In Silico Analysis and Experimental Validation of Active Compounds from Cichorium intybus L. Ameliorating Liver Injury

This study aimed at investigating the possible mechanisms of hepatic protective activity of Cichorium intybus L. (chicory) in acute liver injury. Pathological observation, reactive oxygen species (ROS) detection and measurements of biochemical indexes on mouse models proved hepatic protective effect of Cichorium intybus L. Identification of active compounds in Cichorium intybus L. was executed through several methods including ultra performance liquid chromatography/time of flight mass spectrometry (UPLC-TOF-MS). Similarity ensemble approach (SEA) docking, molecular modeling, molecular docking, and molecular dynamics (MD) simulation were applied in this study to explore possible mechanisms of the hepato-protective potential of Cichorium intybus L. We then analyzed the chemical composition of Cichorium intybus L., and found their key targets. Furthermore, in vitro cytological examination and western blot were used for validating the efficacy of the selected compounds. In silico analysis and western blot together demonstrated that selected compound 10 in Cichorium intybus L. targeted Akt-1 in hepatocytes. Besides, compound 13 targeted both caspase-1 and Akt-1. These small compounds may ameliorate liver injury by acting on their targets, which are related to apoptosis or autophagy. The conclusions above may shed light on the complex molecular mechanisms of Cichorium intybus L. acting on hepatocytes and ameliorating liver injury.     

A Spatial Cognitive Model that Integrates the Effects of Endogenous and Exogenous Information on the Hippocampus and Striatum

Machine Intelligence Research - Reproducing the spatial cognition of animals using computational models that make agents navigate autonomously has attracted much attention. Many biologically...     

食品包装用复合膜材质分析方法研究

目的 研究食品包装用复合膜材质的分析方法。方法 样品截面经包埋抛光后, 采用扫描电镜-能谱仪(scanning electron microscope-energy dispersive spectrometer, SEM-EDS)对样品层数及各层元素信息进行表征。样品经甲酸浸泡分层后, 采用傅里叶变换红外光谱仪(fourier transforminfrared spectroscopy, FT-IR)、差式扫描量热仪(differential scanning calorimetry, DSC)、SEM-EDS对分层后各层薄膜的红外特征吸收峰、熔点、元素信息进行表征。结果 确认该复合膜具有4层结构, 从外表面到内表面材质依次为PET层(厚度约13 μm)、PA层(厚度约16 μm)、铝层(厚度约10 μm)、PP/PE共混层(厚度约67 μm)。结论 通过溶剂剥离分层, SEM-EDS、FT-IR、DSC连用表征分析, 可以确认食品包装用复合膜的多层膜整体结构及每层薄膜材质。     

网络攻击效果在线评估模型与算法研究

为了顺利实现预定的攻击目标,在线评估攻击效果并制定适当的攻击策略都是非常重要的。本文讨论了网络攻击效果与目标网络系统安全性之间的关系,提了一种基于网络安全性改变量的攻击效果定义方法;重点研究了网络攻击效果在线评估的评估模型和评估算法;提出了网络攻击效果的评价准则和评估指标体系;设计并给出了网络攻击效果在线评估系统的框架模型;详细讨论了网络攻击效果在线评估的评估算法、状态图生成算法、攻击效果预测算法和攻击方案决策算法。     

文一污水站减少污泥产生量的污水处理技术

为了减少文一污水站按现行工艺在高pH(8.0-8.5)下处理油田污水过程中产生的污泥量，开发了一种新的污水处理工艺，在室内实验条件下，用一种pH调节剂将污水pH控制在7．0－7．5，加入除铁剂，除铁增效剂各100mg/L，得到了最好的净水效果（滤膜系数MF＞30），车原污水相比，净化水污泥产生量由10．8g/L降至－1g/L，50℃，15d静态腐蚀速率为0．0089－0．0110mm/a，平均0．0097mm/a，SRB菌数为0，TGB菌数0－10^1个／mL，与地层水完全配伍；矿化度和主要成垢离子浓度有所降低。在文一污进行了为期47d的现场试验，结果表明：（1）在pH6.8-7.2，除铁剂和增剂剂加量分别为150，130mg/L时，净水效果最好，外输入MF＞28，SS 5mg/L，含油2mg/L，（2）pH增大时污泥产生量增大，处理后水水质变差；（3）pH6.8-7.2除铁剂130mg/L，增效剂100mg/L为最佳净水条件，外输水MF＞20；（4）净化水腐蚀性符合水质指标，主要腐蚀因素是二次沉降罐曝氧，加入Na2SO3可降低溶解氧含量，但引起水质下降；（5）试验期间污泥量减少1／2－1／3。（6）处理后水水质波动主要是水量波动引起的。     

一种用于AFS的半实物仿真平台

为了给自适应前照灯系统（Adaptive Front-Lighting System,AFS）提供一个控制算法验证平台,开发了一套基于汽车驾驶模拟器的AFS半实物硬件仿真平台。在该仿真平台中,PC机采集驾驶模拟器的档位、油门、离合、刹车、方向盘等驾驶信息,由车辆动力学模型模拟实际车辆行为,采用AFS控制模型计算车灯转角控制量,并发送至电机驱动模块进而控制车灯转动,同时将车灯转角信息反馈至PC机。实验表明,该系统能实时记录和显示AFS工作过程中的多种参数,便于进行实验观察和数据分析,从而为AFS系统的控制算法提供一个检验和修正的平台。     

(en)Mn2(V2O7): A 3D manganese vanadate built by Mn–O layers and two types of pillars of V2O7 and en bridges

An unexpected 3D manganese vanadate (en)Mn₂(V₂O₇) (1) (en = ethylenediamine) has been hydrothermally obtained by H₂E₂Ge₂O₃ (E = ? CH₂CH₂COO^?) ligands and well-prepared mixture of V–Mn-amine and characterized by IR spectroscopy, elemental analysis, thermal stability and powder X-ray diffraction. Single-crystal X-ray diffraction analysis reveals that the structure is a novel pillared-layer, in which MnO₅N octahedra are corner-linked to form an infinite sheet with 4-membered rings (MRs) and further condensed to the 3D framework. The most prominent feature of 1 is the connection between the sheets via double bridges, namely, inorganic V₂O₇ dimeric units and organic en molecules. It is noteworthy that inorganic and organic double bridges between sheets have not been seen in manganese vanadates.     

Enhanced room-temperature magnetoelectric coupling effects in c-axis oriented polycrystalline BaSrCo2-xMgxFe11AlO22

The influence of applied magnetic field during annealing process as well as of Mg doping on the room-temperature magnetoelectric coupling effects in BaSrCo_2-xMg_xFe₁₁AlO₂₂ are experimentally studied through the magnetization, magnetodielectric, and magnetoelectric current measurements. Hexaferrite samples of Co₂Y were found to be highly oriented by an applied magnetic field (H_o) during the annealing process, leading to an enhancement of the room-temperature magnetoelectric coupling effects. Although the substitution of nonmagnetic Mg ions in Co sites tends to reduce the ferromagnetism at macroscopic scale, a proper amount of Mg doping content facilitates the superexchange interaction between the adjacent magnetic blocks; meanwhile modulates the magnetic anisotropy in the samples. An appropriate adjustment of the competition between the anisotropy and the superexchange could enhance the magnetoelectric coupling at room temperature, which can be confirmed by the magnetic-field-induced dielectric constant and current density study.     

An unprecedented dumbbell-shaped pentadeca-nuclear W-Er heterometal cluster stabilizing nanoscale hexameric arsenotungstate aggregate and electrochemical sensing properties of its conductive hybrid film-modified electrode

Cluster-based functional materials have made remarkable progress owing to their wonderful structures and distinctive physicochemical performances,one of on-goin...     

2015—2019年欧盟食品和饲料快速预警系统对华食品农兽药残留通报的数据分析

以2015年至2019年欧盟食品和饲料快速预警系统(rapid alert system for foodand feed, RASFF) 通报数据为基础, 对华通报的食品中农药兽药残留数据进行分析, 反映我国出口食品的质量安全状况。通过不同通报类型、通报国家、通报项目、采取措施等多维度数据对比进行了对华通报食品农兽药安全状况分析。结果显示农药残留依旧是制约我国农产品出口贸易的主要因素,不合格农药残留食品涉及的食品品种呈现出多元化的趋势,高剧毒农药的使用屡见不鲜。应通过制定完善的标准、治理种植养殖环境、强化监督管理等多措并举,降低出口贸易风险。