The effect of long term use of amiodarone hydrochloride on time and frequency domain parameters of signal averaged electrocardiogram in patients with ischemia heart disease

The aim of this study was to assess the influence of amiodarone hydrochloride on time- and frequency-domain parameters of signal-averaged electrocardiogram (SAECG) in patients with ischaemic heart disease (IHD). The study population consisted of 33 patients (18 female and 15 male), mean age 59.2 +/- 7.7. Amiodarone hydrochloride was orally used in the initial dose 600 mg/day for 10 days, and subsequently 200 mg/days for 6 weeks. Recording of SAECG and ambulatory Holter monitoring were made at baseline and in 10 day and after 6 weeks of therapy. The following time-domain parameters were analyzed: the root mean square voltage of the last 40 and 50 ms of the filtered QRS (RMS40 i RMS50), total time duration of filtered QRS (t-QRS) and duration of low amplitude signals < 40 microV in the terminal part of QRS (LPD). Late potentials (LP) were recognized when at least two from three criteria were fulfilled: 1) RMS40 < 20 microV, 2) t-QRS > 114 ms, 3) LPD > 38 ms. Frequency analysis of SAECG allowed to calculate the following parameters in logarithmic scale: energy spectrum > -60 dB (A) and decibel drop at 40Hz (Dd) and also in linear scale: area ratio 20-50/0-20Hz (Ar) and magnitude ratio (MR1-7). The values of RMS40 and RMS50 did not significantly change during amiodarone therapy. The obtained values of t-QRS were significantly longer after antiarrhythmic therapy, respectively 97.8 +/- 9.1 ms at the baseline, 102.1 +/- 10 ms after 10 days (p < 0.05), and 104.1 +/- 10.4 ms after 6 weeks (p < 0.005). Moreover the values of LPD did not significantly change after amiodarone treatment. At the baseline the presence of LP were observed in 3 (9%), after 10 days were recorded in 8 (24%), and after 6 weeks in 7 (22%) cases. Only in one case the LP were observed during the whole antiarrhythmic therapy. Moreover, amiodarone hydrochloride did not statistically significant change frequency-domain parameters in logarithmic scale and in linear scale.     

Improvements and complications involved with adding an 85-GHzchannel to cloud liquid water radiometers

The improvement in cloud-liquid estimates by a microwave radiometer with the addition of measurements at 85 GHz is quantified. Atmospheric emission is simulated from radiosonde data at frequencies commonly used by ground-based water-vapor radiometers (22.235 and 31.65 GHz) and also at 85.5 GHz. Retrieval algorithms are developed from opacities based on full Mie extinction by cloud droplets and under an assumption that ice effects are not significant for downwelling emission. The algorithms use either three frequencies or only the lower two. The inclusion of 85-GHz information significantly improves liquid-water path estimates at all levels of integrated liquid water. The Rayleigh approximation is shown to be valid for most cloudy conditions. Uncertainty in the calculated opacities due to varying cloud droplet-size distributions and liquid-water content profiles is quantified. The accuracy of a retrieval algorithm trained by Rayleigh approximation opacities and including the additional uncertainty is shown to provide estimates with error levels similar to those from the algorithm trained with full Mie opacities     

Changes in smoking prevalence in Russia, 1996-2004

Objectives

In Russia, smoking prevalence has historically been high in men and relatively low in women. Female smoking prevalence is predicted to rise but assessment of changes has been limited by the lack of comparable data. Changes in the prevalence of smoking in Russia between 1996 and 2004, and whether theses changes differed by sociodemographic groups, were investigated.

Design

Repeated national interview surveys in 1996 (731 men and 868 women) and 2004 (727 men and 864 women) aged 18 years or more.

Main outcome measure

Prevalence of current smoking.

Results

The age standardised prevalence of smoking in 1996 and 2004 was 61% and 63%, respectively in men and 15% and 16%, respectively in women (both p values > 0.4). In men, the prevalence of smoking seemed to decline in those with university education (from 51% to 40%, p  =  0.085). Among women, smoking appeared to increase in those with university education (from 10% to 17%, p  =  0.071) and low levels of self‐reported material deprivation (from 11% to 18%, p  =  0.053). There was a pronounced increase in prevalence among women living in villages (from 8% to 14%, p  =  0.049); the strong urban/rural gradient seen in 1996 became considerably weaker by 2004.

Conclusions

Overall smoking prevalence in both men and women in Russia remained stable between 1996 and 2004 but, given the sample size, a moderate increase in female smoking cannot be ruled out. In men, smoking increased among the least educated and declined in the most educated. In women the opposite appeared to occur, in addition to an increase in smoking in rural areas. More long term monitoring of smoking patterns in Russia, especially among women, using sufficiently large surveys, is required.     

Trends in the prevalence of smoking in Russia during the transition to a market economy

Background

Changes in smoking, particularly an increase in women, were predicted to follow the aggressive campaigns of multinational tobacco companies in transitional Russia. However, such changes have not yet been demonstrated unequivocally.

Objective

To examine smoking trends by gender, education and area of residence.

Methods

Data from 10 rounds of the Russia Longitudinal Monitoring Survey (1992–2003), consisting of more than 3000 men and 4000 women in each round, were used. The mean reported ages of first smoking in current smokers were compared between 10‐year birth cohorts.

Results

Between 1992 and 2003, smoking prevalence doubled among women from 6.9% (95% CI 6.3% to 7.6%) to 14.8% (13.9% to 15.7%) and increased among men from 57.4% (95% CI 56.0% to 58.8%) to 62.6% (61.1% to 64.1%). In both sexes, the rise was significantly greater in the least educated, markedly so in women (a doubling vs a 1.5‐fold rise in the most educated). Although prevalence of smoking among women was considerably higher in Moscow and St Petersburg than in rural areas, the dramatic threefold increase in prevalence in rural women was significantly greater than in the main cities (36%, p<0.001). The mean age of first smoking was significantly lower in women born after 1960, but in men it was stable between cohorts.

Conclusions

For the first time, it has been shown unequivocally that smoking among women increased markedly during the transition to a market economy in Russia. The already high prevalence of smoking among men has continued to rise. These changes are likely to reflect the activity of the tobacco industry and provide further evidence of the harms of privatisation. Effective tobacco control policies are urgently needed.The collapse of the Soviet Union led to massive changes in the region''s cigarette industry; state‐owned tobacco monopolies were privatised, and the transnational tobacco companies (TTCs) invested heavily.¹ This led to a massive surge in advertising and a change in distribution strategies, which were shown by tobacco industry documents to be targeted particularly at women, young people and those living in cities, and which were accompanied by a weakening in tobacco control legislation as a result of aggressive lobbying by the industry.^2,3,4,5 Cigarette consumption across the region increased almost exponentially.⁶In Russia alone, the TTCs invested approximately US$1.7 billion between 1992 and 2000, gaining a collective market share of over 60% and increasing by fourfold the production capacity in their newly acquired factories.¹ Various numbers of new brands were introduced; Japan Tobacco International, for example, introduced eight new brands in 1999 alone.⁷ Advertising, which had been non‐existent in Soviet times, escalated massively to promote such brands as an indispensable part of the “western lifestyle”.^8,9 By the mid 1990s, it was estimated that up to 50% of all billboards in Moscow and 75% of plastic bags in Russia carried tobacco advertising;¹⁰ tobacco soon became the product most heavily advertised outdoors, with three major transnationals ranked as the first, second and third heaviest advertisers.¹¹ After the initial targeting of urban areas, industry documents state that the focus was on expanding marketing efforts to other regions of Russia.^12,13 Since the transition, tobacco control policies in Russia have largely been dictated by the tobacco industry. In 1995, for example, a new law on advertising was implemented, based on the industry''s voluntary code of conduct,^14,15 and changes to the federal bill on Limitation of Tobacco Consumption, signed in 2001, were described by the St Petersburg Times as “a textbook demonstration of the lobbyist''s art”.¹⁶Although the tobacco epidemic in men in Russia, as in the rest of the former Soviet Union (FSU), is well established,¹⁷ and smoking rates among men have been high for decades, rates have failed to decline, as models of the tobacco epidemic would predict.^18,19 In women, the tobacco epidemic is at an earlier stage. Survey data show far higher rates of smoking among young than among older women, particularly in countries targeted by the TTCs, which, combined with comparisons with historical data, suggest an increase in smoking rates among women. However, such an increase is yet to be established unequivocally, as previous efforts to examine these and other trends in the tobacco epidemic have been limited by the lack of truly comparable data and the small sample size of repeated surveys.^19,20In addition to the marked changes in the region''s tobacco industry, the need to address these research gaps is underlined by the fact that the accumulated burden of tobacco‐related disease among men <75 years of age in the FSU is the highest in the world.²¹ More than half of Russian men smoke,^19,20 and estimates indicate that smoking presently accounts for nearly half of male deaths and just <4% of female deaths.²² This work will also further efforts to understand the impacts of privatisation of the tobacco industry, which continues to be promoted by the International Monetary Fund.^4,18In this paper, we used data from the Russia Longitudinal Monitoring Survey (RLMS), a large panel study comprising data collected in 10 rounds between 1992 and 2003, to study trends in smoking and to explore in detail the impact of the entry of TTCs on smoking habits. We hypothesised, based largely on the actions of the privatised tobacco companies now active in Russia, that smoking among women would increase, the age of smoking uptake would fall, and that rates of smoking among women in rural areas would tend to increase towards those already observed in urban areas. In men, we predicted little change in smoking rates, but an increase in educational inequalities in smoking.     

Ethylene and 1‐hexene sorption in LLDPE under typical gas‐phase reactor conditions: Experiments

The sorption of ethylene and 1‐hexene and their mixture in three poly(ethylene‐co‐1‐hexene) samples is measured gravimetrically at temperatures 70, 90, and 150°C and pressures 0–30 bar. Gravimetric sorption measurements are supplemented with microscopic observations of swelling of polyethylene particles caused by sorption and the extent of swelling is found to be significant. Experimental data are compared with predictions of PC‐SAFT (perturbed chain—‐statistical associating fluid theory) equation of state. Comparison of sorption data in semicrystalline polymer (measured at 70 and 90°C) and amorphous polymer (at 150°C) demonstrates the constraining effect of semicrystalline structure. Solubilities of penetrants in investigated samples are not observed to depend on the content of 1‐hexene in copolymers. The solubility of the mixture of ethylene and 1‐hexene is smaller than the sum of solubilities of individual components at 70 and 90°C. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 1124–1136, 2006