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排序方式: 共有266条查询结果,搜索用时 31 毫秒
1.
Marginal costs of electricity vary by time and location. In the past, researchers attributed the variations to factors related to electricity generation and transmission. These authors, however, have not analyzed possible variations in marginal distribution capacity costs (MDCC). The objectives of this paper are:
- 1. (i) to show that large MDCC variations are due to the dispersion in distribution capital expenditures by time and space,
- 2. (ii) to propose a method for quantifying the area- and time-specific MDCC in the presence of lumpy investments, and
- 3. (iii) to compare our MDCC estimates to those commonly used in the electric utility industry.
2.
Nitrification is a key step for reliable biological nitrogen removal. In order to enhance nitrification in the activated sludge (AS) process, membrane-attached biofilm (MAB) was incorporated in a conventional activated sludge tank. Simultaneous organic carbon removal and nitrification of the MAB incorporated activated sludge (AS + MAB) process was investigated with continuous wastewater treatment. The effluent TOC concentration of AS and the AS + MAB processes were about 6.3 mg/L and 7.9 mg/L, respectively. The TOC removal efficiency of both AS and AS + MAB were above 95% during the wastewater treatment, indicating excellent organic carbon removal performance in both processes. Little nitrification occurred in the AS process. On the contrary, successful nitrification was obtained with the AS + MAB process with nitrification efficiency of about 90%. The volumetric and surface nitrification rates were about 0.14 g/Ld and 6.5 g/m2d, respectively. The results clearly demonstrated that nitrification in the conventional AS process was boosted by MAB. Furthermore, the microfaunal population in the AS + MAB process was different from that in the AS process. The high concentration of rotifers in the AS + MAB process was expected to decrease the generation of excess sludge in the process. 相似文献
3.
We have previously shown that strychnine mimics the cytoprotective properties of glycine in renal proximal tubule (RPT) suspensions exposed to antimycin A (AA). The aims of this study were to determine whether the cytoprotective properties of strychnine applied to various types of nephrotoxicants and to examine the temporal aspects of the cytoprotection of glycine and strychnine. Tubular release of LDH activity was used as a marker of cell death. Glycine (2 mM) or strychnine (1 mM) added 5 min prior to the toxicant decreased LDH release in rabbit RPT suspensions exposed to 25 microM tetrafluoroethyl-L-cysteine (TFEC), 10 microM HgCl2, 0.5 mM t-butyl hydroperoxide (TBHP), or 0.2 mM bromohydroquinone (BHQ) for 4 hr, or 2 mM sodium cyanide (NaCN) for 2 hr. The relative rank order of effectiveness of glycine and strychnine was NaCN = TFEC > BHQ > DCVC > TBHP > HgCl2. The temporal aspects of strychnine and glycine protection were examined by exposing RPT to either AA or TFEC for 1 or 3 hr, respectively, and then adding either 1 mM glycine or 1 mM strychnine. Glycine and strychnine decreased LDH release in AA-treated RPT at 1.25 and 2 hr and TFEC-treated RPT at 4 hr. In addition, when RPT exposed to AA or TFEC and treated with strychnine or glycine were washed at either 1 or 4 hr, protection was eliminated at later time points. When glycine was added to RPT treated with either PCBC, TFEC, or DCVC 5 min prior to or 30, 60, 120, and 180 min following toxicant addition, LDH release was reduced at all time points. These results demonstrate that strychnine and glycine protect RPT from a variety of diverse nephrotoxicants, strychnine and glycine do not need to be present at the time of toxic insult, strychnine and glycine cytoprotection is reversible, and strychnine and glycine act in the late phase of necrotic cell injury. 相似文献
4.
Y Nakamura Y Horii T Nishino H Shiiki Y Sakaguchi T Kagoshima K Dohi Z Makita H Vlassara R Bucala 《Canadian Metallurgical Quarterly》1993,143(6):1649-1656
Advanced glycosylation end products (AGEs) accumulate on long-lived extracellular matrix proteins and have been implicated in the micro- and macrovascular complications of diabetes mellitus. Within the arterial wall, AGE-modified proteins increase vascular permeability, inactivate nitric oxide activity, and induce the release of growth-promoting cytokines. Recently developed anti-AGE antibodies were used in an immunohistochemical analysis of coronary arteries obtained from type II diabetic and nondiabetic patients. High levels of AGE reactivity were observed within the atherosclerotic plaque present in vessels from selected patients with diabetes. Considered together with the pathological effects of AGEs on vascular wall homeostasis, these data support the role of advanced glycosylation in the rapidly progressive atherosclerosis associated with diabetes mellitus. 相似文献
5.
Summary CP/DD/MASS 13C-NMR spectra have been obtained for regenerated cellulose samples with different crystallinities as well as for cotton, -D-glucose, -D-cellobiose, and cellopentaose. The spectra of the regenerated cellulose samples exhibit broad multiplicities of the C-4 and C-6 resonance lines in a similar manner as those of native cellulose samples such as cotton and ramie, and, in addition, another broad tailing of the C-1 resonance. Since these multiplicities change linearly with crystallinity, it is concluded that they are ascribed to the contributions from the crystalline and noncrystalline components. Effects of hydrogen bonds and conformations of the -1,4-glycosidic linkage on the chemical shifts are also discussed. 相似文献
6.
Prediction of the biologically active sites in eclosion hormone from the silkworm, Bombyx mori 总被引:1,自引:0,他引:1
Kikuchi T; Okamoto M; Geiser M; Schmitz A; Gohda K; Takai M; Morita T; Horii K; Fujita N 《Protein engineering, design & selection : PEDS》1997,10(3):217-222
The structure-activity relationship of eclosion hormone from the silkworm,
Bombyx mori, was analyzed. First, the probable active residues in silkworm
eclosion hormone and also tobacco hornworm eclosion hormone were predicted
by the average distance map method. To examine the contributions of those
residues to the activity of silkworm eclosion hormone, Gly-substituted
mutants for those predicted residues were produced by site-directed
mutagenesis and their activities were evaluated by a bioassay. Finally,
Glu12, Met24 and Phe25 were estimated to be the crucial residues for the
eclosion hormone activity. The possibility of the development of a blocker
of an eclosion hormone receptor on the basis of the present work is also
discussed.
相似文献
7.
It has been said that nuclear energy is an important option for especially developing countries to satisfy their increasing energy demand. However, it will be difficult to deploy first of a kind nuclear power plant in developing countries because extensive safety demonstration has to be conducted in industrialized countries. On the other hand, it will be essential to present rigid proof of reliable operational experience to develop proper understanding of the safety features of new reactor systems among the people around the demonstration plant sites. One of the ways to solve the issue is to integrate existing technologies supported by a great deal of data and experience into a new reactor design. Based on the consideration, a small-sized district heating reactor system based on the pressurized water reactor (PWR) technologies combined with the fuel concept of high temperature gas cooled reactors (HTGRs) has been studied. The purpose of the combination of these two existing concepts is to take the best advantages of both excellent operational experience of PWRs and the integrity of HTGR fuel, coated particle fuel, against fission products release even at high temperature. We expect that this approach will help create a breakthrough to the current stagnation of nuclear power deployment. 相似文献
8.
Tolulope Peter Saliu Nao Yazawa Kotaro Hashimoto Kenshu Miyata Ayane Kudo Mayu Horii Mion Kamesawa Thanutchaporn Kumrungsee Noriyuki Yanaka 《International journal of molecular sciences》2022,23(2)
The early detection of diabetic nephropathy (DN) in mice is necessary for the development of drugs and functional foods. The purpose of this study was to identify genes that are significantly upregulated in the early stage of DN progression and develop a novel model to non-invasively monitor disease progression within living animals using in vivo imaging technology. Streptozotocin (STZ) treatment has been widely used as a DN model; however, it also exhibits direct cytotoxicity to the kidneys. As it is important to distinguish between DN-related and STZ-induced nephropathy, in this study, we compared renal responses induced by the diabetic milieu with two types of STZ models: multiple low-dose STZ injections with a high-fat diet and two moderate-dose STZ injections to induce DN. We found 221 genes whose expression was significantly altered during DN development in both models and identified serum amyloid A3 (Saa3) as a candidate gene. Next, we applied the Saa3 promoter-driven luciferase reporter (Saa3-promoter luc mice) to these two STZ models and performed in vivo bioluminescent imaging to monitor the progression of renal pathology. In this study, to further exclude the possibility that the in vivo bioluminescence signal is related to renal cytotoxicity by STZ treatment, we injected insulin into Saa3-promoter luc mice and showed that insulin treatment could downregulate renal inflammatory responses with a decreased signal intensity of in vivo bioluminescence imaging. These results strongly suggest that Saa3 promoter activity is a potent non-invasive indicator that can be used to monitor DN progression and explore therapeutic agents and functional foods. 相似文献
9.
Contrasting effects of water-soluble and water-insoluble dietary fibers on bile acid conjugation and taurine metabolism in the rat 总被引:2,自引:0,他引:2
The effect of the type of dietary fiber on the bile acid and taurine metabolism was examined in rats. Diets containing 10%
of various water-soluble fibers (citrus pectin, konjak mannan, guar gum) as compared to a fiber-free diet increased biliary
excretion of total bile acids. In contrast, water-insoluble dietary fibers (cellulose, corn bran, chitin; 10% in the diets)
as well as cholestyramine (5% in the diet) considerably, decreased bile acid excretion. Water-soluble dietary fibermediated
increases in bile acid excretion were totally attributable to increases in glycine-conjugates. Thus, these fibers greatly
increased by the bile acid glycine-to-taurine ratio (G/T). Excretio of glycine conjugates decreased more than that of taurine
conjugates in rats fed various water-insoluble dietary fibers. As a results, G/T in rats fed water-insoluble fibers was significantly
lowered as compared to G/T in animals fed a fiber-free diet. Cholestyramine did not affect the G/T ratio of bile acids. Fecal
bile acid excretion and the activities of hepatic cholesterol 7α-hydroxylase (EC 1.14.13.17) in rats fed various water-soluble
dietary fibers approximately doubled as compared to the respective values for rats fed a fiber-free diet. Whereas cholestyramine
greatly increased these parameters, water-insoluble fibers did not significantly affect them. Various water-soluble fibers
decreased hepatic concentration and urinary excretion of taurine as well as the activity of hepatic cysteine dioxygenase (EC
1.13.11.20). In contrast, water-insoluble fibers considerably increased hepatic taurine concentrations and enzyme activities.
The parameters for taurine metabolism were unaffected by cholestyramine. It was suggested that the types of dietary fiber
affected hepatic taurine synthesis and thus modified bile acid glycine/taurine ratios. 相似文献
10.
Retention of the stationary phase of aqueous–aqueous polymer phase systems is improved by a spiral column configuration which utilizes the radially acting centrifugal force along the spiral pitch to retain the heavier phase in the outer portion and the lighter phase in the inner portion of the spiral channel. For the separation of proteins which has low mass transfer rates, the system needs further modification of the separation channel to interrupt the laminar flow and enhance mixing of the two phases. 相似文献