Thrombospondin-1 CD47 Signalling: From Mechanisms to Medicine

Recent advances provide evidence that the cellular signalling pathway comprising the ligand-receptor duo of thrombospondin-1 (TSP1) and CD47 is involved in mediating a range of diseases affecting renal, vascular, and metabolic function, as well as cancer. In several instances, research has barely progressed past pre-clinical animal models of disease and early phase 1 clinical trials, while for cancers, anti-CD47 therapy has emerged from phase 2 clinical trials in humans as a crucial adjuvant therapeutic agent. This has important implications for interventions that seek to capitalize on targeting this pathway in diseases where TSP1 and/or CD47 play a role. Despite substantial progress made in our understanding of this pathway in malignant and cardiovascular disease, knowledge and translational gaps remain regarding the role of this pathway in kidney and metabolic diseases, limiting identification of putative drug targets and development of effective treatments. This review considers recent advances reported in the field of TSP1-CD47 signalling, focusing on several aspects including enzymatic production, receptor function, interacting partners, localization of signalling, matrix-cellular and cell-to-cell cross talk. The potential impact that these newly described mechanisms have on health, with a particular focus on renal and metabolic disease, is also discussed.     

Evaluation of reservoir sedimentation using data driven techniques

The sedimentation is a pervasive complex hydrological process subjected to each and every reservoir in world at different extent. Hydrographic surveys are considered as most accurate method to determine the total volume occupied by sediment and its distribution pattern in a reservoir. But, these surveys are very cumbersome, time consuming and expensive. This complex sedimentation process can also be simulated through the well calibrated numerical models. However, these models generally are data extensive and require large computational time. Generally, the availability of such data is very scarce. Due to large constraints of these methods and models, in the present study, data driven approaches such as artificial neural networks (ANN), model trees (MT) and genetic programming (GP) have been investigated for the estimation of volume of sediment deposition incorporating the parameters influenced it along with conventional multiple linear regression data driven model. The aforementioned data driven models for the estimation of reservoir sediment deposition were initially developed and applied on Gobindsagar Reservoir. In order to generalise the developed methodology, the developed data driven models were also validated for unseen data of Pong Reservoir. The study depicted that the highly nonlinear models ANN and GP captured the trend of sediment deposition better than piecewise linear MT model, even for smaller length datasets.     

Multi‐band pattern reconfigurable Yagi‐Uda antenna

In this study, novel designs of single‐band and tri‐band pattern reconfigurable antennas are proposed. The design of single‐band pattern reconfigurable antenna is accomplished by the use of varactor diodes with the parasitic elements placed on both sides of the driven conventional printed dipole antenna. By tuning the capacitance of varactor, the antenna operates in four different configurations of radiation pattern which include bi‐directional end‐fire, broadside, and uni‐directional end‐fire radiation patterns. The tri‐band pattern reconfigurable antenna design is achieved by the use of parasitic elements on both sides of a tri‐band driven dipole antenna. Dual‐band LC resonators are used as loading elements along the arms of printed dipole to get two lower order modes in addition to the reference dipole mode, resulting in a triband operation of the driven element. The electrical lengths of the parasitic elements with respect to the tri‐band driven element are controlled by suitably embedding varactor and PIN diodes with them. The proposed tri‐band antenna operates in ten different configurations of radiation patterns in the three operating bands. Fully functional prototypes of single‐band and tri‐band pattern reconfigurable antennas along with the DC bias networks have been fabricated to validate the results obtained in simulation.     

Effect of temperature and α-irradiation on gas permeability for polymeric membrane

In the present study the polyethersulphone (PES) membranes of thickness (35 ±2) μm were prepared by solution cast method. The permeability of these membranes was calculated by varying the temperature and by irradiation of α ions. For the variation of temperature, the gas permeation cell was dipped in a constant temperature water bath in the temperature range from 303–373 K, which is well below the glass transition temperature (498 K). The permeability of H₂ and CO₂ increased with increasing temperature. The PES membrane was exposed by a-source (₉₅Am₂₄₁) of strength (1 μ Ci) in vacuum of the order of 10⁻⁶ torr, with fluence 2.7 × 10⁷ ions/cm². The permeability of H₂ and CO₂ has been observed for irradiated membrane with increasing etching time. The permeability increases with increasing etching time for both gases. There was a sudden change in permeability for both the gases when observed at 18 min etching. At this stage the tracks are visible with optical instrument, which confirms that the pores are generated. Most of pores seen in the micrograph are circular cross-section ones.     

Effect of hydrophilic and hydrophobic polymers on permeation of S-amlodipine besylate through intercalated polymeric transdermal matrix: 3(2) designing,optimization and characterization

Objective: Innovation in material science has made it possible to fabricate a pharmaceutical material of modifiable characteristics and utility, in delivering therapeutics at a sustained/controlled rate. The objective of this study is to design and optimize the controlled release transdermal films of S-Amlodipine besylate by intercalating hydrophilic and hydrophobic polymers.

Methods: 3(2) factorial design and response surface methodology was utilized to prepare formulations by intercalating the varied concentration of polymers(A) and penetration enhancer(B) in solvent. The effect of these independent factors on drug release and flux was investigated to substantiate the ex-vivo, stability and histological findings of the study.

Results: FTIR, DSC revealed the compatibility of drug with polymers; however, the semicrystallinity in drug was observed under PXRD. SEM micrographs showed homogeneous dispersion and entanglement of drug throughout the matrix. Results from the permeation study suggested the significant effect of factors on the ex vivo permeation of drug. It was observed that drug release was found to be increased with an increase in hydrophilic polymer concentration and PE. The formulations having polymers (EC:PVPK-30) at 7:3 showed maximum drug release with highest flux (102.60?±?1.12?µg/cm²/h) and permeability coefficient (32.78?±?1.38?cm/h). Significant effect of PE on lipid and protein framework of the skin was also observed which is responsible for increased permeation. The optimized formulation was found to be stable and showed no-sign of localized reactions, indicating safety and compatibility with the skin.

Conclusion: Thus, results indicated that the prepared intercalated transdermal matrix can be a promising nonoral carrier to deliver effective amounts of drug.     

White graphene based composite proton exchange membrane: Improved durability and proton conductivity

Boron nitride, which is also known as “white graphene” may be an attractive filler for composite proton exchange membrane. Application of polymer electrolyte membranes in fuel cell as an electrolyte is gaining attention due to the requirement of clean energy. However, despite its attractive features it requires more consideration for complete commercialization. Herein we demonstrate the preparation of novel functionalized WHITE GRAPHENE (hexagonal boron nitride) and sulfonated poly ether sulfone (SPES) based polymer electrolyte membranes (PEM). Composite membranes have been characterized through thermal, mechanical, structural analysis. Membranes have been subjected to measure methanol permeability and proton conductivity at different temperatures for its use in DMFC. Composite membranes exhibit good physicochemical properties as well as high methanol crossover resistance. 0.5 wt % of FBN (SP-FBN-05) membrane is found to be adequate to get the better performance in DMFC.     

Dietary and bioactive properties of the berries and leaves from the underutilized Hippophae salicifolia D. Don grown in Northeast India

Food Science and Biotechnology - The physico-chemical, polyphenols, antioxidant and antibacterial properties of berries and mixture of male and female leaves of Hippophae salicifolia were...     

Sediment Yield Assessment of a Large Basin using PSIAC Approach in GIS Environment

Reservoirs are the key infrastructure for the socio-economic development of a country. The reservoirs are proven to be a remedial solution of highly erratic spatial and temporal availability of water. The growth in population and consequent developmental activities within a catchment area has shown to aggravate the problem of sedimentation which comprised of erosion, sediment transport and its deposition in these reservoirs. Among all above mentioned, reservoir sediment deposition is most important as it reduces its useful life and impairs the purposes of these vast water resource. The sediment yield has been considered as comprehensive index for assessing sustainability of such resources. The present study investigates the suitability of Pacific Southwest Inter-Agency Committee (PSIAC) model in determining the sediment yield rate for a drainage basin considering nine basin factors in geographical information system (GIS) environment. For the analysis, a large river basin at the foothill of Himalayas in India has been considered as case study. It was realized that the GIS approach made large basin characteristic sampling very easy and efficient for this hilly basin. A regression equation between specific sediment yield and effective model factors was established based on geomorphic features for this basin. It was observed that most of the basin area is falling under moderate to high sediment yielding potential zone, leading to high sediment yield.     

An algebraic-Q4 turbulent eddy viscosity model: Boundary layer flow over a flat plate and flow in a pipe

An algebraic turbulent eddy viscosity model is proposed based on a length scale model coupled with the turbulent viscosity expression of the renormalization group theory of turbulence. The eddy viscosity is presented as a solution of a quartic equation. The new length scale model is based on boundary layer characteristics (displacement thickness, shape factor). The model is applied to transitional boundary layer flow over a flat plate and to flow in a smooth pipe. Predictions for the laminar-turbulent transition, and integral characteristics, such as the total skin friction coefficient, mean velocity profile across the boundary layer, and the friction coefficient in a pipe, are found to be in good agreement with experimental data.