Competition through selective inhibitory synchrony

Models of cortical neuronal circuits commonly depend on inhibitory feedback to control gain, provide signal normalization, and selectively amplify signals using winner-take-all (WTA) dynamics. Such models generally assume that excitatory and inhibitory neurons are able to interact easily because their axons and dendrites are colocalized in the same small volume. However, quantitative neuroanatomical studies of the dimensions of axonal and dendritic trees of neurons in the neocortex show that this colocalization assumption is not valid. In this letter, we describe a simple modification to the WTA circuit design that permits the effects of distributed inhibitory neurons to be coupled through synchronization, and so allows a single WTA to be distributed widely in cortical space, well beyond the arborization of any single inhibitory neuron and even across different cortical areas. We prove by nonlinear contraction analysis and demonstrate by simulation that distributed WTA subsystems combined by such inhibitory synchrony are inherently stable. We show analytically that synchronization is substantially faster than winner selection. This circuit mechanism allows networks of independent WTAs to fully or partially compete with other.     

“平面的科学性”:住宅建筑及其相关(1860-1930年)

通过研究英国现代住宅在19世纪下半叶以来的平面科学,本文展现出全景式的视角来认知当时的建筑师将住宅科学化的思想是如何成形的,并且认知相关的英国理论是如何与同时代的德国及法国理论发生关联的.从现代住宅的平面科学性出发,19世纪末至20世纪初年建筑理论中关于住宅特征与民族国家性的关系得到了在民族学、人类学、艺术史等学科视角之下的讨论.     

CLA isomers in milk fat from cows fed diets with high levels of unsaturated fatty acids

The concentrations of CLA isomers were determined by Ag⁺-HPLC in the milk fat of cows fed a control diet consisting of hay ad libitum and 15 kg of fodder beets or this diet supplemented with oilseeds containing either high levels of oleic acid (rapeseed), linoleic acid (sunflower seed), or α-linolenic acid (linseed). Highly significant (P≤0.001) correlations were found between the daily intakes of oleic acid and the concentration of the CLA isomer trans-7,cis-9 in milk fat; of linoleic acid and the CLA isomers trans-10,trans-12, trans-9,trans-11, trans-8,trans-10, trans-7,trans-9, trans-10,cis-12, cis-9,trans-11, trans-8,cis-10, and trans-7,cis-9; and of α-linolenic acid and the CLA isomers trans-12,trans-14, trans-11,trans-13, cis,trans/trans,cis-12,14, trans-11,cis-13, and cis-11,trans-13. CLA concentrations were also determined in the milk fat of cows grazing in the lowlands (600–650 m), the mountains (900–1210 m), and the highlands (1275–2120 m). The concentrations of many isomers were highest in milk fat from the highlands, but only three CLA isomers (cis-9,trans-11, trans-11,cis-13, and trans-8,cis-10) showed a nearly linear increase with elevation. Therefore, these three CLA isomers, and particularly the CLA isomer trans-11,cis-13, the second-most important CLA in milk fat from cows grazing at the three altitudes, could be useful indicators of milk products of Alpine origin.     

Phenotypic correlations among quality traits of fresh and dry-cured hams

In this study, fresh and processing quality traits were collected on a total of 312 Country Hams. Phenotypic correlations between traits were estimated and numerous values were significantly different (P<0.05) from zero. Yield was significantly correlated with several fresh pork quality traits measured on the fresh hams, including subjective color (0.34) and lipid percentage (0.32). Some meat color traits were significantly correlated, including associations between the color scores taken on the fresh and cured hams. Correlations between fresh pork quality traits were also determined, with results showing significant correlations between ultimate pH and other pork quality traits. The results indicate that yield can be maximized if hams with good fresh pork quality parameters are used for curing. The correlations estimates are helpful for understanding of the biological mechanisms behind the production of dry-cured hams and can potentially be used to improve the efficiency of the dry-cured ham production chain.     

A glow discharge unit to render electron microscope grids and other surfaces hydrophilic

We describe the design, construction, and operation of a simple glow discharge unit that can be used to make surfaces such as carbon-coated electron microscopy grids and glass coverslips hydrophilic. The use of a vacuum leak detector (Tesla coil) in place of a conventional high-voltage power supply and a small plastic desiccator for the vacuum chamber make the unit very inexpensive. Owing to the small volume of the chamber and the simplicity of the unit, the whole glow discharge process can be carried out in only 2 to 3 min, a time considerably shorter than that required for conventional vacuum evaporators. The hydrophilic surface improves adsorption of particles by several orders of magnitude in preparation for negative staining, freeze-drying, and other procedures.     

Potentiometric determination of the chloride ion activity in cement based materials

The chloride content at the reinforcement is one of the decisive factors for the initiation and propagation of localised corrosion in concrete structures. A monitoring technique for the chloride concentration which is accurate, non-destructive and continuous would thus be highly desirable. For this reason, the performance of ion selective electrodes (ISEs) was investigated both in alkaline solutions and embedded in mortar. The Ag/AgCl electrodes used in this work showed Nernstian behaviour with a slope of –59 ± 1 mV per decade and a detection limit for chloride ions below 10^?2 mol dm^?3 even at pH close to 14; the selectivity coefficient for hydroxide interference was estimated at \( k_{{{\text{Cl}}^{ - } ,{\text{OH}}^{ - } }}^{\text{pot}} \approx 4 \cdot 10^{ - 3} \). The Ag/AgCl membranes show good long-term stability over more than 6 months even in highly alkaline solutions as long as chloride ions are present; in the complete absence of chloride the measured potentials were affected by the pH of the solution. The sensors are, however, able to recover fast as soon as they come into contact with chloride. When using ISEs embedded in concrete, diffusion potentials between the reference electrode and the ISE, as arising e.g. from gradients in pH, significantly affect the potential measurement and present a most important error source for the application of direct potentiometry to concrete. To minimise such errors, the reference electrode has to be positioned as close to the ISE as possible.     

The graphite gauge and its application to the measurement of crack velocity

Existing methods for the measurement of crack position (and hence crack velocity) are briefly reviewed. Those methods are principally based on the optical, mechanical, electrical or acoustic behaviour of a cracking sample, or on an inspection of the fracture surfaces. None of the above techniques fulfills all conditions required to measure continually slow and fast crack growth in polymers up to 250°C, the only method capable of doing this is a potentiometric gauge without support. The development and application of such a graphite gauge to crack propagation in polymers is described in this paper. The experimental arrangement in general and the results obtained from “instrumented samples” in Charpy impact tests and from crack propagation across an interface between dissimilar materials are discussed and the advantages (large sensitivity, range of crack speeds from 10^?7 to 10³ m sec^?1) and disadvantages (gauge is also sensitive to plastic deformations) are indicated.     

Cladribine (2-CDA) given as subcutaneous bolus injections is active in pretreated Waldenstr?m's macroglobulinaemia. Swiss Group for Clinical Cancer Research (SAKK)

Clinical trials with intravenous cladribine infusions in pretreated patients with Waldenstr?m's macroglobulinaemia have shown a response rate of 40%. Our pharmacokinetic studies revealed that the bioavailability of subcutaneous cladribine is complete but that the concentration-time profile is very different from intravenous administration. We designed this phase II multi-institutional trial to study the activity and toxicity of cladribine given as s.c. bolus injections in patients with symptomatic Waldenstr?m's macroglobulinaemia. Between May 1993 and October 1995, 25 patients were accrued: male/female 18/7, median age 65 years (range 44-85). All except one patient had been pretreated with more than one regimen (median 2, range 0-10). 18 patients had progressed under previous therapy and six were in relapse. All patients received cladribine for a total dose of 0.5 mg/kg per cycle as s.c. bolus injections divided over 5 d at > or = 4 week intervals, for a maximum of six cycles. All 25 patients were evaluable for toxicity and response. A total of 67 cycles were administered (median 3 cycles, range 1-6). Overall response rate including disease stabilization which had been progressive under previous therapy was 68%. 10 patients (40%, 95% CI 21-61%) achieved a partial remission. Seven responders had been progressive under previous therapy. Maximum responses were reached no later than the third cycle. Median time to treatment failure and remission duration were 4.4 (range 0.5-33) and 8 months (5-29), respectively. Four patients (16%) suffered from infections W.H.O. grade > or = 2 (pneumonia grade 2, Staphylococcus septicaemia grade 3, viral encephalitis and pneumonia, both grade 4 with complete resolution). No other severe adverse events were observed. Cladribine given as s.c. 5 d bolus injections was found to be active in pretreated Waldenstr?m's macroglobulinaemia and resulted in durable remissions.     

Byzantine Agreement Given Partial Broadcast

This paper considers unconditionally secure protocols for reliable broadcast among a set of n players, where up to t of the players can be corrupted by a (Byzantine) adversary but the remaining h = n - t players remain honest. In the standard model with a complete, synchronous network of bilateral authenticated communication channels among the players, broadcast is achievable if and only if 2n/h < 3. We show that, by extending this model by the existence of partial broadcast channels among subsets of b players, global broadcast can be achieved if and only if the number h of honest players satisfies 2n/h < b + 1. Achievability is demonstrated by protocols with communication and computation complexities polynomial in the size of the network, i.e., in the number of partial broadcast channels. A respective characterization for the related consensus problem is also given.