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排序方式: 共有606条查询结果,搜索用时 15 毫秒
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Oxidative Stress Imaging: Visualizing Oxidative Cellular Stress Induced by Nanoparticles in the Subcytotoxic Range Using Fluorescence Lifetime Imaging (Small 23/2018) 下载免费PDF全文
4.
Graph constraints were introduced in the area of graph transformation, in connection with the notion of (negative) application conditions, as a form to limit the applicability of transformation rules. However, we believe that graph constraints may also play a significant role in the area of visual software modelling or in the specification and verification of semi-structured documents or websites (i.e. HTML or XML sets of documents). In this sense, after some discussion on these application areas, we concentrate on the problem of how to prove the consistency of specifications based on this kind of constraints. In particular, we present proof rules for two classes of graph constraints and show that our proof rules are sound and (refutationally) complete for each class. In addition, we study clause subsumption in this context as a form to speed up refutation. 相似文献
5.
Gadolinium-enhanced magnetic resonance angiography of the pelvis in patients with erectile impotence
Michael K. Stehling Libin Liu Gerhard Laub Kurt Fleischmann Ulrike Rohde 《Magma (New York, N.Y.)》1997,5(3):247-254
This study evaluted the potential of contrast-enhanced digital-subtraction magnetic resonance angiography (CE-DS-MRA) for
noninvasive angiographic delineation of the arterial supply of the penis in patients with erectile dysfunction. After induction
of an erection with prostaglandin E, a three-dimensional fast imaging with steady-state precision (FISP) sequence with TE
of 1.8–2 milliseconds, TR of 4.4–5 milliseconds, and flip angle of 40°–60° was used to obtain high-resolution angiograms of
the pelvis and penis during the injection of gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) 0.3 mmol/kg body weight,
within 30–50 seconds. DS maximum intensity projections (MIPs) and multiplanar reconstructions (MPRs) were compared with clinical
work-up and directional Doppler ultrasound in 11 patients. In all 11 patients (100%), the arterial supply of the penis could
be delineated from the aortic bifurcation via the iliac and internal pudendal arteries to the dorsal and deep penile arteries.
Of the 22 internal pudendal arteries, 6 (27%) were occluded on CE-DS-MRA and 5 (23%) had stenoses, of which 4 (18%) were greater
than 50%. In 7 patients (64%) good correlation between CE-DS-MRA and clinical findings and/or Doppler ultrasound was found;
in 2 patients (18%), the correlation was moderate, and in 2 patients (18%) results were discrepant. In 6 patients (55%), MRA
provided additional information to the clinical and Doppler ultrasound work-up. CE-DS-MRA can delineate small sessels such
as the internal pudendal and penile arteries and thus has the potential to become a noninvasive angiography method in the
work-up of erectile impotence.
Supported by Siemens Medical Systems, Erlangen; Schering AG, Berlin; and Agfa-Gevaert AG, Leverkusen. 相似文献
6.
Pia Fahlbusch Aleksandra Nikolic Sonja Hartwig Sylvia Jacob Ulrike Kettel Cornelia Kllmer Hadi Al-Hasani Stefan Lehr Dirk Müller-Wieland Birgit Knebel Jrg Kotzka 《International journal of molecular sciences》2022,23(12)
Alterations in mitochondrial function are an important control variable in the progression of metabolic dysfunction-associated fatty liver disease (MAFLD), while also noted by increased de novo lipogenesis (DNL) and hepatic insulin resistance. We hypothesized that the organization and function of a mitochondrial electron transport chain (ETC) in this pathologic condition is a consequence of shifted substrate availability. We addressed this question using a transgenic mouse model with increased hepatic insulin resistance and DNL due to constitutively active human SREBP-1c. The abundance of ETC complex subunits and components of key metabolic pathways are regulated in the liver of these animals. Further omics approaches combined with functional assays in isolated liver mitochondria and primary hepatocytes revealed that the SREBP-1c-forced fatty liver induced a substrate limitation for oxidative phosphorylation, inducing enhanced complex II activity. The observed increased expression of mitochondrial genes may have indicated a counteraction. In conclusion, a shift of available substrates directed toward activated DNL results in increased electron flows, mainly through complex II, to compensate for the increased energy demand of the cell. The reorganization of key compounds in energy metabolism observed in the SREBP-1c animal model might explain the initial increase in mitochondrial function observed in the early stages of human MAFLD. 相似文献
7.
Gen Li Ulrike K. Müller Johan L. van Leeuwen Hao Liu 《Journal of the Royal Society Interface》2014,11(101)
Fish larvae may intercept their own wake during sharp turns, which might affect their escape performance. We analysed C-starts of larval zebrafish (Danio rerio, Hamilton, 1822) using a computational fluid dynamics approach that simulates free swimming (swimming trajectory is determined by fluid forces) by coupling hydrodynamics and body dynamics. The simulations show that fish may intercept their own wake when they turn by 100–180°. During stage 1 of a C-start, the fish generates a strong jet at the tail that is shed into the wake. During stage 2, the fish intercepts this wake. Counterfactual simulations showed that wake interception increased the lateral force on the fish and reduced the fish''s turning angle by more than 5°. Wake interception caused no significant acceleration tangential to the trajectory of the fish and did not affect total power output. While experimental and simulation evidence suggests that fish larvae can either undershoot or intercept but not overshoot their wake, our simulations show that larger fish might be able to avoid intercepting their wake by either under- or overshooting. As intercepting its own wake modifies the fish''s escape trajectory, fish should account for this effect when planning their escape route. 相似文献
8.
Benjamin W. Riblett Nicola L. Francis Margaret A. Wheatley Ulrike G. K. Wegst 《Advanced functional materials》2012,22(23):4920-4923
Successful spinal cord repair is thought to be promoted with hierarchically structured scaffolds. These should combine aligned porosity with additional linear features on the micrometer scale to guide axons across multiple length scales. Such scaffolds are generated through the carefully controlled directional solidification of an aqueous biopolymer solution, followed by lyophilization. Under specific freezing conditions this yields a highly regular and aligned lamellar architecture. This architecture exhibits uniform ridges of controlled height and width on the lamellar surface. These ridges run parallel to the pore axis, serving as secondary guidance features. The ridges are capable of linearly aligning 62.4% of chick dorsal root ganglia neurites to within ±10° of the ridge direction. Notably, neurites sprouting perpendicular to the ridge are guided into alignment with these microridged features. 相似文献
9.
Christina Schwind Jürgen Buder Ulrike Cress Friedrich W. Hesse 《Computers & Education》2012,58(2):787-796
The Web is a perfect backdrop for opinion formation as a multitude of different opinions is publicly available. However, the different opinions often remain unexploited: Learners prefer preference-consistent over preference-inconsistent information, a phenomenon called confirmation bias. Two experiments were designed to test whether technologies such as recommender systems can be used to overcome this bias. The role of preference-inconsistent recommendations was explored by comparing their influence to a condition with preference-consistent recommendations and to a control condition without recommendations. In Study 1, preference-inconsistent recommendations led to a reduction of confirmation bias and to a more moderate view of the controversial topic of neuro-enhancement. In Study 2, we found that preference-inconsistent recommendations stimulated balanced recall and divergent thinking. Together these studies showed that preference-inconsistent recommendations are an effective approach for reducing confirmation bias and stimulating divergent thinking. In conclusion, future research and practical implications are discussed. 相似文献
10.
Christina Skiera Panagiotis Steliopoulos Thomas Kuballa Ulrike Holzgrabe Bernd Diehl 《Journal of the American Oil Chemists' Society》2012,89(8):1383-1391
Within the course of lipid peroxidation, hydroperoxides are formed as primary products. They can be used as analytical markers
to assess the deterioration status of oils and fats. Here a new 1H-NMR assay to determine the hydroperoxide amount in edible oils is presented. We were able to show that the analytical performance
of the method is similar to that of the commonly used peroxide value (PV) according to Wheeler. A total of 290 edible oil
samples were analyzed using both methods. For some oil varieties considerable discrepancies were found between the results
obtained. In the case of black seed and olive oil, two substances could be identified that cause positive (black seed oil)
and negative (olive oils) deviations from the theoretical PV expected from the NMR values. 相似文献