Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances

Carriers for targeted delivery and controlled release of poorly water-soluble active substances (PWSAS) are facing three challenges: (a) the encapsulation issues, (b) limitations of PWSAS water solubility, and (c) burst drug release which can be pharmacologically dangerous and economically inefficient. The present study brings a novel strategy for encapsulation and controlled release of PWSAS—caffeine in concentrations which are higher than its maximal water solubility without the possibility of burst effect. The modification of hydrophilic carrier based on poly(methacylic acid) was done using casein and liposomes. To further increase the maximal caffeine loading inside the carrier nicotinamide was used. The release study of the encapsulated PWSAS was elaborated with respect to morphology of the carriers and interactions that could be established between its structural components. The carriers swelling and the release of caffeine and nicotinamide were also investigated depending on caffeine concentration, the presence of different liposomal formulations and the volume ratio of liposomal formulation, in three media with different pH simulating the path of the carrier through the human gastrointestinal tract. The synthesized carriers are promising candidates for encapsulation of PWSAS in concentrations which are higher than its maximal water solubility and for the targeted delivery of those dosages.     

Macrophage Immunomodulation Through New Polymers that Recapitulate Functional Effects of Itaconate as a Power House of Innate Immunity

Itaconate (ITA) is an emerging powerhouse of innate immunity with therapeutic potential that is limited in its ability to be administered in a soluble form. A library of polyester materials that incorporate ITA into polymer backbones resulting in materials with inherent immunoregulatory behavior is developed. Harnessing hydrolytic degradation release from polyester backbones, ITA polymers result in the mechanism specific immunoregulatory properties on macrophage polarization in vitro. In a functional assay, the polymer-released ITA inhibits bacterial growth on acetate. Translation to an in vivo model of biomaterial associated inflammation, intraperitoneal injection of ITA polymers demonstrate a rapid resolution of inflammation in comparison to a control polymer silicone, demonstrating the value of sustained biomimetic presentation of ITA.     

Measuring probe for fast transients monitoring in gas insulatedsubstation

This paper describes the construction of four probes adjusted for fast transient monitoring in 123 kV SF₆ insulated substations. The primary requirement was the ability to monitor without distortion very fast transients containing frequencies up to 200 MHz. The measuring system was tested and calibrated with the help of computer modeling techniques. The verified experimental apparatus was then used for testing and calibrating the measuring probes. During the test, various effects on the measuring system characteristics were analyzed with respect to materials used for the components of the system     

Electrooxidation of CO and CO/H2 mixtures on a Pt-Sn catalyst prepared by an implantation method

A new type of ion implantation technique is used to create a non-equilibrium Pt-Sn(IMP) near-surface alloy with ca. 8.6 at% Sn. The surface composition was determined by low-energy ion-scattering (LEIS). The kinetics of the electrooxidation of CO and 2% CO/H₂ mixtures on Pt-Sn(IMP) is essentially identical to that of Pt₃Sn(110). The fact that any non-equilibrium composition can be easily prepared by this implantation method opens an interesting practical opportunity to create a new Pt-Sn alloy fuel cell catalyst having an otherwise unobtainable surface composition of Sn. This method also appears to have general utility in alloy catalysis as a means of exploring compositions in thermodynamically unfavorable regions of the bulk phase diagram. This revised version was published online in July 2006 with corrections to the Cover Date.     

An image watermarking based on the pdf modeling and quantization effects in the wavelet domain

An image watermarking technique based on the concept of JPEG2000 algorithm is proposed. Biorthogonal wavelet 9/7 transform is used to provide a set of coefficients suitable for watermark embedding. The statistical properties of different subbands are analyzed in order to choose the number of decomposition levels and position of subbands, which will assure the best compromise between the watermark transparency and robustness. The JPEG2000 quantization is applied to avoid insignificant wavelet coefficients, while the remaining ones are used for watermarking. The optimal and blind watermark detection is based on the nonlinear score function and appropriate model of coefficients distribution. The performance of the proposed procedure is tested on examples with various images, showing robustness under different attacks, while maintaining high image quality.     

Bee colony optimization for the p-center problem

Bee colony optimization (BCO) is a relatively new meta-heuristic designed to deal with hard combinatorial optimization problems. It is biologically inspired method that explores collective intelligence applied by the honey bees during nectar collecting process. In this paper we apply BCO to the p-center problem in the case of symmetric distance matrix. On the contrary to the constructive variant of the BCO algorithm used in recent literature, we propose variant of BCO based on the improvement concept (BCOi). The BCOi has not been significantly used in the relevant BCO literature so far. In this paper it is proved that BCOi can be a very useful concept for solving difficult combinatorial problems. The numerical experiments performed on well-known benchmark problems show that the BCOi is competitive with other methods and it can generate high-quality solutions within negligible CPU times.     

Chemical correlates of α-tocopherol (Vitamin E) alteredMalacosoma disstria herbivory inFraxinus pennsylvanica var.Subintegerrinia,green ash

The antioxidant -tocopherol (vitamin E), applied in a basal trunk band to the green ash tree,Fraxinus pennsylvanica var.subintergerrinia, elicited an alteration of foliar feeding byMalacosoma disstria larvae (Lepidoptera: Lasiocampidae). The bioassayed effects were dependent on the dosage of elicitor, the time after elicitation, and the position in the tree. Leaves for chemical analysis were collected from trees receiving two dosages and at two intervals after elicitation. Compounds in the ethyl acetate extractables from the ash tree leaves were separated by TLC and HPLC. TLC separations showed differences in the nonhydrolyzed extractables attributable to elicitor dosage and time after elicitation. TLC-resolved differences were also evident among acid-hydrolyzed samples. HPLC-resolved profiles revealed eight peaks in the nonhydrolyzed extractables that were quantitatively negatively correlated with larval feeding preference between elicited versus control foliage on at least one of the two sampling dates. Results from this study and other investigations reported in the literature indicate that the antioxidant-tocopherol (vitamin E) can function as an environmental-stress elicitor of alterable defensive chemistry in green ash and other plants.     

Structural components in needle-cokes as studied by etching with chromic acid

Structures within commercial calcined needle-cokes are characterized by optical microscopy to reveal optical texture and by scanning electron microscopy before and after etching with chromic acid solution at 400 to 423 K. The needle-cokes exhibit an optical texture of medium and coarse-grained mosaics, acicular flow domains and flow domains. The etching studies indicate that the acicular flow domains are made up of rolled and convoluted lamellae which etch to form laths (needle-like) 3 m across. The mosaics appear when the rolled structures are viewed microscopically sectioned perpendicular to the lamellae. The acicular flow domains appear in longitudinal section. The etching of the flow domains shows that they have a sedimentary structure, 1 to 2 m layer thickness, suggesting that mesophase coalesces within a layer but not between layers. A model is proposed to explain the origin and separation of structures in needle-cokes as created in the delayed coker.     

An exact formula for "Tooth-to-Tooth" permeance

We present a new, completely original exact method to determine the permeance between two opposing iron teeth. This configuration is important because it is often encountered in electrical machines and apparatus. The method is based on conformal mapping. The given "tooth-to-tooth" configuration is mapped into a simpler one, in which the same permeance can be analytically determined. We derive an explicit formula for this permeance, and confirm our results using the finite-element method.     

Determination of tooth cogging force in a hard-disk brushless DC motor

The paper proposes a new method to determine the tooth cogging force in a brushless DC (BLDC) motor which is used in a hard-disk application. This force might be a source of tooth vibrations and motor noise. In the new method, the permanent-magnet (PM) poles are substituted with their equivalent currents. Then, the conformal mapping (CM) method is applied to determine the PM magnetic field. Finally, the cogging force is determined by integrating the magnetic field pressure over the tooth surface. The paper also analyzes the harmonic content of both radial and tangential force components.