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Intraneural injection of 10-20 x 10(6) viable Mycobacterium leprae into the sciatic nerve of normal, unsensitized, Swiss white mice gives rise to a tuberculoid type of granulomatous response in 2 weeks. The same dose of viable M. leprae when injected into the sciatic nerves of unsensitized immunosuppressed mice (T200 x 5R) elicited a macrophage response. When macrophages were systemically immobilized using an intraperitoneal injection of silica quartz dust in normal mice, the lesion produced was of the lepromatous type, suggesting a role for the macrophage in the induction of the tuberculoid type of granulomatous response. In all of these in situ experiments, M. leprae failed to enter the Schwann cells.  相似文献   
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Chemiluminescence (CL) of the systems containing Eu2+ or HCO3 ions and hydrogen peroxide was studied. The kinetic curves and CL emission spectra of the systems were discussed. The emission spectrum of the system containing carbonates revealed two emission maxima: the first directly after initiation of the reaction by hydrogen peroxide and the second in several seconds after the first. On the basis of the characteristic bands in the CL spectrum the emitters in the system Eu2+/HCO3/H2O2 were identified as: excited Eu3+ ions and excited products of carbonate decomposition. The emission bands for λ=600 and 420 nm appeared in a time distance of a few ten seconds.  相似文献   
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The one-step metal promoted reaction between salicylaldehyde and 4-methyl-1,3-phenylenediamine in the presence of lanthanum(III) or gadolinium(III) nitrate yields new salicylaldimine complexes containing N,N′-bis(salicylidene)-4-methyl-1,3-phenylenediamine as a result of the [2 + 1] Schiff base condensation. The crystal structure of the gadolinium complex reveals a dinuclear species with four unionized ligands coordinating in the monodentate and bridging bidentate fashion, using exclusively the oxygens as donor atoms with the nitrogen atoms not being involved in coordination. The coordination number of nine is achieved by involving three bidentate nitrate counterions in the coordination sphere.  相似文献   
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The paper provides comparison of three different approaches to on-line tuning of generalized adaptive notch filters (GANFs) — the algorithms used for identification/tracking of quasi-periodically varying dynamic systems. Tuning is needed to adjust adaptation gains, which control tracking performance of GANF algorithms, to the unknown and/or time time-varying rate of system nonstationarity. Two out of three compared approaches are classical solutions — the first one incorporates sequential optimization of adaptation gains while the second one is based on the concept of parallel estimation. The main contribution of the paper is that it suggests the third way — it shows that the best results can be achieved when both approaches mentioned above are combined in a judicious way. Such joint sequential/parallel optimization preserves advantages of both treatments: adaptiveness (sequential approach) and robustness to abrupt changes (parallel approach). Additionally the paper shows how, using the concept of surrogate outputs, one can extend the proposed single-frequency algorithm to the multiple frequencies case, without falling into the complexity trap known as the “curse of dimensionality”.  相似文献   
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This paper presents definitions and basic properties of uncertain variables and shows how they may be applied to the analysis and decision making in static systems with unknown parameters in their mathematical models. The unknown parameters are assumed to be uncertain variables described by certainty distributions given by an expert. Two versions of the uncertain variables are described. The uncertain variable in the first version may be considered as a special case of the fuzzy number with a specific interpretation. Two forms of systems are considered in the paper: a system described by a function (functional system) and a system described by a relation (relational system). In both cases the statements and general solutions of the analysis and decision problems are presented. Simple examples illustrating the application of the uncertain variables are included.  相似文献   
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Methods of electron microscopy and X-ray diffraction have been used to investigate structural and phase transformations in the aluminum alloy of grade A2024 (Al–4.5 Cu–1.37 Mg–0.61 Mn–0.07 Si–0.27 Fe–0.02 Zn–0.02 Ti (wt %)) after aging and deformation by shear under high quasi-static pressure. It has been shown that the combination of two-stage aging with megaplastic deformation leads to the refinement of the structure to a nanolevel and to strengthening of the alloy (to an increase in the microhardness to 3000 MPa). The values of true deformation at which the deformation-induced dissolution of the particles of the strengthening S phase occurs have been determined.  相似文献   
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