Results of Processing Data from the Automated Seismometric Monitoring System of the Zeya HPP

Power Technology and Engineering - The results of processing annual data of the automated seismometric monitoring system (ASMS) of the Zeya HPP are presented. They are compared with the results of...     

Determination of the level of a substance in a production vessel at high temperature

A radiofrequency method is considered for determining the level of a substance in a vessel at about 1000°C or more that is used in particular for indicating the level of timber plant production waste (wooden fuel) in furnaces of heat generating units. Construction features of these radiofrequency sensors based on sections of long lines are described in detail. __________ Translated from Izmeritel'naya Tekhnika, No. 8. pp. 29–30, August, 2008.     

The Ability of the Nitric Oxide Synthases Inhibitor T1023 to Selectively Protect the Non-Malignant Tissues

Previously, we showed that a nitric oxide synthase (NOS) inhibitor, compound T1023, induces transient hypoxia and prevents acute radiation syndrome (ARS) in mice. Significant efficacy (according to various tests, dose modifying factor (DMF)—1.6–1.9 against H-ARS/G-ARS) and safety in radioprotective doses (1/5–1/4 LD10) became the reason for testing its ability to prevent complications of tumor radiation therapy (RT). Research methods included studying T1023 effects on skin acute radiation reactions (RSR) in rats and mice without tumors and in tumor-bearing animals. The effects were evaluated using clinical, morphological and histological techniques as well as RTOG classification. T1023 administration prior to irradiation significantly limited the severity of acute RSR. This was due to a decrease in radiation alteration of the skin and underlying tissues, and the preservation of the functional activity of cell populations that are critical in the pathogenesis of radiation burn. The DMF values for T1023 for skin protection were 1.4–1.7. Moreover, its radioprotective effect was fully selective to normal tissues in RT models of solid tumors—T1023 reduced the severity of acute RSR and did not modify the antitumor effects of γ-radiation. The results indicate that T1023 can selectively protect the non-malignant tissues against γ-radiation due to hypoxic mechanism of action and potentiate opportunities of NOS inhibitors in RT complications prevention.