Maintenance Scheduling Optimization in a Multiple Production Line Considering Human Error

An analytical multiobjective maintenance planning model that maximizes reliability while minimizing cost and human error is proposed. In order to incorporate human error, the model minimizes the maximum human error over the planning horizon. Human Error Assessment and Reduction Technique (HEART) is used to quantify the human error. Maintenance activities include adjustment and replacement activities, in which each of them consumes a certain amount of human resource, spare parts, and budget and brings about a specified level of reliability and human error. Economic dependence is also considered, in which grouping maintenance activities reduces total cost. However, this may increase human error probability due to operator fatigue or time pressure. The main purpose is to investigate the relationship between human factors and maintenance activities to find the preferred maintenance plan. A multiple production line is considered as a case study. A sensitivity analysis is performed, and the effects of grouping and human factors on the preferred maintenance plan are discussed. It is shown how human proficiency may affect reliability and cost.     

A new method for detecting various variants of GoF design patterns using conceptual signatures

Software design patterns are well-known solutions for solving commonly occurring problems in software design. Detecting design patterns used in the code can help to understand the structure and behavior of the software, evaluate the quality of the software, and trace important design decisions. To develop and maintain a software system, we need sufficient knowledge of design decisions and software implementation processes. However, the acquisition of knowledge related to design patterns used in complex software systems is a challenging, time-consuming, and costly task. Therefore, using a suitable method to detect the design patterns used in the code reduces software development and maintenance costs. In this paper, we proposed a new method based on conceptual signatures to improve the accuracy of design pattern detection. So we used the conceptual signatures based on the purpose of patterns to detect the patterns’ instances that conform to the standard structure of patterns, and cover more instances of patterns’ variants and implementation versions of the patterns and improve the accuracy of pattern detection. The proposed method is a specific process in two main phases. In the first phase, the conceptual signature and detection formula for each pattern is determined manually. Then in the second phase, each pattern in the code is detected in a semi-automatic process using the conceptual signature and pattern detection formula. To implement the proposed method, we focused on GoF design patterns and their variants. We evaluated the accuracy of our proposed method on five open-source projects, namely, Junit v3.7, JHotDraw v5.1, QuickUML 2001, JRefactory v2.6.24, and MapperXML v1.9.7. Also, we performed our experiments on a set of source codes containing the instances of GoF design patterns’ variants for a comprehensive and fair evaluation. The evaluation results indicate that the proposed method has improved the accuracy of design pattern detection in the code.

     

Preparation and Characterization of Magnetite–Chitosan Nanoparticles and Evaluation of Their Cytotoxicity Effects on MCF7 and Fibroblast Cells

Nowadays, magnetic nanoparticles play a key role in drug treatment. However, if they are uncoated, they might aggregate and cause embolism in drug delivery. To avoid this, they are generally coated with polymers. In this investigation, magnetic nanoparticles (MNPs) were coated with chitosan through in situ co-precipitation process and their properties in addition to their cytotoxicity in MCF7 and fibroblast cells were analyzed. The results showed MNPs–chitosan nanoparticles would contain an average mean diameter of 32 nm and a saturation magnetization (M _S) value of 38.87 emu/g. To characterize the synthesized nanoparticles in terms of structural, morphological and magnetic properties, Fourier transform infrared (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermal gravimetric analysis (TGA) and vibrating sample magnetometry (VSM) studies were used. Toxicity test was also done to investigate whether their presence would cause any toxicity in the body; in addition, antibacterial assay was done to analyze if nanoparticles could be used as an antimicrobial agent.     

Combination of multiple diverse classifiers using belief functions for handling data with imperfect labels

This paper addresses the supervised learning in which the class memberships of training data are subject to ambiguity. This problem is tackled in the ensemble learning and the Dempster-Shafer theory of evidence frameworks. The initial labels of the training data are ignored and by utilizing the main classes’ prototypes, each training pattern is reassigned to one class or a subset of the main classes based on the level of ambiguity concerning its class label. Multilayer perceptron neural network is employed to learn the characteristics of the data with new labels and for a given test pattern its outputs are considered as basic belief assignment. Experiments with artificial and real data demonstrate that taking into account the ambiguity in labels of the learning data can provide better classification results than single and ensemble classifiers that solve the classification problem using data with initial imperfect labels.