Emotional stress is believed to be associated with increased tumor progression. Stress-induced epigenetic modifications can contribute to the severity of disease and poor prognosis in cancer patients. The current study aimed to investigate the expression profiles along with the prognostic significance of psychological stress-related genes in metastatic breast cancer patients, to rationalize the molecular link between emotional stress and cancer progression. We profiled the expression of selected stress-associated genes (5-HTT, NR3C1, OXTR, and FKBP5) in breast cancer including the stress evaluation of all participants using the Questionnaire on Distress in Cancer Patients–short form (QSC-R10). A survival database, the Kaplan–Meier Plotter, was used to explore the prognostic significance of these genes in breast cancer. Our results showed relatively low expressions of 5-HTT (p = 0.02) and OXTR (p = 0.0387) in metastatic breast cancer patients as compared to the non-metastatic group of patients. The expression of NR3C1 was low in tumor grade III as compared to grade II (p = 0.04). Additionally, the expression of NR3C1 was significantly higher in patients with positive estrogen receptor status. However, no significant difference was found regarding FKBP5 expression in breast cancer. The results suggest a potential implication of these genes in breast cancer pathology and prognosis. 相似文献
Water Resources Management - The use of wavelet-coupled data-driven models is increasing in the field of hydrological modelling. However, wavelet-coupled artificial neural network (ANN) models... 相似文献
In this work, an intelligent computing algorithm is developed for finding the approximate solution of heart model based on nonlinear Van der Pol (VdP)-type second-order ordinary differential equations (ODEs) using feed-forward artificial neural networks (FF-ANNs) optimized with genetic algorithms (GAs) hybrid through interior-point algorithm (IPA). The mathematical modeling of the system is constructed using FF-ANN models by defining an unsupervised error and unknown weights; the networks are tuned globally with GAs, and local refinement of the results is made with IPA. Design scheme is applied to study the VdP heart dynamics model by varying the pulse shape modification factor, damping coefficients and external forcing factor while keeping the fixed value of the ventricular contraction period. The results of the proposed algorithm are compared with reference numerical solutions of Adams method to establish its correctness. Multiple independent runs are performed for the scheme, and results of statistical analyses in terms of mean absolute deviation, root-mean-square error and Nash–Sutcliffe efficiency illustrate its applicability, effectiveness and reliability.
AbstractFrequency, amplitude, and phase information of the grid voltage are the main constraints for constructing a robust controller algorithm for grid connected applications under unbalanced and distorted voltage conditions. This paper narrates a simple, robust, straight forward method to estimate the instantaneous positive and negative sequence voltage components under unbalanced and distorted voltage circumstances. A second order generalized integrator (SOGI) is encapsulated to filter out the distorted voltage as well as to generate orthogonal voltage components for the three phases of AC grid. Furthermore, these filtered and orthogonal components are accounted for the calculation of instantaneous symmetrical components. Developed technique is more frequency adaptive compared to conventional phase locked loop (PLL) techniques. A set of test outcome results are provided in this paper based on MATLAB/Simulink simulations with real grid data captured from an industrial plant. Moreover, SOGI based estimator is digitally implemented by using dSPACE ds1103 digital controller to validate the numerical simulation results in accordance with the developed theoretical prediction. 相似文献
The catalysts for oxygen evolution reaction (OER) are required to generate clean energy. Herein, one-step solvothermal synthesis and modification of amino functionalized Zr-based metal organic framework, UiO-66-NH2, is reported. The catalytic efficiency of UiO-66-NH2 towards OER is improved by incorporating the cerium-based nanocomposite such as Ce2O3, TiO2/Ce2O3 and CoO/Ce2O3. The synthesized samples are characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, diffraction, and ultraviolet–visible spectroscopy. The synthesized materials are coated on nickel foam for investigating the catalytic activity towards OER by cyclic voltammetry and linear sweep voltammetry. Amongst, CoO/Ce2O3@UiO-66-NH2/NF exhibits excellent OER-catalytic activity and delivers 10 mA cm?2 current density at just 228 mV overpotential which is superior to many previously reported OER catalysts and its comparative products. To understand kinetics, Tafel slope is derived from LSV curve and is just 92 mV dec?1.
This research investigates the growing phenomenon of university–industry (U–I) collaboration in high-tech strategic projects in China. After significant changes in the trading policies of 1978, China has gained heightened attention in technology and innovation. To achieve the stated strategic national goals, Research and Development (R&D) collaboration is essential. Organizations preferred to collaborate in order to share the burden of R&D costs and efforts. The academic outputs (research publications) of Chinese academic institutions and technology patenting ratio are increasing daily in China. These increasing numbers signal the importance of R&D. High-tech industries are inclined to share projects with universities. Foreign enterprises, state supported enterprises and local industry have played key roles to strengthening university–industry relationships. 相似文献
Electromagnetic scattering from a topological insulator (TI) cylinder buried beneath a rough surface is considered. To account for the interactions of the scattered field and the rough surface, spectral plane wave representation of fields is used along with small perturbation method. Both time-reversal symmetry TI cylinder and time-reversal symmetry broken TI cylinder are considered to evaluate the scattered-transmitted field above the rough surface for different values of the periods of the rough surface and the size of the object. It is observed that co- and cross-polarized field components show a maximum before the time-reversal symmetry is broken. The co-polarized component remains almost constant while the cross-polarized component decreases for time-reversal symmetry broken case. 相似文献