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Teresa Gonzlez Muoz Ana Teresa Amaral Pilar Puerto-Camacho Hctor Peinado Enrique de lava 《International journal of molecular sciences》2021,22(6)
A spotlight has been shone on endoglin in recent years due to that fact of its potential to serve as both a reliable disease biomarker and a therapeutic target. Indeed, endoglin has now been assigned many roles in both physiological and pathological processes. From a molecular point of view, endoglin mainly acts as a co-receptor in the canonical TGFβ pathway, but also it may be shed and released from the membrane, giving rise to the soluble form, which also plays important roles in cell signaling. In cancer, in particular, endoglin may contribute to either an oncogenic or a non-oncogenic phenotype depending on the cell context. The fact that endoglin is expressed by neoplastic and non-neoplastic cells within the tumor microenvironment suggests new possibilities for targeted therapies. Here, we aimed to review and discuss the many roles played by endoglin in different tumor types, as well as the strong evidence provided by pre-clinical and clinical studies that supports the therapeutic targeting of endoglin as a novel clinical strategy. 相似文献
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Pilar Puerto-Camacho Juan Díaz-Martín Joaquín Olmedo-Pelayo Alfonso Bolado-Carrancio Carmen Salguero-Aranda Carmen Jordn-Prez Marina Esteban-Medina Inmaculada lamo-lvarez Daniel Delgado-Bellido Laura Lobo-Selma Joaquín Dopazo Ana Sastre Javier Alonso Thomas G. P. Grünewald Carmelo Bernabeu Adam Byron Valerie G. Brunton Ana Teresa Amaral Enrique De lava 《International journal of molecular sciences》2022,23(15)
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