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1.
Iason Psilopatis Alexandros Pergaris Kleio Vrettou Stamatios Theocharis Constantinos Troungos 《International journal of molecular sciences》2022,23(7)
Thymic Epithelial Neoplasms (TENs) represent the most common tumors of the thymus gland. Epigenetic alterations are generally involved in initiation and progression of various cancer entities. However, little is known about the role of epigenetic modifications in TENs. In order to identify relevant studies, a literature review was conducted using the MEDLINE and LIVIVO databases. The search terms thymoma, thymic carcinoma, thymic epithelial neoplasm, epigenetics, DNA methylation, HDAC and miRNA were employed and we were able to identify forty studies focused on TENs and published between 1997 and 2021. Aberrant epigenetic alterations seem to be involved in the tumorigenesis of thymomas and thymic carcinomas, with numerous studies reporting on non-coding RNA clusters and altered gene methylation as possible biomarkers in different types of TENs. Interestingly, Histone Deacetylase Inhibitors have shown potent antitumor effects in clinical trials, thus possibly representing effective epigenetic therapeutic agents in TENs. Additional studies in larger patient cohorts are, nevertheless, needed to verify the clinical utility and safety of novel epigenetic agents in the treatment of patients with TENs. 相似文献
2.
Estimation of Width and Depth of the Wetted Soil Volume Under a Surface Emitter,Considering Root Water-Uptake and Evaporation 总被引:1,自引:0,他引:1
A cylindrical flow model that describes local infiltration from a surface point source, by incorporating evaporation and water
extraction by roots, was used to obtain numerical results that were the base for the development and testing of an empirical
method for determining the surface and vertical components of the wetting front. The implementation of the mathematical model
took place against two of the twelve USDA soil classes, using three water application rates for each one. The empirical methodology
consisted of two simple, time dependent empirical relationships: a power law for the stage of the infiltration, which was
applied in both directions and a polynomial for the stage after the end of the irrigation, applied only for the vertical component,
to account for percolation losses. The statistical criteria used for the evaluation of the method showed good agreement between
the numerical results and the values calculated by the empirical relationships. Based on the limited availability of necessary
experimental data for detailed analysis of multidimensional transient infiltration, the introduction of such an empirical
model, as a design tool for trickle irrigation systems, may contribute to the selection of the optimum application rate and
lateral spacing. 相似文献
3.
Argyris C. Hadjimichael Alexandros Pergaris Angelos Kaspiris Athanasios F. Foukas Stamatios E. Theocharis 《International journal of molecular sciences》2021,22(21)
Soft tissue and bone sarcomas represent a group of aggressive neoplasms often accompanied by dismal patient prognosis, especially when distant metastases are present. Moreover, effective treatment can pose a challenge, as recurrences are frequent and almost half of patients present with advanced disease. Researchers have unveiled the molecular abnormalities implicated in sarcomas’ carcinogenesis, paving the way for novel treatment strategies based on each individual tumor’s characteristics. Therefore, the development of new techniques aiding in early disease detection and tumor molecular profiling is imperative. Liquid biopsy refers to the sampling and analysis of patients’ fluids, such as blood, to identify tumor biomarkers, through a variety of methods, including qRT-PCR, qPCR, droplet digital PCR, magnetic microbeads and digital PCR. Assessment of circulating tumor cells (CTCs), circulating free DNA (ctDNA), micro RNAs (miRs), long non-coding RNAs (lncRNAs), exosomes and exosome–associated proteins can yield a plethora of information on tumor molecular signature, histologic type and disease stage. In addition, the minimal invasiveness of the procedure renders possible its wide application in the clinical setting, and, therefore, the early detection of the presence of tumors. In this review of the literature, we gathered information on biomarkers assessed through liquid biopsy in soft tissue and bone sarcoma patients and we present the information they can yield for each individual tumor type. 相似文献
4.
Panagiotis Sarantis Alexandros Bokas Adriana Papadimitropoulou Evangelos Koustas Stamatios Theocharis Pavlos Papakotoulas Dimitrios Schizas Alexandros Papalampros Evangelos Felekouras Athanasios G. Papavassiliou Michalis V. Karamouzis 《International journal of molecular sciences》2021,22(13)
Pancreatic Cancer (PC) is recognized as a highly thrombogenic tumor; thus, low-molecular-weight heparin (LMWH) such as tinzaparin is routinely used for PC patients. On the basis of combinatorial therapy approaches to treat highly malignant and refractory cancers such as PC, we hypothesized that tinzaparin can augment the effectiveness of traditional chemotherapeutic drugs and induce efficient antitumor activity. PANC-1 and MIAPaCa-2 were incubated alone or in combination with tinzaparin, nab-paclitaxel and gemcitabine. In vivo evaluation of these compounds was performed in a NOD/SCID mouse using a model injected with PANC-1. Tinzaparin enhances the anti-tumor effects of nab-paclitaxel and gemcitabine in mtKRAS PC cell lines via apoptosis in in vitro experiments. The triple combination power acts through the induction of apoptosis, reduction of the proliferative potential and angiogenesis; hence, contributing to a decrease in tumor volume observed in vivo. The triple regimen provided an extra 24.3% tumor reduction compared to the double combination (gemcitabine plus nab-paclitaxel). Combinatorial strategies can create novel therapeutic approaches for the treatment of patients with PC, achieving a better clinical outcome and prolonged survival. Further prospective randomized research is needed and the investigation of various concentrations of tinzaparin above 150 UI/Kg, would potentially provide a valuable synergistic effect to the conventional therapeutic compounds. 相似文献
5.
Argyris C. Hadjimichael Alexandros Pergaris Angelos Kaspiris Athanasios F. Foukas Stefania Kokkali Gerasimos Tsourouflis Stamatios Theocharis 《International journal of molecular sciences》2022,23(9)
Musculoskeletal sarcomas represent rare heterogenous malignancies of mesenchymal origin that can be divided in two distinct subtypes, bone and soft tissue sarcomas. Current treatment options combine the surgical excision of local tumors and multidrug chemotherapy to prevent metastatic widespread disease. Due to the grim prognosis that usually accompanies such tumors, researchers have attempted to shed light on the molecular pathways implicated in their pathogenesis in order to develop novel, innovative, personalized therapeutic strategies. Erythropoietin-producing human hepatocellular receptors (EPHs) are tyrosine-kinase transmembrane receptors that, along with their ligands, ephrins, participate in both tumor-suppressive or tumor-promoting signaling pathways in bone and soft tissue sarcomas. The EPH/ephrin axis orchestrates cancerous processes such as cell–cell and cell–substrate adhesion and enhances the remodeling of the intracellular cytoskeleton to stimulate the motility and invasiveness of sarcoma cells. The purpose of our study was to review published PubMed literature to extract results from in vitro, in vivo and clinical trials indicative of the role of EPH/ephrin signaling in bone and soft tissue sarcomas. Based on these reports, significant interactions between the EPH/ephrin signaling pathway and a plethora of normal and abnormal cascades contribute to molecular mechanisms enhancing malignancy during sarcoma progression. In addition, EPHs and ephrins are prospective candidates for diagnostic, monitoring and therapeutic purposes in the clinical setting against bone and soft tissue sarcomas. 相似文献
6.
Christos Masaoutis Kostas Palamaris Stefania Kokkali Georgia Levidou Stamatios Theocharis 《International journal of molecular sciences》2022,23(14)
Thymic Epithelial Tumors (TETs) represent a rare tumor family, originating from the epithelial component of the thymus gland. Clinicopathologically, they are segregated into six major subtypes, associated with distinct histological features and clinical outcomes. Their emergence and evolution are accompanied by the generation of a complex tumor microenvironment (TME), dominated by phenotypically and functionally divergent immune cellular subsets, in different maturation states and in analogies that vary significantly among different subtypes. These heterogenous leukocyte populations exert either immune-permissive and tumor-suppressive functions or vice versa, and the dynamic equilibrium established among them either dictates the tumor immune milieu towards an immune-tolerance state or enables the development of a productive spontaneous tumoricidal response. The immunologically “hot” microenvironment, defining a significant proportion of TETs, makes them a promising candidate for the implementation of immune checkpoint inhibitors (ICIs). A number of phase I and II clinical trials have already demonstrated significant, type-specific clinical efficacy of PD-L1 inhibitors, even though substantial limitations in their utilization derive from their immune-mediated adverse effects. Moreover, the completed clinical studies involved relatively restricted patient samples and an expansion in the enrolled cohorts is required, so that more trustworthy conclusions regarding the benefit from ICIs in TETs can be extracted. 相似文献
7.
Despoina Pouloudi Aristoteles Sotiriadis Margarita Theodorakidou Panagiotis Sarantis Alexandros Pergaris Michalis V. Karamouzis Stamatios Theocharis 《International journal of molecular sciences》2020,21(24)
Salivary gland carcinomas (SGCs) represent a group of rare tumors, with complete surgical resection being the main treatment option. Therapeutic armory for cases of locally aggressive, recurrent, and/or metastatic SGCs, though, remains poor since they exhibit high rates of resistance to systematic therapy. Angiogenesis is considered one of the contemporary hallmarks of cancer and anti-angiogenic factors have already been approved for the treatment of several cancer types. This review aims to summarize, in a histotype-specific manner, the most current available data on the angiogenic factors implicated in SGC angiogenesis, in order to highlight the differences between the most common SGC histotypes and the factors that may have a potential role as therapeutic targets. 相似文献
8.
Stamatios Elmaloglou Konstantinos X. Soulis Nicholas Dercas 《Water Resources Management》2013,27(12):4131-4148
One of the most important aspects of planning and management of a drip irrigation system is the determination of the soil moisture patterns formed under the emitter. In the present study soil water dynamics under surface drip irrigation from equidistant line sources are investigated using a simulation model, which combines hysteresis in the soil water characteristic curve, evaporation from the soil surface, and water extraction by roots. In this model a two-dimensional distribution of roots as well as a more rational way for the temporal distribution of the daily potential evapotranspiration are also incorporated. Soil water distribution patterns for two soil types (loamy sand, silt loam), two discharge rates (2 and 4 l m?1 h?1), two irrigation depths (30 and 40 mm), and two drip line sources spacing patterns (60 and 80 cm) are investigated. The numerical results showed that the soil water dynamics mainly depend on the soil hydraulic properties, the irrigation depth, and the drip line sources spacing. The results also showed that the irrigation efficiency and the actual evaporation decrease when the irrigation dose or the distance between the line sources increases. By contrast, the deep percolation increases when the irrigation dose or the distance between the line sources increases. 相似文献
9.
Mexis SF Riganakos KA Kontominas MG 《Journal of the science of food and agriculture》2011,91(4):634-649
BACKGROUND: The present study investigated the effect of irradiation, active and modified atmosphere packaging, and storage conditions on quality retention of raw, whole, unpeeled almonds. Almond kernels were packaged in barrier and high‐barrier pouches, under N2 or with an O2 absorber and stored either under fluorescent lighting or in the dark at 20 °C for 12 months. Quality parameters monitored were peroxide value, hexanal content, colour, fatty acid composition and volatile compounds. Of the sensory attributes colour, texture, odour and taste were evaluated. RESULTS: Peroxide value and hexanal increased with dose of irradiation and storage time. Irradiation resulted in a decrease of polyunsaturated and monounsaturated fatty acids during storage with a parallel increase of saturated fatty acids. Volatile compounds were not affected by irradiation but increased with storage time indicating enhanced lipid oxidation. Colour parameters of samples remained unaffected immediately after irradiation. For samples packaged under a N2, atmosphere L* and b* values decreased during storage with a parallel increase of value a* resulting to gradual product darkening especially in irradiated samples. CONCLUSION: Non‐irradiated almonds retained acceptable quality for ca. 12 months stored at 20 °C with the O2 absorber irrespective of lighting conditions and packaging material oxygen barrier. The respective shelf life for samples irradiated at 1.0 kGy was 12 months packaged in PET‐SiOx//LDPE irrespective of lighting conditions and 12 months for samples irradiated at 3 kGy packaged in PET‐SiOx//LDPE stored in the dark. Copyright © 2010 Society of Chemical Industry 相似文献
10.
Lizarraga L Souentie S Boreave A George C D'Anna B Vernoux P 《Environmental science & technology》2011,45(24):10591-10597
A Diesel Particulate Filter (DPF) regeneration process was investigated during aftertreatment exhaust of a simulated diesel engine under the influence of a Diesel Oxidation Catalyst (DOC). Aerosol mass spectrometry analysis showed that the presence of the DOC decreases the Organic Carbon (OC) fraction adsorbed to soot particles. The activation energy values determined for soot nanoparticles oxidation were 97 ± 5 and 101 ± 8 kJ mol(-1) with and without the DOC, respectively; suggesting that the DOC does not facilitate elementary carbon oxidation. The minimum temperature necessary for DPF regeneration was strongly affected by the presence of the DOC in the aftertreatment. The conversion of NO to NO(2) inside the DOC induced the DPF regeneration process at a lower temperature than O(2) (ΔT = 30 K). Also, it was verified that the OC fraction, which decreases in the presence of the DOC, plays an important role to ignite soot combustion. 相似文献