利用核函数法中的自适应带宽同时对一维空间两个储集层属性参数进行粗化

在多孔介质流体流动模拟中,应用网格粗化方法必须在保留重要储集层参数的空间分布的前提下,首先利用大网格粗化原始地质模型(尤其是孔隙型介质),并用数值方法求解。提出了根据属性参数的空间分布、以核函数的自适应带宽为基础的网格粗化新方法,该方法既减少了网格数量,同时也保留原始精细模型的主要非均质性特征。该方法的关键点在于可以同时对两种储集层属性参数进行网格粗化。首先计算每个储集层属性参数的带宽量或最优门槛值并得到粗化结果,然后根据最大带宽和最小带宽采用两种不同的方法对两个属性参数同时粗化。现在已经能够实现利用不同方法建立储集层两个属性参数的最终粗化模型,不同方法的网格单元数和网格位置都相同。最小带宽法的粗化误差小于最大带宽法。图6表1参29     

Mesenchymal stem cells transplantation attenuates experimentally induced brain injury after neonatal hypoxia by different two routes of administrations

The neonatal hypoxic–ischemic encephalopathy (HIE) is an important cause of neurological morbidity and mortality in neonates. Cell therapy is considered a promising method for treating severe neurological disorders such as this one. Stem cells have the capacity for self-renewal and differentiation into certain cell lineages. The present study was aimed to find out the most beneficial route of bone marrow-derived mesenchymal stem cells (BMSCs) administration for the attenuation of experimentally induced HIE in neonatal rats. Sixty neonatal rats were divided randomly into four groups. Group 1: control group. Group 2: rats were exposed to bilateral ligation of cephalic arteries. Group 3: rats were exposed to bilateral ligation of cephalic arteries and then underwent intravenous (IV) BMSC injection. Group 4: rats were exposed to bilateral ligation of cephalic arteries and then underwent intracerebroventricular (ICV) BMSC injection. The animals were evaluated by (a) neurobehavioral tests; (b) histopathology, i.e., histological and immunohistochemical studies; and (3) gene expression studies. The BMSC treated groups (3 and 4) showed improvement in neurobehavioral tests, histopathological studies, and gene expression, as compared to non-injected lesioned rats (Group 2) with better improvement in Group 4 (ICV injections) than in Group 3 (IV injections).     

On nega-binary sign detectors

A circuit for detecting sign and zero magnitude w proposed. The proposed ceil is a priority detector and simpler than cells already proposed.     

Isolation of stem cells from adult rat kidneys

The kidney has an inherent ability for recovery and regeneration following acute damage. However, there has been much contention as to the source of regenerating renal cells. The aim of this study was to isolate and characterize these cells. Normal rat kidneys were minced and cells were isolated with collagenase I and were cultured in an expansion medium. Adherent cells were isolated and expanded for more than 120 days in vitro. These cells had the potential of trans-lineage differentiation into neural cells, adipocytes and osteocytes. These cells also expressed Nucleostemin, Cyclin D1, Notch1 and Survivin which are commonly expressed in stem cells. The results of the current work show that the adult kidney contains a population of multipotent stem cells.