Interaction study between drugs and some synthetic nanoporous composites

In this work MCM-41, MCM-41/NaY and Clinoptilolite/MCM-41/NaY composites that have CTMABr (N-cethyl-N,N, and N-trimethyl Ammonium Bromide) were prepared and characterized with XRD, SEM and FT-IR. Also, incorporation of two model drugs (sulfamethoxazole and metronidazole) with these composite were considered. The drug adsorption assays showed that three composites adsorb considerable amount of drugs, in particular sulfamethoxazole which was evaluated by UV spectroscopy. The results show that we have more adsorption of sulfamethoxazole for MCM-41/NaY that there is a direct relationship exists between the amounts of surfactant per gram of composite. TGA shows that the composites are more stable thermally when the ad micelles contain sulfamethoxazole in their interior. The results of adsorption of sulfamethoxazole showed that approximately 70% of drug was released from MCM-41/NaY-sulfamethoxazole system after about 24 h.     

Fingerprinting Based Indoor Localization Considering the Dynamic Nature of Wi-Fi Signals

Current localization techniques in outdoors cannot work well in indoors. Wi-Fi fingerprinting technique is an emerging localization technique for indoor environments. However in this technique, the dynamic nature of WiFi signals affects the accuracy of the measurements. In this paper, we use affinity propagation clustering method to decrease the computation complexity in location estimation. Then, we use the least variance of Received Signal Strength (RSS) measured among Access Points (APs) in each cluster. Also we assign lower weights to altering APs for each point in a cluster, to represent the level of similarity to Test Point (TP) by considering the dynamic nature of signals in indoor environments. A method for updating the radio map and improving the results is then proposed to decrease the cost of constructing the radio map. Simulation results show that the proposed method has 22.5% improvement in average in localization results, considering one altering AP in the layout, compared to the case when only RSS subset sampling is considered for localization because of altering APs.

     

Heating/Drying Using Particulate Medium : A Review Part I. General and Heat transfer parameters

ABSTRACT

This paper presents an Overview of particulate medium drying and heat treating of cereal grains. While the conventional air drying of grains is well documented, studies on the drying of grains using heated granular medium do not appear to exist. The scientific study of the different aspects of drying with a heated granular medium began in the early 1970's. Progress on the utilization of particle-to-particle heat transfer was slow as evidenced by the fact that there is no commercial dryer using the method as of today.

The first section of this paper deals with conduction heating and how it led to the use of granular medium in heating the grain. Starting with the earliest work on conduction heating reported by Kelly ( 1939), the developments in the heating of grain using granular media is discussed. For decades since Kelly's report, work in the subject area dealt mostly with the theoretical aspects of solid-to-solid heat transfer. Thus, in the succeeding section of the paper, heat transfer parameters and mechanisms involved in the process are thoroughly investigated.     

Direct and Residual Effects of Water Deficit Stress,Different Sources of Silicon and Plant-Growth Promoting Bacteria on Silicon Fractions in the Soil

Silicon - Silicon (Si) and plant growth promoting bacteria (PGPB) can effectively reduce the negative effects of water deficit stress and augment plant growth. Few studies have simultaneously...     

Modified preparation of HDPE/clay nanocomposite by in situ polymerization using a metallocene catalyst

In this study, preparation of high-density polyethylene (HDPE)/clay nanocomposite by in situ polymerization of ethylene using a zirconocene catalyst (bis-(cyclopentadienyl) zirconium dichloride (Cp₂ZrCl₂)) was investigated. To obtain higher efficiency, nanoclay particles (Na-montmorillonite) were modified by ammonia (NH₃), NH₃/methylaluminoxane (MAO), NH₃/dodecylamine (DDA), and NH₃/MAO/DDA systems. The results showed that the activity of the catalyst supported on the nanoclay particles modified by NH₃/MAO (762 g_p/mmol (Zr) t [atm]) was higher than that of the one supported on the unmodified nanoclay as well as the other prepared modified nanoclay-supported catalyst systems. The catalyst activities versus MAO concentration in NH₃/MAO treatment system and versus DDA concentration in NH₃/DDA system showed a maximum. Unexpectedly, a very low catalyst activity (180 g_p/mmol(Zr) t [atm]) was obtained using NH₃/MAO/DDA system. X-ray diffraction patterns showed that the HDPE/clay nanocomposites prepared by NH₃/MAO/DDA treatment system had less intercalated structure. Fourier transform infrared (FTIR) spectroscopy confirmed that water molecules of the nanoclay particles were reduced by NH₃ modification. DSC results revealed that crystallinity of the HDPE/clay nanocomposites increased with the modification of the nanoclay particles. The maximum degree of crystallinity of 80.8% was obtained for HDPE/clay nanocomposites prepared by the nanoclay modified by NH₃. In addition, nanoclay modification with NH₃, NH₃/MAO, and NH₃/DDA systems resulted in higher thermal decomposition temperature (~30 °C higher than 480 °C of the unmodified one). Such increase was not observed for the NH₃/MAO/DDA treatment system. Dynamic mechanical analysis showed an increase in the elastic modulus of the nanocomposite samples prepared by modified nanoclay particles, as well. Meanwhile, modification of the nanoclay particles by NH₃ led to the highest elastic behavior compared to the other modification systems. It was about 4.6 GPa which was 28% higher than the elastic modulus of the nanocomposite prepared by unmodified nanoclay particles.     

Simultaneous control of rod length and pore diameter of SBA-15 for PPL loading

Mesoporous silica materials are attractive materials for immobilizing enzymes because of their well-ordered structures, large surface area are pore volume. Diffusion of large enzyme molecules such as porcine pancreatic lipase (PPL) through the lengthy channels of MPS takes place too slowly. Therefore, the squat of the enzyme at the pore mouth entrance, actually makes the rest of the channel useless. In this study, to overcome this problem, synthesis parameters of SBA-15 were changed, since along with pore diameter increasing, the mesochannel length becomes shorter. The main point to obtain a well-ordered 2D hexagonal pore structure was the pre-hydrolysis of tetraethyl orthosilicate (TEOS) before the addition of 1,3,5-trimethyl benzene as a micelle swelling agent. Due to the strong effect of zirconium in changing the morphology of SBA-15 particles, we modified SBA-15 in the presence of a small amount of ZrOCl₂ in the synthesis solution under acidic conditions. As a result, mesochannel length of SBA-15-Zr was shortened from 600 to <200 nm. The morphology of mesoporous silica was also changed from rod-like to platelet, because of the accelerating effect of Zr(IV) on the self-assembly rate of P123 and TEOS condensation. Characteristic results conducted by low angle XRD, high resolution transmission electron microscopy and nitrogen adsorption, confirmed tuning effect of Zr(IV) in SBA-15. Furthermore, it was shown that the number of pore entrances increases with decreasing the length of SBA-15 mesochannels, leading to obvious improvement of enzyme uptake. PPL has been successfully immobilized in the mesoporous channels of SBA-15-Zr. The total amount of lipase adsorbed on the mesoporous SBA-15-Zr was measured by thermal gravimetric analysis. The largest PPL adsorption capacity was 784 mg/g belonging to the SBA-15-Zr with the length of 150 nm and the mean pore size diameter of 9.22 nm.     

Some aspects of fluidized bed combustion of paddy husk

Some agricultural wastes—for example, bagasse, paddy husk, etc.—are frequently used as fuels, paddy husk appearing, in particular, to be quite suitable for fluidized bed combustion. The conventional method of combustion of paddy husk in grate-type furnaces is slow and inefficient.

This paper reports certain aspects of the fluidized bed combustion of paddy husk. Fluidized bed combustion was carried out by feeding husk in a bed of sand particles. The unexpanded bed height was 10 cm and the size of the sand particles, 351–420 μm. The superficial velocity of the ambient fluidization air through the bed ranged from 11·1 to 22·2 m/min.

A combustion intensity of about 530 kg/h/m² of distributor area could be achieved. This is about 7·5 times higher than the maximum combustion intensity possible in a grate-type furnace per unit grate area. The efficiency of combustion, which ranged from 81 to 98 per cent was found to increase with the air flow rate. There was significant carry-over of inert sand particles from the bed under conditions of high air flow rate.

Combustion intensity increased as the bed height rose from 10 cm to 15 cm, but increased sand entrainment also occurred.     

Supplementation effects of pomegranate by-products on oxidative status,metabolic profile,and performance in transition dairy cows

Recent studies demonstrated a high antioxidant capacity for pomegranate components due to their rich bioactive compounds, such as conjugated fatty acids and phenolics. The objective of the present study was, therefore, to assess whether pomegranate seed or pomegranate seed pulp (peel + seed) supplementation could be effective to improve antioxidant status, and hence metabolic profile and performance in periparturient dairy cows. After a 1-wk pretreatment period, Holstein cows (primiparous n = 12, multiparous n = 18) were assigned to 3 dietary treatments from 25 d before expected calving through 25 d postcalving. The dietary treatments included (1) control (CON); (2) diet supplemented with pomegranate seeds (PS; 400 g/cow per day); and (3) diet supplemented with pomegranate seed pulp (PSP; 400 g of seeds/cow per day + 1200 g of peels/cow per day). Compared with CON, supplementation with either PS or PSP had no effects on dry matter intake, rumen fermentation, and plasma concentrations of cholesterol, total protein, globulin, and aspartate amino transferase, but enhanced plasma total antioxidant activity, and lowered triacylglycerol, free fatty acids (FFA), and β-hydroxybutyrate at both pre- and postpartum periods. Plasma concentration of glucose, albumin, malondialdehyde (MDA) and blood superoxide dismutase (SOD) activity were not affected by dietary treatments at prepartum, whereas SOD activity increased and glucose, albumin, MDA, and FFA-to-albumin ratio decreased by feeding both by-products at postpartum period. In contrast to PS, supplementing PSP resulted in a greater decrease in plasma glucose and triacylglycerol concentration and higher increase in SOD activity. Energy- and fat-corrected milk yields were higher in cows fed PSP diet compared with those fed CON or PS diets, but content of milk fat, protein, and lactose were similar across the dietary treatments. These findings indicated that dietary pomegranate by-products supplementation, in particular PSP, could improve antioxidant status, which was associated with a decline in lipid oxidation (FFA and β-hydroxybutyrate) and peroxidation (MDA) and an enhancement in glucose utilization as well as fat-corrected milk yield.     

Nanoelectromechanical Chip (NELMEC) Combination of Nanoelectronics and Microfluidics to Diagnose Epithelial and Mesenchymal Circulating Tumor Cells from Leukocytes

An integrated nano‐electromechanical chip (NELMEC) has been developed for the label‐free distinguishing of both epithelial and mesenchymal circulating tumor cells (ECTCs and MCTCs, respectively) from white blood cells (WBCs). This nanoelectronic microfluidic chip fabricated by silicon micromachining can trap large single cells (>12 µm) at the opening of the analysis microchannel arrays. The nature of the captured cells is detected using silicon nanograss (SiNG) electrodes patterned at the entrance of the channels. There is an observable difference between the membrane capacitance of the ECTCs and MCTCs and that of WBCs (measured using SiNG electrodes), which is the key indication for our diagnosis. The NELMEC chip not only solves the problem of the size overlap between CTCs and WBCs but also detects MCTCs without the need for any markers or tagging processes, which has been an important problem in previously reported CTC detection systems. The great conductivity of the gold‐coated SiNG nanocontacts as well as their safe penetration into the membrane of captured cells, facilitate a precise and direct signal extraction to distinguish the type of captured cell. The results achieved from epithelial (MCF‐7) and mesenchymal (MDA‐MB231) breast cancer cells circulated in unprocessed blood suggest the significant applications for these diagnostic abilities of NELMEC.