Age-related changes in innervation in hypertrophic pyloric stenosis

BACKGROUND/PURPOSE: Recent reports have identified abnormal innervation of the circular muscle layer involving the fine intramuscular nerve fibers in hypertrophic pyloric stenous (HPS). HPS presenting after 3 months of age is rare. The aim of this study was to determine the distribution pattern of nerve fibers in the smooth muscle layers in HPS and correlate this with age at presentation. METHODS: Full-thickness pyloric muscle biopsy specimens were obtained from eight patients with HPS (five age 3 to 5 weeks, two age 3 months, and one age 7 months) and five controls with normal pylorus (age 5 days to 3 years). All specimens were stained with monoclonal antibody to the neural cell adhesion molecule (NCAM) using immunohistochemistry. RESULTS: There were many NCAM-positive nerve fibers in the circular and longitudinal muscle layers in the controls. No NCAM positive nerve fibers were seen in the circular or longitudinal muscle layers in the five cases of HPS in which the patients were less than 5 weeks old. In the two cases in which the patients were 3 months old, occasional NCAM-positive nerve fibers were seen in the circular layer, and moderate numbers of NCAM positive fibers were seen in the longitudinal muscle layers. Moderate numbers of NCAM-positive nerve fibers in the circular muscle layer and many NCAM positive nerve fibers in the longitudinal muscle layers were identified in the 7-month-old HPS patient. CONCLUSIONS: The data suggest that the pyloric muscle lacks innervation in the young HPS infant. Whereas, at 3 months of age the hypertrophied pyloric muscle is partially innervated, and at 7 months of age the pyloric muscle has practically normal innervation.     

The deep waters of land reform: land,water and conservation area claims in Limpopo Province,Olifants Basin,South Africa

Through investigating the reactions of commercial farmers to land and water reforms in the Trichardtsdal-Ofcolaco area, Limpopo Province, Olifants Basin, South Africa, from 1997 to 2006, it is shown that water claims are key to land redistribution processes, and that commercial farmers make strategic use of arguments for nature conservation and ecological stewardship to defend their claims to water. Given these observations, caution is warranted with respect to the implementation of land and water reforms as separate policy packages; it may be more effective to design water and conservation policies as an integral part of land reform programmes.     

Editorial

Abstract

Defining and measuring sustainability is a major challenge. This article argues these limitations need not stop us from trying to identify and value the possible impacts of what we are doing, or are thinking about doing, over time periods much longer than the lives of our investments, or even of the lives of those of us living today. Sustainability is a relative concept that must be applied in an environment undergoing multiple changes, changes that are occurring over different temporal and spatial scales. We depend on our water resource systems for our survival and welfare. Yet no one expects them to be restored to, or survive in, their most productive pristine states in the face of increasing development pressures for land in their watersheds and for water in their streams, rivers, lakes, and aquifers. A continuing task of water resource planners and managers is to identify the multiple impacts and tradeoffs resulting from what we who are living today may wish to do for ourselves and our immediate children and what we can only guess our yet-to-be-born descendants may wish us to do, or not do, for them in some distant future. This task must involve professionals from other disciplines in a context much broader than just water management. Once these impacts and tradeoffs are identified, it is then up to the political process to make choices when they are in conflict. All of us need to be a part of this decision-making process.     

Transforming River Basin Management in South Africa

Abstract

This paper analyzes the transformation of river basin management in South Africa by focusing on the political processes involved in the creation of new water management bodies and irrigation infrastructure in the Lower Komati sub-basin. Institutional reform is described and analyzed in terms of the collaboration theory of Gray (1985). Attention is paid to the absence of mutual collaboration in the water domain through the analysis of three phases that are characteristic of collaborative management: problem setting, direction setting, and structuring. The perceptions and strategies of stakeholders in the change process are informed by the skewed access to land and water, the protracted struggle for redress of historical inequities, the quest for autonomy in water management by commercial farmers, and large political power differentials. This has resulted in differential access to decision making and political influence and in the materialization of these skewed relations in water control technology. The reluctance of stakeholders to explicitly recognize their interdependence and the role of the state as the convener of the change process has hampered the emergence of a shared appreciation of the problems in the water domain. Despite efforts by government to move towards equitable and inclusive water management, little redress of past inequities has taken place, and the majority of small farmers are uninformed and excluded from the change process. This suggests that the proposed Catchment Management Agency will not be representative nor attain equitable water management unless a well-conceived redistribution of water entitlements and land rights is carried out as part of an encompassing program to strengthen political democracy.     

Commercial farmers’ strategies to control water resources in South Africa: an empirical view of reform

This article shows how large-scale commercial farmers, individually and collectively, are responding to land and water reform processes in the Thukela River basin, KwaZulu-Natal, South Africa. With a high degree of innovative agency, commercial farmers have effectively executed four strategies, enabling them to adapt and use their access to resources to neutralize multiple water reform efforts that once promised to be catalysts for inclusive change in the post-apartheid era. It is likely that policy alone will not facilitate the envisioned transformation, if local practices are not sufficiently understood and anticipated by the governmental officials charged with the implementation of water reform processes.     

Evolution of railway network flexibility: The Spanish broad gauge case

The length of the Spanish broad gauge network has decreased in the 1956–2006 period. When looking at different railway maps through this period, it seems that the network is offering fewer and fewer alternatives when a line is cut, that is, the network is becoming less and less flexible. The goal of this article is to prove that the flexibility of the Spanish broad gauge network has decreased substantially in the 1956–2006 period. We have considered the network as a graph (ignoring traditional railway quality indicators such as commercial speed, number of tracks, electrifications, signaling, …) and we have chosen two simple indicators as accurate in this sense: the number of cycles (cycles provide an alternative to reach a station if there is a problem in one line) and the number of stations of intermediate degree. To achieve this, we have developed a piece of software that is an ad hoc extension of Maple’s networks package.     

An information-processing model of the decision to seek professional help.

Despite the presence of quality mental health care in many communities, people tend to avoid seeking help and wind up languishing in their problems unnecessarily. For the professional to better understand how to reach these individuals, an information-processing model is presented that examines the effects of people's interpretation of their environment and their symptoms on their decision to seek mental health services. Using the model as a guide, suggestions are presented for practitioners who wish to provide services to those who are in need of professional help, yet are hesitant to obtain it. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Hirschsprung''s disease: a search for etiology

Expression of proliferating cell nuclear antigen (PCNA) as well as p53, bcl-2 and C-erb B-2 genes protein products on Reed-Sternberg/Hodgkin's (R-S/H) cells was analyzed by immunohistochemistry in 65 patients with Hodgkin's disease (HD). Their significance as markers of clinical malignancy and prognostic factors was evaluated. Positive reaction for PCNA was present in 57 cases (87.7%), for p53 in 42 (64.6%), for bcl-2 in 41 (63.1%), and for C-erb B-2 in 38 cases (58.5%) of HD. The high proliferate PCNA index and high expression of p53 and bcl-2 correlated with poor response to the treatment. Expression of both p53 and bcl-2 oncoproteins negatively influenced overall survival and disease free survival. Indexes of PCNA, p53 and bcl-2 were significantly higher in patients with advanced disease then in early clinical stages. In LP type of HD the lowest indexes of PCNA or bcl-2, and even lack of bcl-2 expression on R-S/H cells were observed. There was no correlation between expression of C-erb B-2 and response to the treatment, time of survival, clinical stage or histopathological types of HD. Statistical analysis let us to the conclusion, that indexes of PCNA, p53 and bcl-2 expression can be taken into consideration as a new prognostic factors in Hodgkin's disease. C-erb B-2 protein expression seems to be of no value for prognosis in HD.     

Feeding colostrum increases circulating insulin-like growth factor I in newborn pigs independent of endogenous growth hormone secretion

Our objective was to examine the influence of feeding and endogenous GH secretion on circulating IGF-I in colostrum-deprived newborn pigs fed colostrum (n = 4), formula (control, n = 4), or water (n = 4). In another four formula-fed pigs, GH was ablated (GRF-A) with two intravenous injections of a GH releasing-factor antagonist (N-Ac-Tyr1,D-Arg2)-GRF(1-29)-NH2. Blood was serially sampled in all pigs to measure plasma IGF-I and GH profiles. Feeding increased plasma IGF-I concentration two- to fourfold and decreased GH secretion. Despite a more than 80% decrease in the plasma GH in GRF-A pigs, the circulating IGF-I concentration was similar to that in control pigs. In colostrum-fed pigs, plasma IGF-I was higher than that in control pigs, despite equal nutrient intake and lower circulating GH. There were no differences in plasma IGF binding protein (IGFBP)-3 levels among the treatment groups. However, the relative abundance of plasma IGFBP-4 was lower, and that of IGFBP-1 higher, in unfed pigs than in any of the three fed groups. The plasma insulin concentration was not different among fed pigs, but it was lower in unfed pigs. Our results indicate that the circulating IGF-I concentration is more dependent on nutrient intake than on GH in newborn pigs, despite relatively high GH concentrations. However, because the nutrient content in the formula was designed to match that of colostrum, a factor other than nutrient intake and GH was responsible for the maximal increase in circulating IGF-I concentration observed in colostrum-fed pigs.