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排序方式: 共有350条查询结果,搜索用时 15 毫秒
1.
Rossato Janine I.; Bonini Juliana S.; Coitinho Adriana S.; Vianna Monica R. M.; Medina Jorge H.; Cammarota Martín; Izquierdo Iván 《Canadian Metallurgical Quarterly》2004,118(3):563
The gamma aminobutyric acid-A (GABAA) agonist, muscimol, the glutamate N-methyl-D-aspartate (NMDA) receptor antagonist, D-2-amino-5-phosphonopentanoic acid (AP5), and the inhibitor of the extracellularly regulated kinases (ERKs), UO 126, cause retrograde amnesia when administered to the hippocampus. In the present study, the authors found that they all cause retrograde amnesia for 1-trial inhibitory avoidance, not only when infused into the dorsal CA1 region of the hippocampus, but also when infused into the basolateral amygdala or the entorhinal, parietal, and posterior cingulate cortices. The posttraining time course of the effect of each drug was, however, quite different across brain structures. Thus, in all of them, NMDA receptors and the ERK pathway are indispensable for memory consolidation, and GABAA receptor activation inhibits memory consolidation: but in each case, their influence is interwoven differently. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
2.
In the development of a novel freeze-drying technique in a fluidized bed at atmospheric pressure, a parallel study was undertaken using a conventional vacuum equipment. Two kinetically distinct phases were observed during freeze drying of representative Pood samples:
(1) a period during which the rate of drying was constant and (2) a second period during which the drying rate sufferedcontinual reduction. This paper focused attention on the primary drying period which corresponded with the kinetics of sublimation of pure 相似文献
(1) a period during which the rate of drying was constant and (2) a second period during which the drying rate sufferedcontinual reduction. This paper focused attention on the primary drying period which corresponded with the kinetics of sublimation of pure 相似文献
3.
This study examined the role of marital conflict structure--who desires and requests change versus who responds to the change request--in spouses' cardiovascular responses to marital interactions. Forty-one couples discussed 2 marital topics: one in which the wife desired change in the husband, and one in which the husband desired change in the wife. Cardiovascular responses were assessed at 2-min intervals. Results indicated that marital conflict structure moderates cardiovascular reactivity during negative marital interactions: Husbands and wives whose interactions were characterized by high levels of negative behavior showed the most pronounced diastolic blood pressure reactivity, but only when they were in the role of desiring change in their spouses. Implications for gender differences in marital conflict physiology are considered. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
4.
Izard Carroll E.; Fantauzzo Christina A.; Castle Janine M.; Haynes O. Maurice; Rayias Maria F.; Putnam Priscilla H. 《Canadian Metallurgical Quarterly》1995,31(6):997
Four studies examined aspects of the differential emotions theory (DET) hypothesis of expressive behavior development. In Study 1, facial-expressive movements of 108 2.5–9-mo-old infants were video recorded in positive and negative mother–infant interactions (conditions). As expected, Max-specified full-face and partial expressions of interest, joy, sadness, and anger were morphologically stable between the 2 ages. Studies 1 and 2 confirmed predicted differential responding to mother sadness and anger expressions and to composite positive and negative conditions. Discrete negative expressions exceeded negative blends, and the amount of both expression types remained stable across ages. Studies 3 and 4 provided varying degrees of support for the social validity of Max-specified infant negative affect expressions. Conclusions include revisions and clarifications of DET. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
5.
In 6 rats with electrodes in the medial forebrain bundle, the upper portion of the function relating the experienced magnitude of the reward to pulse frequency was determined at currents ranging from 100 to 1,000 μA. The pulse frequency required to produce an asymptotic level of reward was inversely proportional to current except at the lowest currents and highest pulse frequencies. At a given current, the subjective reward magnitude functions decelerated to an asymptote over an interval in which the pulse frequency doubled or tripled. The asymptotic level of reward was approximately constant for currents between 200 and 1,000 μA but declined substantially at currents at or below 100 μA and pulse frequencies at or above 250 to 400 pulses per second. Results are consistent with the hypothesis that the magnitude of the experienced reward depends only on the number of action potentials generated by the train of pulses in the bundle of reward-relevant axons. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
6.
Sofia Cotton Dylan Ferreira Janine Soares Andreia Peixoto Marta Relvas-Santos Rita Azevedo Paulina Piairo Lorena Diguez Carlos Palmeira Luís Lima Andr M. N. Silva Lúcio Lara Santos Jos Alexandre Ferreira 《International journal of molecular sciences》2021,22(4)
Esophageal cancer (EC) is a life-threatening disease, demanding the discovery of new biomarkers and molecular targets for precision oncology. Aberrantly glycosylated proteins hold tremendous potential towards this objective. In the current study, a series of esophageal squamous cell carcinomas (ESCC) and EC-derived circulating tumor cells (CTCs) were screened by immunoassays for the sialyl-Tn (STn) antigen, a glycan rarely expressed in healthy tissues and widely observed in aggressive gastrointestinal cancers. An ESCC cell model was glycoengineered to express STn and characterized in relation to cell proliferation and invasion in vitro. STn was found to be widely present in ESCC (70% of tumors) and in CTCs in 20% of patients, being associated with general recurrence and reduced survival. Furthermore, STn expression in ESCC cells increased invasion in vitro, while reducing cancer cells proliferation. In parallel, an ESCC mass spectrometry-based proteomics dataset, obtained from the PRIDE database, was comprehensively interrogated for abnormally glycosylated proteins. Data integration with the Target Score, an algorithm developed in-house, pinpointed the glucose transporter type 1 (GLUT1) as a biomarker of poor prognosis. GLUT1-STn glycoproteoforms were latter identified in tumor tissues in patients facing worst prognosis. Furthermore, healthy human tissues analysis suggested that STn glycosylation provided cancer specificity to GLUT1. In conclusion, STn is a biomarker of worst prognosis in EC and GLUT1-STn glycoforms may be used to increase its specificity on the stratification and targeting of aggressive ESCC forms. 相似文献
7.
Janine Glänzel Arnd Meyer Roman Unger Michael Bräunig Volker Wittstock Steffen Ihlenfeldt 《The International Journal of Advanced Manufacturing Technology》2017,88(5-8):1279-1288
A new interdisciplinary approach is discribed to identifying unknown parameters using an extended version of the known interval bisection method. This developed method is based on the use of finite elements for calibrating the simulation calculation. The resulting thermo-elastic deformations which occur in drilling processes with impaired cooling lubrication are to be used as correction values for tool positioning in the NC control. Based on the strong impact on workpiece temperature of machining, a simulation approach is presented for calculating the temperature fields and their thermo-elastic consequences. In addition, methods are presented to correct these effects. This paper particularly deals with the temperature fields of drilling operations. Special attention is paid to the technique employed for iterative numerical determination of the unknown heat flux η w and heat transfer coefficient \(\bar {\gamma }\) values. Finally, the data obtained from experiments are compared with those achieved by numerical simulation in order to verify the efficiency of simulation and determination of parameters. 相似文献
8.
Matthew F. Johnson Colin R. Thorne Janine M. Castro G. Mathias Kondolf Celeste Searles Mazzacano Stewart B. Rood Cherie Westbrook 《河流研究与利用》2020,36(1):3-12
River management based solely on physical science has proven to be unsustainable and unsuccessful, evidenced by the fact that the problems this approach intended to solve (e.g., flood hazards, water scarcity, and channel instability) have not been solved and long‐term deterioration in river environments has reduced the capacity of rivers to continue meeting the needs of society. In response, there has been a paradigm shift in management over the past few decades, towards river restoration. But the ecological, morphological, and societal benefits of river restoration have, on the whole, been disappointing. We believe that this stems from the fact that restoration overrelies on the same physical analyses and approaches, with flowing water still regarded as the universally predominant driver of channel form and structural intervention seen as essential to influencing fluvial processes. We argue that if river restoration is to reverse long‐standing declines in river functions, it is necessary to recognize the influence of biology on river forms and processes and re‐envisage what it means to restore a river. This entails shifting the focus of river restoration from designing and constructing stable channels that mimic natural forms to reconnecting streams within balanced and healthy biomes, and so levering the power of biology to influence river processes. We define this new approach as biomic river restoration. 相似文献
9.
Bennett JC Krishnamoorthy V Liu S Grout RW Hawkes ER Chen JH Shepherd J Pascucci V Bremer PT 《IEEE transactions on visualization and computer graphics》2011,17(12):1822-1831
We present a new framework for feature-based statistical analysis of large-scale scientific data and demonstrate its effectiveness by analyzing features from Direct Numerical Simulations (DNS) of turbulent combustion. Turbulent flows are ubiquitous and account for transport and mixing processes in combustion, astrophysics, fusion, and climate modeling among other disciplines. They are also characterized by coherent structure or organized motion, i.e. nonlocal entities whose geometrical features can directly impact molecular mixing and reactive processes. While traditional multi-point statistics provide correlative information, they lack nonlocal structural information, and hence, fail to provide mechanistic causality information between organized fluid motion and mixing and reactive processes. Hence, it is of great interest to capture and track flow features and their statistics together with their correlation with relevant scalar quantities, e.g. temperature or species concentrations. In our approach we encode the set of all possible flow features by pre-computing merge trees augmented with attributes, such as statistical moments of various scalar fields, e.g. temperature, as well as length-scales computed via spectral analysis. The computation is performed in an efficient streaming manner in a pre-processing step and results in a collection of meta-data that is orders of magnitude smaller than the original simulation data. This meta-data is sufficient to support a fully flexible and interactive analysis of the features, allowing for arbitrary thresholds, providing per-feature statistics, and creating various global diagnostics such as Cumulative Density Functions (CDFs), histograms, or time-series. We combine the analysis with a rendering of the features in a linked-view browser that enables scientists to interactively explore, visualize, and analyze the equivalent of one terabyte of simulation data. We highlight the utility of this new framework for combustion science; however, it is applicable to many other science domains. 相似文献
10.
Ontology-driven web-based semantic similarity 总被引:1,自引:0,他引:1
David Sánchez Montserrat Batet Aida Valls Karina Gibert 《Journal of Intelligent Information Systems》2010,35(3):383-413
Estimation of the degree of semantic similarity/distance between concepts is a very common problem in research areas such
as natural language processing, knowledge acquisition, information retrieval or data mining. In the past, many similarity
measures have been proposed, exploiting explicit knowledge—such as the structure of a taxonomy—or implicit knowledge—such
as information distribution. In the former case, taxonomies and/or ontologies are used to introduce additional semantics;
in the latter case, frequencies of term appearances in a corpus are considered. Classical measures based on those premises
suffer from some problems: in the first case, their excessive dependency of the taxonomical/ontological structure; in the
second case, the lack of semantics of a pure statistical analysis of occurrences and/or the ambiguity of estimating concept
statistical distribution from term appearances. Measures based on Information Content (IC) of taxonomical concepts combine
both approaches. However, they heavily depend on a properly pre-tagged and disambiguated corpus according to the ontological
entities in order to compute accurate concept appearance probabilities. This limits the applicability of those measures to
other ontologies –like specific domain ontologies- and massive corpus –like the Web-. In this paper, several of the presented
issues are analyzed. Modifications of classical similarity measures are also proposed. They are based on a contextualized
and scalable version of IC computation in the Web by exploiting taxonomical knowledge. The goal is to avoid the measures’
dependency on the corpus pre-processing to achieve reliable results and minimize language ambiguity. Our proposals are able
to outperform classical approaches when using the Web for estimating concept probabilities. 相似文献