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排序方式: 共有167条查询结果,搜索用时 31 毫秒
1.
JM Piepmeier DL Keefe MA Weinstein D Yoshida J Zielinski TT Lin Z Chen F Naftolin 《Canadian Metallurgical Quarterly》1993,32(3):422-30; discussion 430-1
Estramustine is an estradiol-based agent that has been shown to accumulate in human glioma cells, resulting in a concentration-dependent alteration in cell size and shape within minutes and an inhibition of proliferation over 3 to 6 days. We evaluated human glioblastoma cultures with [3H]thymidine incorporation assays to determine estramustine's early effects on deoxyribonucleic acid synthesis in these tumors. Because estramustine shares a common structural motif with other antimicrotubule drugs, we synthesized four A-ring conjugates of estrone that contained a carbamate moiety but lacked nitrogen mustard. These analogs were examined by [3H]thymidine incorporation and compared with vinblastine. Greater than 70% inhibition of [3H]thymidine incorporation occurred within 1 hour of treatment with estramustine at 10(-5) mol/L, which increased to 80% inhibition at 4 hours. Ethyl carbamate JE208 was nearly as effective as estramustine in inhibiting deoxyribonucleic acid synthesis, and both were more effective than vinblastine. The inhibitory effects of estramustine and estrone analogs were reversible; vinblastine was not reversible. Although estramustine and JE208 induced similar antiproliferative and morphological changes in glioblastoma cells that persisted for at least 4 days, there was a modest recovery of morphology and thymidine incorporation with JE208 after prolonged treatment. The common findings with estramustine and JE208 suggest that these agents may have a similar mechanism of action and form the basis for the investigation of new agents that may rapidly and reversibly inhibit glioblastoma. 相似文献
2.
A study was undertaken to determine fertility in a group of females who as children had been operated on for appendicitis. The 134 women operated on for appendicitis were reviewed. Their ages ranged from 2-18 years at the time of appendectomy. Our data show that perforated appendicitis before puberty has little if any role in the etiology of tubal infertility. 相似文献
3.
W. W. Gerberich H. Huang W. Zielinski P. G. Marsh 《Metallurgical and Materials Transactions A》1993,24(3):535-543
An interconnected set of observations assesses current equilibrium models of the ductile-brittle-transition temperature (DBTT).
This involvesin situ transmission electron microscopy (TEM) studies of crack-tip dislocations in single and polycrystals and bulk fracture toughness
tests at various temperatures. Beyond KI values of 8 MPa · m1/2 in both iron-base single and polycrystals, large numbers of redundant dislocations are created, as postulated recently by
Weertman. [38] Still, the necessary shielding dislocations, as required by equilibrium, can be detected at values as high
as 20 and 40 MPa · m1/2 byex situ TEM and electron channeling, respectively. In addition, the close approach of dislocations to the crack tip in some of the
studies, as opposed to others, suggests that large dislocation free zones (DFZ) are a thin-film artifact. However, a failure
criterion based partly on the Rice-Thomson model’21 is both consistent with the absence of a large DFZ and observed fracture
toughness variations with test temperature. It is emphasized that this toughness transition is entirely in the semibrittle
regime where cleavage is the failure mode. Nevertheless,K
lc values increase from 3 to 60 MPa·m1/2 with an increase in test temperature.
This article is based on a presentation made in the symposium “Quasi-Brittle Fracture” presented during the TMS fall meeting,
Cincinnati, OH, October 21–24, 1991, under the auspices of the TMS Mechanical Metallurgy Committee and the ASM/MSD Flow and
Fracture Committee. 相似文献
4.
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6.
A key aspect of resource management is efficient and effective deployment of available resources whenever needed. The issue typically covers two areas: monitoring of resources used by software systems and managing the consumption of resources. A key aspect of each monitoring system is its reconfigurability – the ability of a system to limit the number of resources monitored at a given time to those that are really necessary at any particular moment. The authors of this article propose a fully dynamic and reconfigurable monitoring system based on the concept of Adaptable Aspect-Oriented Programming (AAOP) in which a set of AOP aspects is used to run an application in a manner specified by the adaptability strategy. The model can be used to implement systems that are able to monitor an application and its execution environment and perform actions such as changing the current set of resource management constraints applied to an application if the application/environment conditions change. Any aspect that implements a predefined interface may be used by the AAOP-based monitoring system as a source of information. The system utilizes the concept of dynamic AOP, meaning that the aspects (which are sources of information) may be dynamically enabled/disabled. 相似文献
7.
A Fast Search Algorithm for a Large Fuzzy Database 总被引:1,自引:0,他引:1
Feng Hao Daugman J. Zielinski P. 《Information Forensics and Security, IEEE Transactions on》2008,3(2):203-212
In this paper, we propose a fast search algorithm for a large fuzzy database that stores iris codes or data with a similar binary structure. The fuzzy nature of iris codes and their high dimensionality render many modern search algorithms, mainly relying on sorting and hashing, inadequate. The algorithm that is used in all current public deployments of iris recognition is based on a brute force exhaustive search through a database of iris codes, looking for a match that is close enough. Our new technique, Beacon Guided Search (BGS), tackles this problem by dispersing a multitude of ldquobeaconsrdquo in the search space. Despite random bit errors, iris codes from the same eye are more likely to collide with the same beacons than those from different eyes. By counting the number of collisions, BGS shrinks the search range dramatically with a negligible loss of precision. We evaluate this technique using 632,500 iris codes enrolled in the United Arab Emirates (UAE) border control system, showing a substantial improvement in search speed with a negligible loss of accuracy. In addition, we demonstrate that the empirical results match theoretical predictions. 相似文献
8.
This paper describes the Si-doping of GaAs that was grown using the AsCl3:H2:GaAs, Ga Chemical vapor deposition process. The doping sources were AsCl3:SiCl4 liquid solutions which proved to be highly reproducible for Si doping within the range, 1×1O16 to 2×1019 cm?3. Incorporation of Si into the GaAs apparently occurs under near equilibrium conditions. This point is considered in detail and the consequences experimentally utilized to grow n, n+ bilayers using a single AsCl3:SiCl4 doping solution. Si impurity profiles based upon differential capacitance and SIMS data are presented. These can be very abrupt for n, n+ structures with order of magnitude changes occurring within 500 Å. For the 1×1016 to 8×l018 cm?3 doped samples the mobilities at 78 and 298°K are comparable to the higher values reported for GaAs thin films grown by CVD. Power FET devices made from this material have demonstrated an output density of 0.86 watts/mm at 10 GHz. 相似文献
9.
The 2009 Passive and Low Energy Architecture Conference (PLEA), held in Québec City, Canada, was themed ‘Architecture, Energy and the Occupant's Perspective’, with the ambition of positioning building inhabitants as key ‘active’ determinants of energy performance in ‘passive’ design through adaptive opportunities. Conference delegates committed to a Manifesto that embodied both the key longstanding priorities of PLEA and explicitly conveyed the priorities of the conference hosts. The Manifesto is examined in terms of how it captures and represents a shift in thinking that has occurred over the past few years, away from technological and technocratic solutions to comfort provisioning and towards reframing building energy consumption as a social and ethical challenge in which comfort plays a key role. La Conférence 2009 sur l'Architecture Passive et Basse Energie (PLEA), qui s'est tenue à Québec, au Canada, avait pour thème « Architecture, Energie et la Perspective de l'Occupant », avec pour ambition de positionner les habitants d'immeubles comme principaux déterminants « actifs » de la performance énergétique dans un design « passif » par des opportunités d'adaptation. Les délégués de la conférence se sont engagés en faveur d'un Manifeste qui, tout à la fois, incarne les principales priorités qui sont depuis longtemps celles des Conférences PLEA et traduit explicitement les priorités des hôtes de la conférence. Cet article examine le Manifeste quant à la manière dont il appréhende et reflète le changement intervenu au cours de ces dernières années dans la manière de voir les choses, consistant à se détourner d'un confort fourni par des solutions technologiques et technocratiques et à aller dans le sens d'un recadrage de la consommation énergétique des immeubles considérée comme un défi social et éthique dans lequel le confort joue un rôle clé. Mots clés: comportement adaptatif, agence, confort, fourniture du confort, qualité environnementale intérieure, habitants, manifeste, Conférence sur l'Architecture Passive et Basse Energie (PLEA) 相似文献
10.
Several model polyenes with modified indanone groups were studied by means of density functional theory (DFT) B3LYP/6-31G*, ab initio HF/3-21G* and semiempirical AM1 methods. We investigated the effect of several substituents upon the relationship between the structure, spatial distribution of the highest occupied and the lowest unoccupied pi-MOs, a concept of the global softness and the global hardness as well as both linear and nonlinear polarizabilities for the set of pi-electron chromophores represented by the short-chain model polyene (butadiene) carrying out p-methoxyphenyl group on the one end and several modified indanone groups on the opposite end of the molecule. As probing endocyclic groups used to modify the structure of indanone the following substituents: > CH2; > C=O; > SO2, > C=CH(NO2) and > C=C(CN)2 were selected. The cubic relationship between the polarizability and the global softness was found. The highest polarizabilities (alpha, beta, gamma) are predicted for the derivatives with > C=C(CN)2 group. It was found that the value of beta depends mainly on the difference between dipole moments in the excited and ground states of the molecules. In the case of > SO2 group the results of AMI calculations significantly deviate from relationships found for other derivatives. Experimental IR and Raman spectra of newly synthesized indandione derivative of cinnamaldehyde were compared with computed ones. 相似文献