A numerical study of wave propagation and run-up in water channels

It is important to understand how water waves propagate through water channels in order to reduce inundation damages induced by surges and/or tsunami run-up. For this purpose, a two-dimensional numerical model is developed based on Nonlinear Shallow Water Equations. In order to appropriately describe the strongly nonlinear hydrodynamics, a high-order TVD scheme is implemented. Model capabilities are confirmed through comparison with existing analytical studies including the dam-break problems, run-up and back-wash on a sloping bathymetry. The model is then applied to the study on the inundation of bore propagating in a channel of parabolic cross-section from a side breach.

     

Effects of muscle relaxants on catecholamine release from the bovine adrenal medulla

Studies on the structure and substrate specificity of purified rat kidney nuclear (RKN) lysozyme are reported. The carboxyl and amino terminal residues of RKN-lysozyme were found to be leucine and alanine respectively. The amino acid composition indicated similarities and differences as compared with that of hen egg white (HEW) lysozyme. There were alterations in the nine amino acid residues, Lys, His, Arg, Asp, Glu, Pro, 1/2 Cys, Tyr and Trp. The other nine residues were present in identical proportions to those of HEW-lysozyme. The decrease in the arginine and aspartic acid residues was found to be compensated by the increase in the number of lysine, histidine and glutamic acid residues. The overall ratio of the acidic to basic amino acids has thus been conserved in the mammalian enzyme. In addition, RKN-lysozyme contained decreased numbers of Trp, Tyr and 1/2 Cys, and increased numbers of proline residues as found in HEW-lysozyme. RKN-lysozyme did not cross react with heterologous antibodies produced against HEW-lysozyme, and vice versa. RKN-lysozyme showed distinct specificity towards the lysis of M. luteus. Against this substrate, it was three times more efficient than HEW-lysozyme. It also cleaved E. coli B, but its efficiency was half as much as with M. luteus. However, it cleaved P. septica and B. subtilis at a rate similar to HEW-lysozyme under identical conditions.