to 25 wt% ZrO2 were fabricated by conventional powder mixing and pressureless sintering method. Their densification behavior, microstructure,
mechanical and thermal properties were studied. By dispersing 25 wt% (9.57 vol%) ZrO2, densified cordierite/ZrO2 composite with a relative density of 98.5% was obtained at an optimum sintering condition of 1440 °C and 2 h. ZrO2 particles were homogenously dispersed within matrix grains and at the grain boundaries. The intragranular particles were
finer than 100 nm and the intergranular particles were coarser. Both fracture strength and toughness could be enhanced more
than two times higher, compare to those of monolithic cordierite, by dispersing 25 wt% ZrO2 into the cordierite matrix. The toughening mechanism in the present composites was mainly attributed to martensitic transformation
due to ZrO2 dispersion.
Electronic Publication 相似文献