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排序方式: 共有77条查询结果,搜索用时 15 毫秒
1.
F Sanae S Ohmae M Kurita H Sawanishi K Takagi K Miyamoto 《Canadian Metallurgical Quarterly》1995,69(2):75-82
Relationships between the alkyl substitutions (C1-C6) and cardiac inotropic activities of xanthine derivatives were studied in isolated guinea pig heart muscles. Most of the alkylxanthines exhibited positive inotropic activity on the left atrium, which was increased with an elongation of alkyl chain at the N3-position but decreased by substitution of a long alkyl group at the N1- or N7-position of the xanthine skeleton. Although positive inotropic activity in the right ventricular papillary muscle was also increased by longer alkyl groups at the N3-position, the inotropic activity became negative with an increment in alkyl chain length at the N1- or N7-position. The positive inotropic activity of alkylxanthines was correlated with their inhibitory activity on the phosphodiesterase (PDE) III isoenzyme. Adenosine A1 antagonism and PDE IV inhibitory activity were also partly associated with the inotropic activity because H-89, an inhibitor of cyclic AMP-dependent protein kinase, diminished the positive inotropic action and potentiated the negative inotropic action. These results indicate that the positive inotropic activity of alkylxanthines becomes weak with elongation of alkyl chains at the N1- and N7-positions; In particular, xanthines having two long alkyl chains show a negative inotropic activity on the right ventricular papillary muscle, an effect that could not be elucidated from their cyclic AMP-dependent action. 相似文献
2.
Yasushi Endo Sanae Hoshizaki Kenshiro Fujimoto 《Journal of the American Oil Chemists' Society》1997,74(9):1041-1045
Thirteen synthetic triacylglycerols (TAG) containing eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) were oxidized
in the presence of 2,2′-azobis(2,4-dimethyl-valeronitrile) (AMVN) and 2,2′-azobis(2-amidinopropane)dihydrochloride (AAPH)
as aqueous and nonaqueous radical initiators to investigate the influence of TAG structure and oxidation system on the oxidative
stability of TAG that contain highly unsaturated fatty acids (HUFA). A 2:1 (mol/mol) mixture of trieicosapentaenoylglycerol
and tripalmitoylglycerol was most susceptible to the AMVN-initiated oxidation among three types of TAG that contained EPA
and palmitic acid (2:1, mol/mol). Compared with 1,2 (or 2,3)-dieicosapentaenoyl-3(or 1)-palmitoylglycerol (EEP) and 1,3-dieicosapentaenoyl-2-palmitoylglycerol
(EPE), the oxidative rate of EEP was somewhat higher. A similar result was obtained for DHA-containing TAG. The oxidative
rate of TAG that contained EPA and palmitic acid (1:2, mol/mol) showed a positive correlation with the amount of EPA in a
single TAG molecule. Moreover, in the nonaqueous system, the oxidative rate of EPA-containing TAG was affected by unsaturation
and carbon chainlength of constituent fatty acids. In the AAPH-initiated oxidation in the aqueous system, the oxidative rate
of TAG with EPA and palmitic acid was higher with the increased quantity of EPA in a single TAG molecule. Also, constituent
fatty acids modified the oxidative rate of EPA-containing TAG in an aqueous system. The glycerol position of EPA and DHA also
affected the oxidative rate of the TAG. EPA and DHA located at the 1,2 (or 2,3)-position of glycerol were more oxidizable
than those at the 1,3-position during AAPH-initiated oxidation. Thus, 1,2(or2,3)-dipalmitoyl-3(or 1)-eicosapentaenoylglycerol
was oxidized faster than 1,3-dipalmitoyl-2-eicosapentaenoylglycerol. These observations suggest that the oxidative stability
of TAG that contain HUFA could be modulated by the oxidation system and TAG structure. 相似文献
3.
Sanae Dahbi Abdelhak Aziz Abdelhafid Messaoudi Imane Mazozi Kamal Kassmi Naima Benazzi 《International Journal of Hydrogen Energy》2018,43(10):5283-5299
In this article, the authors design a new clean storage device for a photovoltaic system (PV) reinforced by the electrical grid. The photovoltaic system supplies power to a DC load. When the power of the photovoltaic source is insufficient, the electrical grid compensates the energy deficit. On the other hand, if the load is satisfied and the PV source is still able of supplying energy, the energy excess is diverted to an own storage unit materialized by an electrolysis which produces gaseous hydrogen by the process of electrolysis of water. The authors show that the quantity of hydrogen produced is proportional to the photovoltaic energy excess and also to the flow of water injected into the electrolysis. In this case, it is a question of designing an electrolysis with specific characteristics, which takes into account the quantity of energy excess and the flow of water injected into it. The authors abandon the idea of controlling the water flow by means of a pumping-electrovalve system, and initiate the idea of replacing the function of the pump by the action of gravity. The work focuses on the development of an electrolysis optimization approach using the water flow control in its alliance with the PV power excess which is also maximized. For an optimized use of the global system (load and electrolysis), the authors present an architecture based on energy-converting structures (DC/DC and AC/DC). In addition, to increase the reliability and safety of the system, the authors finish by developing a power management strategy (PMS) in the designed system. This power management strategy organizes the energy flow and selects the appropriate path of this flow between the two energy sources (PV and electrical grid) and the two possible energy receivers (load and electrolysis). A complete modeling of the system is developed in the Matlab/Simulink environment. The simulation results show that the hybrid system (PV and electrical grid) is able to permanently supplying the load and potentially storing the excess of the PV energy in the form of hydrogen gas. 相似文献
4.
5.
Nagayama T Takano I Kobayashi M Tamura Y Tomizawa S Tateishi Y Kimura N Kitayama K Saito K 《Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan》2003,44(2):126-131
A simple and rapid method is described for the determination of the non-registered pesticides, captafol, quintozene (PCNB), cyhexatin and 1-naphthylacetic acid (NAA), in fruits. These pesticides were extracted with acidified acetone, then captafol and PCNB were purified with a Florisil mini column and analyzed by GC-ECD. Cyhexatin was ethylated with ethylmagnesium bromide, and the ethyl derivative was analyzed by GC-FPD (Sn filter). NAA was purified with liquid-liquid extraction and determined by HPLC equipped with a fluorescence detector. These analytes were identified with GC/MS or LC/MS. The minimum identified concentration of the pesticides was below 0.2 ng per injection, which corresponds to a detection limit of below 0.02 microgram/g in the original samples. Recoveries of the pesticides spiked at 0.1 microgram/g into apple, Japanese pear and melon were greater than 61%. 相似文献
6.
Information on subcategorization and selectional restrictions in a valency dictionary is important for natural language processing
tasks such as monolingual parsing, accurate rule-based machine translation and automatic summarization. In this paper we present
an efficient method of assigning valency information and selectional restrictions to entries in a bilingual dictionary, based
on information in an existing valency dictionary. The method is based on two assumptions: words with similar meaning have
similar subcategorization frames and selectional restrictions; and words with the same translations have similar meanings.
Based on these assumptions, new valency entries are constructed for words in a plain bilingual dictionary, using entries with
similar source-language meaning and the same target-language translations. We evaluate the effects of various measures of
semantic similarity. 相似文献
7.
Hong Chen Ryozo Ooka Kazuo Iwamura Hong Huang Nobufusa Yoshizawa Kiyoshi Miisho Satoshi Yoshida Sanae Namatame Atsushi Sakakura Syunichi Tanaka 《Energy and Buildings》2008,40(5):782-792
“Distributed local energy systems” had been expected to rationalize the supply of energy to built-up areas, but until now very little research has been performed to estimate the effect of their application to actual cities. In this research, therefore, a future vision for the year 2030 in the Sancha Area (SANCHA VISION 2030), a typical densely built-up area in Tokyo, has been elaborated including a simulation to estimate benefits from the application of distributed energy systems in terms of reduced energy consumption and CO2 emissions as well as mitigation of the heat-island phenomenon. As a result, it was demonstrated that a “distributed local energy system”, which provides a district with both electrical power and heat through an integrated distribution system, may contribute to a considerable improvement in energy efficiency for those areas. In addition, it may also provide other benefits, including enhancement of living amenity and urban security in times of emergency. 相似文献
8.
Hameedullah Kazi Peter Haddawy Siriwan Suebnukarn 《Journal of Intelligent Information Systems》2013,41(2):269-284
Problem based learning is becoming widely popular as an effective teaching method in medical education. Paying individual attention to a small group of students in medical problem-based learning (PBL) can place burden on the workload of medical faculty whose time is very costly. Intelligent tutoring systems offer a cost effective alternative in helping to train the students, but they are typically prone to brittleness and the knowledge acquisition bottleneck. Existing tutoring systems accept a small set of approved solutions for each problem scenario stored into the system. Plausible student solutions that lie outside the scope of the explicitly encoded ones receive little acknowledgment from the system. Tutoring hints are also confined to the knowledge space of the approved solutions, leading to brittleness in the tutoring approach. We report the clinical reasoning gains off a tutoring system for medical PBL that employs and represents the widely available medical knowledge source UMLS as the domain ontology. We exploit the structure of the concept hierarchy to expand the plausible solution space and generate hints based on the problem solving context. Evaluation of student learning outcomes led to highly significant learning gains (Mann-Whitney, p < 0.001). 相似文献
9.
Sanae Shimizu Kazuhiko Yamamoto Caihau Wang Yutaka Satoh Hideki Tanahashi Yoshinori Niwa 《Electrical Engineering in Japan》2005,152(3):29-38
Moving object detection with a mobile image sensor is an important task in robotics and computer vision, when considering the practical use of robotics in human environments. In this paper, we propose a robust method that detects moving objects in the environment using the omnidirectional depth information obtained by a mobile Stereo Omnidirectional System (SOS). In order to detect only the moving objects within the depth image that are obtained by a sensor in motion, we first estimate the ego‐motion of the sensor, and generate a predicted depth image for the current time from the depth obtained at the previous time by only considering the ego‐motion of the sensor. Then the predicted depth image is compared with the actual one obtained at the current time, and the inconsistent regions are detected as moving objects. When the sensor moves, occlusions will occur in the scene and they will cause false detections. However, these false detections can be suppressed by estimating the occlusion regions using the ego‐motion parameters of the sensor and the jump edges in the depth image. The effectiveness of the method is shown with experimental results for a real environment. © 2005 Wiley Periodicals, Inc. Electr Eng Jpn, 152(3): 29–38, 2005; Published online in Wiley InterScience ( www.interscience. wiley.com ). DOI 10.1002/eej.20155 相似文献
10.
Takeo M Yasukawa T Abe Y Niihara S Maeda Y Negoro S 《Journal of Bioscience and Bioengineering》2003,95(2):139-145
A 4-nitrophenol (4-NP)-degrading bacterium was isolated from activated sludge and identified as a Rhodococcus sp. This bacterium, designated as strain PN1, could utilize 4-NP as a sole carbon, nitrogen and energy source. Degradation tests of 4-NP using cell suspensions of strain PN1 revealed that the degradation was induced by 4-NP and that 4-nitrocatechol (4-NC) was one of the metabolites. A gene library was constructed from the total DNA of strain PN1 and introduced into Rhodococcus rhodochrous ATCC 12674. Two recombinant strains showed 4-NP hydroxylase activity, and a 9.1-kb DNA fragment encoding the activity was isolated from one of the strains. In addition, a 2.4-kb smaller fragment expressing the activity was subcloned from the 9.1-kb fragment and sequenced. The sequence analysis showed that the fragment encodes a two-component 4-NP hydroxylase, the predicted amino acid sequence of which exhibits significant similarity to those of phenol hydroxylases and 4-hydroxyphenylacetate 3-hydroxylases belonging to the two-component flavin diffusible monooxygenase (TC-FDM) family proposed by Galán et al. (J. Bacteriol., 182, 627-636, 2000). 相似文献